ID A0A315VT04_GAMAF Unreviewed; 1317 AA.
AC A0A315VT04;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=I/LWEQ domain-containing protein {ECO:0000259|PROSITE:PS50945};
GN ORFNames=CCH79_00001212 {ECO:0000313|EMBL:PWA26467.1};
OS Gambusia affinis (Western mosquitofish) (Heterandria affinis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Gambusia.
OX NCBI_TaxID=33528 {ECO:0000313|EMBL:PWA26467.1, ECO:0000313|Proteomes:UP000250572};
RN [1] {ECO:0000313|EMBL:PWA26467.1, ECO:0000313|Proteomes:UP000250572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NE01/NJP1002.9 {ECO:0000313|EMBL:PWA26467.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PWA26467.1};
RX PubMed=29703783;
RA Hoffberg S.L., Troendle N.J., Glenn T.C., Mahmud O., Louha S., Chalopin D.,
RA Bennetzen J.L., Mauricio R.;
RT "A High-Quality Reference Genome for the Invasive Mosquitofish Gambusia
RT affinis Using a Chicago Library.";
RL G3 (Bethesda) 8:1855-1861(2018).
CC -!- SIMILARITY: Belongs to the SLA2 family.
CC {ECO:0000256|ARBA:ARBA00010135}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA26467.1}.
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DR EMBL; NHOQ01001156; PWA26467.1; -; Genomic_DNA.
DR STRING; 33528.ENSGAFP00000006154; -.
DR Proteomes; UP000250572; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 6.10.250.920; -; 2.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 2.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR032422; HIP1_clath-bd.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR030224; Sla2_fam.
DR PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR10407:SF10; HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN; 1.
DR Pfam; PF07651; ANTH; 2.
DR Pfam; PF16515; HIP1_clath_bdg; 2.
DR Pfam; PF01608; I_LWEQ; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF109885; I/LWEQ domain; 2.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000250572}.
FT DOMAIN 960..1113
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT REGION 1135..1293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 461..495
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 569..628
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 668..765
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1151..1166
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1167..1288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1317 AA; 146253 MW; CCA6773C94C0080E CRC64;
MSKTKNKNDD KTEKALAAEK QQFGKQQLQS LSKIANTAEV PPKEKYVKAD RNNKKLNTLQ
QASRHVNDMA AVVVTSTKHG QQQISDHGVM DFSGMSLIKL KTEEMEAQGG ATTFWSYVPN
LPLSSQSLVS WKVCYLLHKV LREGHKNVSS SLHLLSVTSC LHPLRLTLFV SRPQPPTPDP
QVITDSHRHS RSIRDMGVLW GNLHDRYGHI VALSAKYLHL KMEFHAKHKV IPGNLEASDD
TLEREAGTDM TKVLDMTQEL LDHLDAGLKM AETVLRQMDA NGAKSTTPAG QCRLTPLVPL
ILDCSYLYHF SVRLLFKLHS RISADVLLGH RERFRDLFTS LTQFFNRARE IEFFKSIIQI
PELPDVSNLL ISSPQGPPNF LRAAALAEYK KPVVLMPGED RSEEDEVDTQ PELRETPQMS
QYYLVSQLGG PAEASLDYRD ADGNGYKREL EALKPEVELI KSEAQKCMIE LKSQVNRLEA
ELEEQRSHRQ VALVENEHLR MEVEALRSAN VANVGAQIGY KEADSRAQAA EVRFTQLKER
HAELVTSHAD LMKKNAETVK MLSGSKVAQD DLLRAKQQLE SEVENLRLEK RTATSHQQQE
VDRLTKELLE QRAEMAVLRS TLESKEKEGT QVSSSLTALQ AERDLLLRSA VEKDAELSSL
RQLAQQQQSS ADLEKERLSR ELEALRAQLQ QQLAINAEQR LEIDRLKREL DSTRAELTRA
NTLLQSKEMS GTQLSSTLAG LQAEKDALLR SVRDQEAELS SLRQQALLHH STLEQERQRS
SMELGSLRSQ MQQQACREGE LALKLRDEQF CLLQCAVVEA EGIILDAVAK LDDPIHVRCI
SSPDYLINRA EITLGSIDKM QQSHLLYLGN RNDVSGLLRA VTQFSHLAAD TIVNGSATSH
SAPVDHANSL TDSCRECASH CLQYLNDLKS QANLQRANPS AIRYTVQRIL AMGQELRPKG
QDVLKEELGS MVDKEMVATS TAIEEAVLRM DEILSQAKKG TNGLKLEVNQ SILGSCSDLM
KAVHILVTAA TDLQKDIVEG GRGAASVTEF YAKNSRWTEG LISASKAVGW GATQLLDSAD
RVVGEKGSYE ELIASSHEIA ASTAQLVAAS KVKVLQLENQ LDQERIRLGE LRKRHYELGG
PGSPDAKNDD NDSFPPPPPP TLLDPTSTPP SFSHTQPFTS TPSFSLPQSY TPSQTYTPSQ
PFTSSQPYTP SQAYTPPQIF TPSQTYAPSQ PYLPAQPYSS SMPYTPSPTQ SHLQPQSHLL
SQPSSLPSAA AQTKPPSQPQ SNTESHKVAF KKPNIFVKSG NLLKNAFKRG ETGTGES
//
