ID   A0A316F5B3_9BURK        Unreviewed;       393 AA.
AC   A0A316F5B3;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=Acetyl-CoA C-acetyltransferase {ECO:0000313|EMBL:PWK38813.1};
GN   ORFNames=C7419_1012715 {ECO:0000313|EMBL:PWK38813.1};
OS   Cupriavidus plantarum.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=942865 {ECO:0000313|EMBL:PWK38813.1, ECO:0000313|Proteomes:UP000245754};
RN   [1] {ECO:0000313|EMBL:PWK38813.1, ECO:0000313|Proteomes:UP000245754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SLV-132 {ECO:0000313|EMBL:PWK38813.1,
RC   ECO:0000313|Proteomes:UP000245754};
RA   Whitman W.;
RT   "Genomic Encyclopedia of Type Strains, Phase IV (KMG-V): Genome sequencing
RT   to study the core and pangenomes of soil and plant-associated
RT   prokaryotes.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWK38813.1}.
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DR   EMBL; QGGT01000001; PWK38813.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A316F5B3; -.
DR   Proteomes; UP000245754; Unassembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020616; Thiolase_N.
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR   PANTHER; PTHR18919:SF138; ACETYL-COA C-ACETYLTRANSFERASE; 1.
DR   PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245754};
KW   Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:PWK38813.1}.
FT   DOMAIN          5..263
FT                   /note="Thiolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00108"
FT   DOMAIN          271..391
FT                   /note="Thiolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02803"
FT   ACT_SITE        89
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        349
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        379
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ   SEQUENCE   393 AA;  40747 MW;  2E59956FE76B6C0A CRC64;
     MLDPIVIVSA ARTPMGAFQG ELSALTAPQL GAAAIRAAVE RAGLKPEQVE EVVFGCVLPA
     GQGQAPARQA ALGAGLPLGV ACTTVNKMCG SGMRAAMTVF DGLLAGSFDI AVAGGMESMT
     NAPYLIPKGR GGYRIGHGMI YDHMMLDGLE DAYDKGRAMG TFGEDCAAKY AFTRAAQDQF
     AIESVQRAQQ AAANGDFQWE IAPVTVPAKG GDVTIDSDEG PRRIKTEKIP SLKPAFAKDG
     TITAASSSSI NDGAAALVMM RESTAKSLGL QPIARMLGHT SHAQAPGWFT TAPVEAIAKL
     YRKLDWTTDS VDLFEINEAF AVVPMAAMHE HRIPRAKVNI HGGACALGHP IGASGARILT
     TLIGALRKTG GKRGVATLCI GGGEATAVGI EMV
//