ID A0A316ZGC3_9BASI Unreviewed; 550 AA.
AC A0A316ZGC3;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=FA09DRAFT_333184 {ECO:0000313|EMBL:PWO00801.1};
OS Tilletiopsis washingtonensis.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Exobasidiomycetes; Entylomatales; Entylomatales incertae sedis;
OC Tilletiopsis.
OX NCBI_TaxID=58919 {ECO:0000313|EMBL:PWO00801.1, ECO:0000313|Proteomes:UP000245946};
RN [1] {ECO:0000313|EMBL:PWO00801.1, ECO:0000313|Proteomes:UP000245946}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MCA 4186 {ECO:0000313|EMBL:PWO00801.1,
RC ECO:0000313|Proteomes:UP000245946};
RX PubMed=29771364; DOI=10.1093/molbev/msy072;
RA Kijpornyongpan T., Mondo S.J., Barry K., Sandor L., Lee J., Lipzen A.,
RA Pangilinan J., LaButti K., Hainaut M., Henrissat B., Grigoriev I.V.,
RA Spatafora J.W., Aime M.C.;
RT "Broad genomic sampling reveals a smut pathogenic ancestry of the fungal
RT clade Ustilaginomycotina.";
RL Mol. Biol. Evol. 0:0-0(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; KZ819284; PWO00801.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A316ZGC3; -.
DR STRING; 58919.A0A316ZGC3; -.
DR OrthoDB; 3639304at2759; -.
DR Proteomes; UP000245946; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000245946}.
FT DOMAIN 57..436
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 550 AA; 58006 MW; 72AEDDF4256ED70E CRC64;
MQAFGRPGGP RRDASSSSSA PSQAGVAVAR EAATASTTGG GEDGSEPKVK QLAAGPVRTI
LLNRPKALNA LDMDMILLIA DALQTFSKTP APVVLLRGVG RALCSGGDVM AVVKQAADED
PAVRQQALTF FKAEFELDYA IATLFRRTGK TFVSVMDGIT MGGGVGLSVH APIRIATEKT
LFAMPETGIG YWPDVGVTRQ LARLDGKVGF YLGITGARIS GEEAYIAGLA THYIPSSLLA
EALERLGSLG PDAKSDSVSN VLDEFSADPF SETEVAKGPQ ILAQSALLGS RRVALDHVFG
QKSAEGIFAA LEQLAAGAAD SEAAAELRTR GAELDEGVVS WARTTLDALL TKSPRSIKVS
LRAIAAARQL EDAEAFRLDM RLATAFCDLG AGRDFHTGVM HTLARDPETG KRRTGVAPWD
VRSVADVSDQ HISDLFFGDQ QAARSAGMTM DVPRLAGLPP PNALSADEQR AQRNKTKGLP
PLGWQVGHNM FALPAEAEIA ALVSGYHPSS PPTQLEPEEV VAVLRSVKGD RRGLDGKVRE
FLQRSGAAFA
//
