ID A0A315V2C2_GAMAF Unreviewed; 2312 AA.
AC A0A315V2C2;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Centromere protein F {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=CCH79_00010547 {ECO:0000313|EMBL:PWA17279.1};
OS Gambusia affinis (Western mosquitofish) (Heterandria affinis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Gambusia.
OX NCBI_TaxID=33528 {ECO:0000313|EMBL:PWA17279.1, ECO:0000313|Proteomes:UP000250572};
RN [1] {ECO:0000313|EMBL:PWA17279.1, ECO:0000313|Proteomes:UP000250572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NE01/NJP1002.9 {ECO:0000313|EMBL:PWA17279.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PWA17279.1};
RX PubMed=29703783;
RA Hoffberg S.L., Troendle N.J., Glenn T.C., Mahmud O., Louha S., Chalopin D.,
RA Bennetzen J.L., Mauricio R.;
RT "A High-Quality Reference Genome for the Invasive Mosquitofish Gambusia
RT affinis Using a Chicago Library.";
RL G3 (Bethesda) 8:1855-1861(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA17279.1}.
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DR EMBL; NHOQ01002371; PWA17279.1; -; Genomic_DNA.
DR STRING; 33528.ENSGAFP00000008272; -.
DR Proteomes; UP000250572; Unassembled WGS sequence.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR Gene3D; 1.10.287.1490; -; 2.
DR Gene3D; 1.20.5.1000; arf6 gtpase in complex with a specific effector, jip4; 1.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874:SF10; CENTROMERE PROTEIN F; 1.
DR PANTHER; PTHR18874; CMF/LEK/CENP CELL DIVISION-RELATED; 1.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 1.
DR Pfam; PF10481; CENP-F_N; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000250572}.
FT DOMAIN 2..314
FT /note="Centromere protein Cenp-F N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1662..1801
FT /note="Centromere protein Cenp-F leucine-rich repeat-
FT containing"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2196..2240
FT /note="Kinetochore protein Cenp-F/LEK1 Rb protein-binding"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 133..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1415..1479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1512..1553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2018..2038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2103..2312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 21..125
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 179..206
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 851..888
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 924..1357
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1561..1637
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1666..1714
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1788..1829
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 138..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..609
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1448..1462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1512..1529
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1530..1546
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2119..2142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2143..2161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2164..2180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2285..2301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PWA17279.1"
SQ SEQUENCE 2312 AA; 263333 MW; 59324DAF7A9B551A CRC64;
AMSWAVEEWK DGLPGKALQK IQEMEVQLDK LKKERTQKQF QLESLEAALQ KQKQKVDSER
TEISALKREN QSMIESCDAL EKTRQKVVHD LGVKEQQVSY LEGQLNSCRK TIDRLEQELK
KWQTCRFSFR HKTELDRSQP AGSSSLSTSS SDLQTFSTPQ KTFATPAPVS ALRQPDSKLN
ELQEKYNHEV EERKKLESEL KLLQVKLLNQ SSVSHKDIAA RQAGSSIFPW QQQDQVHSLR
GQDVMETPLK RRGASSLWDA EETPIKPSQR MSSSRTVQSP SGSSQQTEQL KSLNQELRGR
VSELERNLAA QEKEIRTQTS KLQELQTHLN QTRKELSERD RELVKAGHEQ SQAADRYQQL
EAKCSMVEQK LKQVSEEMSC QRHNAESCRR ALEQKLKDQE RNSQKELAQL QSSHQALDQQ
LNQTRTKLTQ EVQQAKKDHN VLLADLEKMR LQKSQMEREI EELKQKLLRS EQGLQATQTK
EQDLRKKMEE LQKEKNALII QLDRSSRSLT QLEEEKRISE QSLKRSQGLL EDLKAKSEGQ
AEELKRLQSK LEHQTQTAAR ELEDVKKRLS DAEARNDKSQ NELQNQKQNE ELKSNLRQSR
DKSQAVKQEH QAVKQELQAV KQELQALLEW KKNKENLINQ TEAVQQELTD KIITLEGKAS
RLHEANNELQ DKISSMEADK ASLSAHVDAL KGELLLRSTE LEEKDHQNQQ LQLHVSEAAQ
KHGKDLENAG KQLAQLQGQV KDLESRLQRE ASRAQLAEKR SCELQEEQQA ACDLLRSKDQ
LLELGLAEVS QLKDGLARSA AQQEAQSDSF VKQKAVLLQQ CEESVSAQAE ETERVKLQAE
EILQFSHTER INALQEQIVC LEKQVSANQE ATEEVSVLKN KLDVVKQSLG HLNKSLEASE
KSLSCANETK ADLGVTLSEK VKLITALDDQ INNLIEKLKK ESESQSAEVG DFVNMERSLK
KHLEATKKSV AAAKAELSSR REEIRTMKTT LSAASRGLEE RDNTIKSLKE KLNKAEAEQA
KTSELLKEKT VAMNKIQVQL EMLQMDLEDN ESAMTSVEEL KGTIASLEAM LEESKAQVSV
LETRLDEVQS EYSLLETKYV TAKDELLERS CEITRLEEDA VRRQQLEENV SALEAKLSQI
TEENSKAETE LRQIIQEKES RLDQLNEEKN SLQASLTQSV DEQKRAESEI TRVKAEKAVL
EERMSNLSKE IQQLHAEVRE LSEQKQEAEA TIDQMAAETQ QTESALRRVS EKKAQLDVAL
SSASEEKVEL QEKISALTSE NGELVCKVKQ VEEEKLQLES KFSRFSEENV KLQSDMNRLT
AEKQQLQARA ERLQEEMASL REESQHVQHS LLSAEEEQQM YVPYLSMNQQ FEAEQTALHQ
KLSVLQTELA VLQQQYDVLQ QQVDQQQCII QQLTESQKHQ NPTGNIPHLE PRDAKDGEAA
GQTEPNPELG ASVGTSAESD PLNEQEEASE KSPDQAASEA ELIAQEDASD QEMINEEEAH
KHDAQEIQLH QQVSEENCSS NGDLENENCD ASSSQHEKRG MKFSGDESRP VNDVSVDTET
ISKQQNELKT LQSEFDLLTS ELQLRAELTS ELEVQVQRLE EKVQAVEKQL STALEEKKSL
SDQVTQLLEE RESLSLQLET SRCQLTDFME MLEGLEMAKG GWDEKFLQQE SELKRVRSEK
ANLEQHILGM ESELESMQAE TSRLKEELET QRKTCSGREQ QIETLLTETT QLRAELVSCS
EDRDELSQSL GQWRDKVHGL EKTNLETRNL ISILEEDIRV GRKEYQGLQS SMERVKAERE
QVVVLEEAIS KHNREKEGLL NHLHEMEDDH TSTNQNTESM AGKIQALEGE VCRLSQSLES
SLLEKGEIAS RLNSTQDEVR QMRTGIEKLQ VRIESDERKK KNMGELLKAA QRKSDSLQDR
IDALEREKDE FEQNLEEAVL QVSELTSSLA CLTKERDSAV SKMNLWMNTC KQLEQEKQNI
LNSSEGRSSE EFQAEATQLR AQAEVRKKEV QELKTALEKK TTEAEERRQE LRQKEEEVKE
RAAALEGVRA EKERELEKFR KELDEVNTLL EEKSTEADES MEKYCSLMVK VHKLEESNDA
LKTRLEQLTA SQPVNEAKLP PETRRRSARK SSSKHQEEKM SENTENLVPT TTPSSPQGWS
PGKRSHKEIS DRDSAQEALH NLTKKLKANT ATPRGRGGQD DEEFRPEGLP DLVQKGFADI
PLGEASPYII RRTTGRRCSP RLAARQSQPD VKVLGSVHLQ SPCGSSSDGS DRTRQPVRGE
QKPPLSVHQE AEQREKPVLM EQTKQGENCH VQ
//
