ID A0A316TJF7_9ACTN Unreviewed; 430 AA.
AC A0A316TJF7;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=Acetyl-CoA C-acetyltransferase {ECO:0000313|EMBL:PWN03681.1};
GN ORFNames=DJ010_06230 {ECO:0000313|EMBL:PWN03681.1};
OS Nocardioides silvaticus.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=2201891 {ECO:0000313|EMBL:PWN03681.1, ECO:0000313|Proteomes:UP000245507};
RN [1] {ECO:0000313|EMBL:PWN03681.1, ECO:0000313|Proteomes:UP000245507}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCTCC AB 2018079 {ECO:0000313|EMBL:PWN03681.1,
RC ECO:0000313|Proteomes:UP000245507};
RA Li C., Wang G.;
RT "Nocardioides silvaticus genome.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWN03681.1}.
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DR EMBL; QGDD01000002; PWN03681.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A316TJF7; -.
DR OrthoDB; 4440515at2; -.
DR Proteomes; UP000245507; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR42689; ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED; 1.
DR PANTHER; PTHR42689:SF1; ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000245507};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:PWN03681.1}.
FT DOMAIN 13..279
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 288..430
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 96
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 387
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 417
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 430 AA; 45346 MW; 612B43D2AA476772 CRC64;
MADSARSSVR RAAVIGGNRI PFARSNGAYA TASNQEMLTA TLDGLAARFG LEGERIGEVA
GGAVLKHSRD FNLVRESVLG SKLAPETAAV DLQQACGTGL QAINYVANKI KLGQLESGIG
GGVDTTSDAP IAISEKLRKK LIQLNNARST KDRLAVLASI RPGDIGLAIP SNGEPRTRLS
MGDHQALTAL EWQITREAQD ELAVTSHHNL ARSYDEGWQD DLVTPFRGLE RDNNLRADSS
LEKLAKLKPV FGKGEAATMT AGNSTPLTDG ASAVLLASDE WADEHGLTPL AYFVDSEVAA
VDFVNGHEGL LMAPAYAVPR LLARHGLTLQ DFDYYEIHEA FASQVLSTLA AWESPVFCKE
RLGLDAPLGS IDRSKLNVKG SSLAAGHPFA ATGGRIVANT AKLLAAKGSG RALISVCAAG
GQGVVAIMER
//
