ID A0A315W3X4_GAMAF Unreviewed; 1036 AA.
AC A0A315W3X4;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=PKD domain-containing protein {ECO:0000259|PROSITE:PS50093};
DE Flags: Fragment;
GN ORFNames=CCH79_00009138 {ECO:0000313|EMBL:PWA30690.1};
OS Gambusia affinis (Western mosquitofish) (Heterandria affinis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Gambusia.
OX NCBI_TaxID=33528 {ECO:0000313|EMBL:PWA30690.1, ECO:0000313|Proteomes:UP000250572};
RN [1] {ECO:0000313|EMBL:PWA30690.1, ECO:0000313|Proteomes:UP000250572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NE01/NJP1002.9 {ECO:0000313|EMBL:PWA30690.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PWA30690.1};
RX PubMed=29703783;
RA Hoffberg S.L., Troendle N.J., Glenn T.C., Mahmud O., Louha S., Chalopin D.,
RA Bennetzen J.L., Mauricio R.;
RT "A High-Quality Reference Genome for the Invasive Mosquitofish Gambusia
RT affinis Using a Chicago Library.";
RL G3 (Bethesda) 8:1855-1861(2018).
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA30690.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NHOQ01000347; PWA30690.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A315W3X4; -.
DR STRING; 33528.ENSGAFP00000023331; -.
DR Proteomes; UP000250572; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000250572};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 635..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 737..755
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 819..839
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 907..925
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 945..966
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 552..619
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT NON_TER 1036
FT /evidence="ECO:0000313|EMBL:PWA30690.1"
SQ SEQUENCE 1036 AA; 115575 MW; 2C6958EDC6C76467 CRC64;
MLLTDPEIES SLLISSDEGA TYQKYRLNFY ILSLLFHPEQ EDWILAYSHD QKLYSSVEFG
RRWQLVHEKV APNRFYWSKM GLDKEPGLIH LETSISEGQA LYVTCKLQNC TDANKGKPFP
GYIDPNSLVV QDEYVFVQVS TAGRPVYYVS AKRDVFTPMK LPKYTLPKEL HVISTDENRV
VAAVQEWNQN ETYNLYVSDT SGVFYTLALE NVVSSMGLEG NVMVDLYEVA GIKGMFLANK
KTENQVKTYI TYNRGRDWRL LQAPSRDLRG NSINCVLPYC SLHLHLHVSA NPYTSGNIAS
RESAPGIIVA SGSIGSELTT SNVSAFITSD AGNTWRQIFD EEYAVLYLDQ GGALVAIRHT
PLPIRHLWLS FDEGRQWNKY SFSNTPLFVD GVLGEPGEET LIMTIFGHFS HRSEWQLGEP
CLMGVKRIYR KLKPTSRCVM GKTYSVAMTL APCDCTEADF ECDYGYERRT DGKCSPAFWF
HPSSMSRSCT TGMTFLNSTG YRKVVSNNCT AGVIAEYTAR RQHCPIQAPK GLHLVTSEGR
LTATLGANVT FLVFLEEGDG ARTSVTVDFG DGHALTYSNV SSIEDGIKHI YKSVGIYRVT
ATGENSLGSE TATLFLHVTC EFLLKNNNNN TKTSAFIHGG LSSIFLIFLF FPLFITLCGI
AAVTSPRINT VTVQVSAGNA ILQDRKTIAV HEYFRSHLLS FSSNLDEHNP DVAEWRQDVS
RVIRNALIQA TGVREDLLLV TVLPGLPTAA EFFLLPDKQL TEGKAEKSSA HLDQLSDLLL
NALNQNLVQF TLRPGVQVTV YAAHLSAAPL VDTSENHSGS AMLMLLSVVV AGLAVFVIYK
FKRKIPGLNV YAQMQNDKEP EMMSPANPSE ATPSSPQDLV PSLEILDTEL NSRPIASRLV
SRLFRPILWL ILCFLSFLSE VVQTAGENFP HSSSELWTGL KPPAAILDLI LLLFGFCVWI
TMVWSFTPVH VGAGRHPALC WKQKKLCTGF IFFSFLLHVL KETCSDLSLF LSEEDRQHER
NEGLGFSHIL DRFAVF
//
