ID A0A316TP28_9ACTN Unreviewed; 709 AA.
AC A0A316TP28;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:PWN04969.1};
GN Name=mrdA {ECO:0000313|EMBL:PWN04969.1};
GN ORFNames=DJ010_01975 {ECO:0000313|EMBL:PWN04969.1};
OS Nocardioides silvaticus.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=2201891 {ECO:0000313|EMBL:PWN04969.1, ECO:0000313|Proteomes:UP000245507};
RN [1] {ECO:0000313|EMBL:PWN04969.1, ECO:0000313|Proteomes:UP000245507}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCTCC AB 2018079 {ECO:0000313|EMBL:PWN04969.1,
RC ECO:0000313|Proteomes:UP000245507};
RA Li C., Wang G.;
RT "Nocardioides silvaticus genome.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWN04969.1}.
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DR EMBL; QGDD01000001; PWN04969.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A316TP28; -.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000245507; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000245507}.
FT DOMAIN 59..249
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 301..656
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 678..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 709 AA; 77344 MW; 1099B8AE95D08916 CRC64;
MTPTTATSSH RSRLRLIVIQ ALVFSLLATL GARLYYLQVV TGEEYQGKAA SQSVRDIVVQ
PQRGLIVDAE GRPLVTNRLT WVASVDRTLI GRMEPRLRKR LLERVGRVIG VEPREIARKL
VLCGTEGAKE GVCWNGSPYQ PVPVAQDLDD VTALRINEQP EDFPGVVVAQ QTVRDYPQPY
GINAAHLLGY LSPITEDELT AAEVGGDTSV NGASVVGRAG VEKEYDAWLR GQPGYERVKV
NANGEVIGEE GDVRSQPGDT LVTSIDAKVQ SIVERQLHRM IMTQRATVDP VTGRRFEADS
GAAVVMDVHT GRIVAMASQP TYDPEIWAGG ITQKQLKHLY SEAAGTPLLG RALQGQFAPG
STWKPFMTAG ALTHGYGPDT RLDCSSAFRV GNRDFKNYES GAYGYISFAD ALRVSCNTFF
YRIGYDYWQR FGSDVADVDA KDPLVEQALD FGFGKPTGID IPGESSGRIA DRKWKRSYYK
QMKDYYCGIA DKPQDAKTSD FVYKFAYEFC VEGYAYRAGD AVNFAIGQGD TIVTPLQLAR
AYAALANGGT LWEPRVGKAI VSPDGSVIRK IPPSKQGEVD VPKAVLDYID EALKEVPRTG
TLAWKLGGFP LDDVVLRAKT GSAEVYGKQS TGWVASYSDD YVVVMMISQG GTGSGSTGDG
IRKIWEALYG VDGETVRPDR SAIEGTTPPE RLPVFGRDGS ILPPTREED
//
