ID A0A315W543_GAMAF Unreviewed; 984 AA.
AC A0A315W543;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=General vesicular transport factor p115 {ECO:0000256|ARBA:ARBA00018243};
GN ORFNames=CCH79_00009176 {ECO:0000313|EMBL:PWA30717.1};
OS Gambusia affinis (Western mosquitofish) (Heterandria affinis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Gambusia.
OX NCBI_TaxID=33528 {ECO:0000313|EMBL:PWA30717.1, ECO:0000313|Proteomes:UP000250572};
RN [1] {ECO:0000313|EMBL:PWA30717.1, ECO:0000313|Proteomes:UP000250572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NE01/NJP1002.9 {ECO:0000313|EMBL:PWA30717.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PWA30717.1};
RX PubMed=29703783;
RA Hoffberg S.L., Troendle N.J., Glenn T.C., Mahmud O., Louha S., Chalopin D.,
RA Bennetzen J.L., Mauricio R.;
RT "A High-Quality Reference Genome for the Invasive Mosquitofish Gambusia
RT affinis Using a Chicago Library.";
RL G3 (Bethesda) 8:1855-1861(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the VDP/USO1/EDE1 family.
CC {ECO:0000256|ARBA:ARBA00006960}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA30717.1}.
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DR EMBL; NHOQ01000347; PWA30717.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A315W543; -.
DR STRING; 33528.ENSGAFP00000024544; -.
DR Proteomes; UP000250572; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0048280; P:vesicle fusion with Golgi apparatus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR041209; P115_Arm_rpt.
DR InterPro; IPR006955; Uso1_p115_C.
DR InterPro; IPR006953; Vesicle_Uso1_P115_head.
DR PANTHER; PTHR10013; GENERAL VESICULAR TRANSPORT FACTOR P115; 1.
DR PANTHER; PTHR10013:SF0; GENERAL VESICULAR TRANSPORT FACTOR P115; 1.
DR Pfam; PF18770; Arm_vescicular; 1.
DR Pfam; PF04871; Uso1_p115_C; 1.
DR Pfam; PF04869; Uso1_p115_head; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Reference proteome {ECO:0000313|Proteomes:UP000250572};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 60..97
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT DOMAIN 346..643
FT /note="Vesicle tethering protein Uso1/P115-like head"
FT /evidence="ECO:0000259|Pfam:PF04869"
FT DOMAIN 864..981
FT /note="Uso1/p115-like vesicle tethering protein C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04871"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 803..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..984
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 984 AA; 110248 MW; 226ACA9BFE20D951 CRC64;
MNFFRGVMGG QTAGPQPSGA ETIQKLCDRV ASSTLLEDRR DAVRALKSLS KKYRMEVGTQ
AMDHLINILQ TDRSDSEILG YALDTLYNLI SNDEEEEQDE TAQKQADDLG TQFTEKFIQD
PEHITLLLTL LEEFDFHVRW PGVKLLTALL KNQGVQVQGI ILVSPMGVSR LMDLLADSRE
VIRNDGLLLL QQLTKGNAAI QKIVAFENAF ERLLDIITEE GSSDGGIVVE DCLLLLLNLL
KNNSSNQNFF KEGSYIQRMK PWFEVGDDNS GWSAQKVTNL HLMLQLVRVM VSPVNSPGAT
ASCQKCMYQC GLLQQLCTIL MATGVPADIL TETINTVSEV IRGSQVNQDY FASVNAPSNP
PRPAIVVLLM SMVNERQPFV LRCAVLYCFQ CFLYKHQKGQ GEIVATLLPS TIDANSISAG
QLLCGGLFSA DSLSNWCAAV ALAHTLQDNL TQKEQLLRVQ LATSLGKPPV SLLQQCTNIL
SQVENASCLR LFQAGCFWGD KIVRRGSKVQ TRVGLLMLLC TWISNCPIAV THFLHNQDNV
PFLTAQISEN LGEDERLVQG LCALLLGICI YYNDNSLETY TKEKLKQLIE KRIGKENFVE
KLGFITNHEL YSRAALKPQP VFPSPEQMLF DHEFTRLVKE LEGPSSRQID SCGRFLFNQT
WKRCSVLFLL HTGLITKAVH KSSEEEKKEE EVKKTLEQHD NIVTQYKELI REQDAQIQEL
KEKVSSMTTQ TEQLQATVSQ QQSQIQQHKD QYNILKLKLG KDNQSQSSQG DTQVNGLQTE
ELAQLREELE ELRRQQKLLQ TQLSEKDAQI DSLKSATQTA EAPAGSDNTE ILQELEALKN
QVQTHLAEIS HLKAERQELL RRAEAGDSSS DAAKAELENR LAAQTAELER LKESRSGLEQ
QLAAATSTAA ILQTEKSKLQ TEVQESKKEQ DDLLMLLADQ DQKIHSLKQR LKDLGETTVA
LPLQVEDEDD LRDQTSDEDD EDED
//
