ID A0A315V3J7_GAMAF Unreviewed; 471 AA.
AC A0A315V3J7;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:PWA17903.1};
GN ORFNames=CCH79_00008089 {ECO:0000313|EMBL:PWA17903.1};
OS Gambusia affinis (Western mosquitofish) (Heterandria affinis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Gambusia.
OX NCBI_TaxID=33528 {ECO:0000313|EMBL:PWA17903.1, ECO:0000313|Proteomes:UP000250572};
RN [1] {ECO:0000313|EMBL:PWA17903.1, ECO:0000313|Proteomes:UP000250572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NE01/NJP1002.9 {ECO:0000313|EMBL:PWA17903.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PWA17903.1};
RX PubMed=29703783;
RA Hoffberg S.L., Troendle N.J., Glenn T.C., Mahmud O., Louha S., Chalopin D.,
RA Bennetzen J.L., Mauricio R.;
RT "A High-Quality Reference Genome for the Invasive Mosquitofish Gambusia
RT affinis Using a Chicago Library.";
RL G3 (Bethesda) 8:1855-1861(2018).
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}.
CC -!- SIMILARITY: Belongs to the claudin family.
CC {ECO:0000256|ARBA:ARBA00008295}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA17903.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NHOQ01002357; PWA17903.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A315V3J7; -.
DR STRING; 33528.ENSGAFP00000017035; -.
DR Proteomes; UP000250572; Unassembled WGS sequence.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; CLAUDIN; 1.
DR PANTHER; PTHR12002:SF32; CLAUDIN; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01077; CLAUDIN.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000250572};
KW Signal {ECO:0000256|SAM:SignalP};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..471
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016247586"
FT TRANSMEM 35..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 78..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 327..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 406..433
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 471 AA; 53602 MW; E9215CAB4B96C64C CRC64;
MTIISCMLSG LSLLILFCGA DFTTCVQNED AKPKISLVAA VGLMLAGLLV IIPVSWSAHN
TVRNFHNQLV HESQKRELGA SIYLGWAAGV LMLLAGGLLC CFSRPKSSSS GGTAKYSTSA
PNKNYVMGQV LGMNKYKRVK KVKKVDFMEE YVRQQFRGHD PPENNYGTLV ELNMRSIRQK
GEVDDKLLGK ESRSSSAVYF LKDFLIKHDL DFHVEPIVGP CTEREIERIK ARKVKLEMGE
RKEQIREKPV NPKALEKPPS AKSETCTLQK LLTDVKASLD ADEKDWTDFE QQMFKTMEEM
NKDLKKNFDM LTMINQAFES TDDIKKEVSG MKTPQDTKQP EPSPRKIPVT PPRVKMYCLS
PSVLQLTREM DEVDWVRKEA AVRFRKRNEF IDSTDEFLGI EEKCFYSREH EERKALQERL
KLEREAVERA KIQKLAHRQS TPDIMVPEGL RKSLSFENVA LKVGGDLAID D
//
