ID A0A316CA90_PSESE Unreviewed; 690 AA.
AC A0A316CA90;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Short chain enoyl-CoA hydratase /3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:PWJ85996.1};
GN ORFNames=C7441_102447 {ECO:0000313|EMBL:PWJ85996.1};
OS Pseudaminobacter salicylatoxidans.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Phyllobacteriaceae; Pseudaminobacter.
OX NCBI_TaxID=93369 {ECO:0000313|EMBL:PWJ85996.1, ECO:0000313|Proteomes:UP000245396};
RN [1] {ECO:0000313|EMBL:PWJ85996.1, ECO:0000313|Proteomes:UP000245396}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6986 {ECO:0000313|EMBL:PWJ85996.1,
RC ECO:0000313|Proteomes:UP000245396};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|RuleBase:RU003707}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA
CC hydratase/isomerase family. {ECO:0000256|ARBA:ARBA00008750}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWJ85996.1}.
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DR EMBL; QGGG01000002; PWJ85996.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A316CA90; -.
DR STRING; 1192868.GCA_000304395_04193; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000245396; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000245396}.
FT DOMAIN 297..473
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 477..563
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 599..688
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 690 AA; 73121 MW; A7A7638FD33D458B CRC64;
MTEAVTIARD GEIAIVTIDN PPVNAMSFHV REPLMAALTA LRDDASVAGI VLACAGRTFV
AGADITEFGK PMQKPELRDL IAALETLGKP AVAAIHGTAL GGGLELALGC HFRVAEASAK
LGLPEVKLGI LPGGGGTVRL PRLVGPLKAL DMIVSGTPIS AKDALANGLV DALVDGDLVA
KAAAFAREQV KSGKQPVAVR DRNELVESAD LAAVDARATE LARKARGLEA PIACAEAVRN
ALTLPFDEAL TREREVFAKL VAGDQSKAQR HLFFAEREAA KVPGVGKDVK PREIARVGII
GAGTMGGGIA MAFVNGGIPV TLLEMNREAL DRGLATIEKN YAISVSRGSL TEEAKAGRMA
AFTPSTDYAD LADCDLIIEA VFEEMSVKKD VFGKIEAVAK PGAILATNTS YLDVNEIAAS
TGRPQDFLGL HFFSPANVMK LLEIVRGAKT APDVLATALA VGKKIGKVPV VVGVCHGFVG
NRMLGARGAE TEPLLLEGAT PQQVDNVFTD FGWPMGPFQM WDLAGLDIGW RNRKAQGKTA
VIADTLCERG HFGQKTGRGV YLYESGSRTP TPDPEVAALI EEKAKQLGID RREISSQEII
ERTFYPLINE GAKILEEGIA ARASDIDIVW VNGYGFPIGK GGPMFWASLE GYGKIVERLD
YWYARTGKDI FKPAELLRKA AETGKLAEAA
//
