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Database: UniProt
Entry: A0A315W1X6_GAMAF
LinkDB: A0A315W1X6_GAMAF
Original site: A0A315W1X6_GAMAF 
ID   A0A315W1X6_GAMAF        Unreviewed;       952 AA.
AC   A0A315W1X6;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Sodium/potassium-transporting ATPase subunit alpha {ECO:0000256|RuleBase:RU362084};
DE   Flags: Fragment;
GN   ORFNames=CCH79_00009726 {ECO:0000313|EMBL:PWA29954.1};
OS   Gambusia affinis (Western mosquitofish) (Heterandria affinis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Gambusia.
OX   NCBI_TaxID=33528 {ECO:0000313|EMBL:PWA29954.1, ECO:0000313|Proteomes:UP000250572};
RN   [1] {ECO:0000313|EMBL:PWA29954.1, ECO:0000313|Proteomes:UP000250572}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NE01/NJP1002.9 {ECO:0000313|EMBL:PWA29954.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PWA29954.1};
RX   PubMed=29703783;
RA   Hoffberg S.L., Troendle N.J., Glenn T.C., Mahmud O., Louha S., Chalopin D.,
RA   Bennetzen J.L., Mauricio R.;
RT   "A High-Quality Reference Genome for the Invasive Mosquitofish Gambusia
RT   affinis Using a Chicago Library.";
RL   G3 (Bethesda) 8:1855-1861(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + K(+)(out) + Na(+)(in) = ADP + H(+) + K(+)(in) +
CC         Na(+)(out) + phosphate; Xref=Rhea:RHEA:18353, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29101, ChEBI:CHEBI:29103,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC         EC=7.2.2.13; Evidence={ECO:0000256|ARBA:ARBA00035887};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362084};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU362084}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC       family. Type IIC subfamily. {ECO:0000256|ARBA:ARBA00006934,
CC       ECO:0000256|RuleBase:RU362084}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU362084}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWA29954.1}.
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DR   EMBL; NHOQ01000466; PWA29954.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A315W1X6; -.
DR   STRING; 33528.ENSGAFP00000031175; -.
DR   Proteomes; UP000250572; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008556; F:P-type potassium transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd02608; P-type_ATPase_Na-K_like; 1.
DR   Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR   Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR   Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR   InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR005775; P-type_ATPase_IIC.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR   NCBIfam; TIGR01106; ATPase-IIC_X-K; 1.
DR   NCBIfam; TIGR01494; ATPase_P-type; 3.
DR   PANTHER; PTHR43294; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR43294:SF6; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-2; 1.
DR   Pfam; PF13246; Cation_ATPase; 1.
DR   Pfam; PF00689; Cation_ATPase_C; 1.
DR   Pfam; PF00690; Cation_ATPase_N; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   Pfam; PF00702; Hydrolase; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   PRINTS; PR00121; NAKATPASE.
DR   SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR   SFLD; SFLDF00027; p-type_atpase; 1.
DR   SMART; SM00831; Cation_ATPase_N; 1.
DR   SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR   SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362084};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU362084};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362084};
KW   Metal-binding {ECO:0000256|RuleBase:RU362084};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362084}; Potassium {ECO:0000256|RuleBase:RU362084};
KW   Potassium transport {ECO:0000256|RuleBase:RU362084};
KW   Reference proteome {ECO:0000313|Proteomes:UP000250572};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362084};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362084}; Transport {ECO:0000256|RuleBase:RU362084}.
FT   TRANSMEM        35..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        69..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        230..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        260..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        791..812
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        891..908
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   TRANSMEM        923..939
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362084"
FT   DOMAIN          1..55
FT                   /note="Cation-transporting P-type ATPase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00831"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:PWA29954.1"
FT   NON_TER         952
FT                   /evidence="ECO:0000313|EMBL:PWA29954.1"
SQ   SEQUENCE   952 AA;  104947 MW;  EC9EA71E6DCD5669 CRC64;
     GLTNARAAEV LARDGPNALT PPPTTPEWVK FCRQLFGGFS ILLWIGAVLC FLAYSIQMAM
     EDEPVNDNLY LGVVLAAVVI ITGCFSYFQE SKTSRIMDSF KKMVPQQAMV IREGEKLQIN
     AEFVVLGDLV EVKGGDRVPA DLRVISSSGC KVDNSSLTGE SEPQTRSPEL THENPLETRN
     ICFFSTNCVE GTACGIVIAT GDKTVMGRIA TLASELEVRQ TPISVEIEHF IHIITGVAVF
     LGMSFFILSL ILGYTWLEAV IFLIGIIVAN VPEGLLATVT VCLTLTAKRM AKKNCLVKNL
     EAVETLGSTS TICSDKTGTL TQNRMTVAHM WFDNQIHEAD TTEDQSGCGF DKNSGTWLCL
     SRVAGLCNRA VFKPGQENFP ILMRDTAGDA SESALLKCIE LYSGNVRDMR ARNPKVLEIP
     FNSTNKYQLS IHEVEDNPSG HLLVMKGAPE RILDRCSTIM MHGQEEVLDE NLRDAFQNAY
     LELGGLGERV LGFCHLNLSP SQFPRGFTFD CDITNFPTEQ LCFLGLISMI DPPRAAVPDA
     VGKCRSAGIK VIMVTGDHPI TAKAIAKGVG IISEGNETVE DIAERLNIPL SQVNPRDAKA
     CVVHGSDLKD MSAEYLDDLL RNHTEIVFAR TSPQQKLIIV EGCQRQGAIV AVTGDGVNDS
     PALKKADIGV AMGIAGSDVS KQAADMILLD DNFASIVTGV EEGRLIFDNL KKSIAYTLTS
     NIPEISPFLL FIIASVPLPL GTVTILCIDL GTDMVPAISL AYESAESDIM KRQPRNPKTD
     KLVNERLISM AYGQIGMMQA LAGFFTYFVI LAENGFLPRD LLGIRINWDD REFNDLEDSY
     GQQWTYEQRK IIEFTCHTAF FSSIVVVQWA DLIICKTRRN SLFQQGMRNR ILIFGLFVET
     ALAAFLSYCP GMDVALRMYP MKITWWFCAF PYSLLIFVYD EVRKLILRRS PG
//
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