ID   A0A315UWH6_GAMAF        Unreviewed;       621 AA.
AC   A0A315UWH6;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   28-JUN-2023, entry version 10.
DE   RecName: Full=FERM domain-containing protein {ECO:0000259|PROSITE:PS50057};
GN   ORFNames=CCH79_00008958 {ECO:0000313|EMBL:PWA15786.1};
OS   Gambusia affinis (Western mosquitofish) (Heterandria affinis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Gambusia.
OX   NCBI_TaxID=33528 {ECO:0000313|EMBL:PWA15786.1, ECO:0000313|Proteomes:UP000250572};
RN   [1] {ECO:0000313|EMBL:PWA15786.1, ECO:0000313|Proteomes:UP000250572}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NE01/NJP1002.9 {ECO:0000313|EMBL:PWA15786.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PWA15786.1};
RX   PubMed=29703783;
RA   Hoffberg S.L., Troendle N.J., Glenn T.C., Mahmud O., Louha S., Chalopin D.,
RA   Bennetzen J.L., Mauricio R.;
RT   "A High-Quality Reference Genome for the Invasive Mosquitofish Gambusia
RT   affinis Using a Chicago Library.";
RL   G3 (Bethesda) 8:1855-1861(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWA15786.1}.
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DR   EMBL; NHOQ01002573; PWA15786.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A315UWH6; -.
DR   STRING; 33528.ENSGAFP00000020344; -.
DR   Proteomes; UP000250572; Unassembled WGS sequence.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd17102; FERM_F1_FRMD3; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR000798; Ez/rad/moesin-like.
DR   InterPro; IPR014847; FA.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR019747; FERM_CS.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR018980; FERM_PH-like_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR   PANTHER; PTHR23280:SF8; FERM DOMAIN-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF08736; FA; 1.
DR   Pfam; PF09380; FERM_C; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   PRINTS; PR00935; BAND41.
DR   PRINTS; PR00661; ERMFAMILY.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM01195; FA; 1.
DR   SMART; SM01196; FERM_C; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS00660; FERM_1; 1.
DR   PROSITE; PS50057; FERM_3; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000250572};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        548..574
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          16..297
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
SQ   SEQUENCE   621 AA;  70510 MW;  1BA7CB34E55BA9A0 CRC64;
     MLRFRSPSIR SLDQEVLCTI RLLDDSEISC TIQKETKGQF LLDHVCNHYN LLEKDYFGIR
     YVDPEKQRHW LEPNKPVVKQ MKSALQPFTM CFRVKFYPHE PMKIKEELTR YLLYLQLKRD
     VYHGRLLCPF AEAAYLGACI IQAELGDYDP EEHPSDYIRD FKLFPKQSLK LERKIMEIHK
     NELRGQCAAL AELNMLQRAH SLETYGVDPH PCKDFTGSTA FLGFTATGFV VFQGNKRIHL
     LKWGDVSKLK FEGKTFYVIG VQKEKKLVLT FHTSTPAACK HLWKCGVENQ AFYKCAKSSQ
     IKTVSSSNIF FKGSRFRYSG KVAKEVIEAS SKIQRDPPEI HRAQFGQSRS FNSLSHKNLI
     MNMEPLVPAL PSTNEYEEAA ADPGVVAVKD PVPLSPLEPS AAADTEQSCA EKGSSSLIND
     LQPHCVSMET PYLPPLTPKA EDGLEEDDEG GGALTISELA YSPCASMLPT PVEDSQGGVN
     QLFSSPVQSP ARLLRELHAD PDIQAQLEAE RERDREFERT RLAARSRMSG VLASSLRLLS
     SNERVNTWVL GVARFVAVLM GVLFITVPTL LLLLESDIDV SFLHEIRQTP EFEQFHYEYY
     CPLRRWILCK ISMALENLWS D
//