ID A0A315WMR7_GAMAF Unreviewed; 892 AA.
AC A0A315WMR7;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 22-FEB-2023, entry version 16.
DE RecName: Full=Gap junction protein {ECO:0000256|RuleBase:RU000630};
GN ORFNames=CCH79_00002679 {ECO:0000313|EMBL:PWA31499.1};
OS Gambusia affinis (Western mosquitofish) (Heterandria affinis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Gambusia.
OX NCBI_TaxID=33528 {ECO:0000313|EMBL:PWA31499.1, ECO:0000313|Proteomes:UP000250572};
RN [1] {ECO:0000313|EMBL:PWA31499.1, ECO:0000313|Proteomes:UP000250572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NE01/NJP1002.9 {ECO:0000313|EMBL:PWA31499.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PWA31499.1};
RX PubMed=29703783;
RA Hoffberg S.L., Troendle N.J., Glenn T.C., Mahmud O., Louha S., Chalopin D.,
RA Bennetzen J.L., Mauricio R.;
RT "A High-Quality Reference Genome for the Invasive Mosquitofish Gambusia
RT affinis Using a Chicago Library.";
RL G3 (Bethesda) 8:1855-1861(2018).
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell.
CC {ECO:0000256|RuleBase:RU000630}.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC {ECO:0000256|RuleBase:RU000630}.
CC -!- SUBCELLULAR LOCATION: Cell junction, gap junction
CC {ECO:0000256|ARBA:ARBA00004610}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU000630}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the connexin family. Alpha-type (group II)
CC subfamily. {ECO:0000256|ARBA:ARBA00006589}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA31499.1}.
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DR EMBL; NHOQ01000293; PWA31499.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A315WMR7; -.
DR STRING; 33528.ENSGAFP00000031649; -.
DR Proteomes; UP000250572; Unassembled WGS sequence.
DR GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 1.20.1440.80; Gap junction channel protein cysteine-rich domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013270; CD47_Vset.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR002266; Connexin50.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR PANTHER; PTHR11984; CONNEXIN; 1.
DR PANTHER; PTHR11984:SF19; GAP JUNCTION ALPHA-8 PROTEIN; 1.
DR Pfam; PF00029; Connexin; 1.
DR Pfam; PF03509; Connexin50; 1.
DR Pfam; PF08204; V-set_CD47; 1.
DR PRINTS; PR00206; CONNEXIN.
DR PRINTS; PR01137; CONNEXINA8.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868,
KW ECO:0000256|RuleBase:RU000630};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000250572};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000630};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 60..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 824..848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 455..565
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 627..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..657
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 892 AA; 100805 MW; 563A239C4001F15F CRC64;
MKSLCSSPQE DSAAVPSTRM RKMNKMISDD KCYGPTMGDW SFLGNILEEV NEHSTVIGRV
WLTVLFIFRI LILGTAAEFV WGDEQSDYVC NTQQPGCENV CYDEAFPISH IRLWVLQIIF
VSTPSLVYVG HAVHHVHMEE KRKEREEAEL SRQQELSEER LPLAPDQGSV RTTKETSTKG
SKKFRLEGTL LRTYICHIIF KTLFEVGFVV GQYFLYGFRI LPLYKCSRWP CPNTVDCFVS
RPTEKTVFII FMLAVACVSL FLNFVEISHL GLKKIRFVFR KPAPAPAQGE GTAPPLPSQG
KGLSPLAVPA LQRAKGYKLL EEEKVPPVTH LYPLAEVGME AGRGTPPFQT LEEKVEEVLP
MEDISKVYDE TLPSYSQTTG TGEVTLHEEE VEEVPPPEVE AERIEEGLDE DAEVEEAENE
EMETPAEAEV EATDTIEDTR PLSRLSKASS RARMPAKRKK EIKVNFVRYS HEEAKTITQV
AGSRVTLNCI DSDINITMGT WKFNEKDLFA FKSSKNKLRH NESVRLKVEM SDLESERYAL
IIGEAQKLHE GNYTCQITAN SGVFDEFWEL KITGGDKHPK VEAEASRFQR AGLRETPKGF
RMKCRALAYG TDPVRCAATD WRPVQGEPRL LPGTQLEIDT SDPPEPIRDK EFVAPGKKDR
NQSNSLSFNR KDSCVLPPRR APGVPIGRSG ERGGGDGLTG RNSSALLKFL RTADLQLDSI
RIKYSDQHRF FFLSVLFDRN GRRTKIFLKF FLALENRVVG REEGEYACGE VSLYSFCWPW
LSVKQRAVST FVELHKRNKF TDECKWQLVT PCCNNVRRLA QRLAWLPSLL TFLCFFCLLP
AGLLNAALCL SLLDPCLCPV RYGTEETEHE AGCTECSKWG GIRKASILQR IA
//
