ID A0A317FIR3_9PROT Unreviewed; 2048 AA.
AC A0A317FIR3;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=VWFA domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DFH01_06995 {ECO:0000313|EMBL:PWS38984.1};
OS Falsiroseomonas bella.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Acetobacteraceae; Falsiroseomonas.
OX NCBI_TaxID=2184016 {ECO:0000313|EMBL:PWS38984.1, ECO:0000313|Proteomes:UP000245765};
RN [1] {ECO:0000313|Proteomes:UP000245765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CQN31 {ECO:0000313|Proteomes:UP000245765};
RA Du Z., Wang X.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWS38984.1}.
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DR EMBL; QGNA01000001; PWS38984.1; -; Genomic_DNA.
DR OrthoDB; 7270858at2; -.
DR Proteomes; UP000245765; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd11304; Cadherin_repeat; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 3.
DR Gene3D; 2.150.10.10; Serralysin-like metalloprotease, C-terminal; 8.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR018511; Hemolysin-typ_Ca-bd_CS.
DR InterPro; IPR001343; Hemolysn_Ca-bd.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR011049; Serralysin-like_metalloprot_C.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR38340; S-LAYER PROTEIN; 1.
DR PANTHER; PTHR38340:SF1; S-LAYER PROTEIN; 1.
DR Pfam; PF01839; FG-GAP; 6.
DR Pfam; PF00353; HemolysinCabind; 13.
DR Pfam; PF00362; Integrin_beta; 1.
DR PRINTS; PR00313; CABNDNGRPT.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM00191; Int_alpha; 7.
DR SUPFAM; SSF51120; beta-Roll; 9.
DR SUPFAM; SSF49313; Cadherin-like; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 2.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50268; CADHERIN_2; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00330; HEMOLYSIN_CALCIUM; 9.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000245765};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1152..1366
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1507..1621
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 616..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2048 AA; 200502 MW; 341386CA8C90C6D4 CRC64;
MPLPVTKVFL VGATAGSGGY VLTPEETGDM AYVATGFPSA SWVTTIGDID GDGIAEIVAG
VPGNGDQEIG GGRVYIEMGG AAGGSSFKLG DNLTSIRLDG AFPDDHVGSA VAATGDMNGN
GLQELLVGAP EADRNGETDS GVAYLFFTPT APGSTDLKDL DDAGSNEGFA MFGEAGGDMA
GYAVAGIADL NGDGRADLVV GAPGSDAGGT DGGAAYVVWG KATRAGVELA NVAAGTGGYR
ITGVAGEAAG SALATLGDLN GDGKAEILVG APGADGGAGA AYVVFGKGTT AEVDLADVAA
GTGGFRITGA NPGEAAGMRL AALGDVNGDG LADMLLGSTG LAYVVFGKAD TAEVSLADVA
NGLGGFAILP ESWGDLDDIA VAGGGDLNRD GVNDIVIGAS HNGEGGFDAG AVYVVWGGGS
GTVDLAMIAE GAGGAKVVGS AGSYTGSSVA VAPDLDGDGA ADLVIGSPGA ALEQVSILYA
PDSWQPDDNV YGTNGDDLLG AGSGSRHLVG EGDDSIYAFA GADSISAGGG HDLLDGGADA
DTMRGGAGDD VYVVDVAEDV VLEEAGGGAD TVDATVSYIL GDGVEALRLT VAGLAGTGNA
GDNLLFGSTG DDTLEGAEGA DTLAGDAGND SLDGGAGADS MAGGTGNDAY AVDDAGDVIE
EAPGAGADTM VASIETALGT NLEVLVLAGA AHAGSGNDGA NTLVGGAGDD SLSGLGGGDS
LVGDGGDDRL DGGTGADSMA GGAGNDLYIV DNLLDRAIEA AGGGADTVVS AVDFTLGTEV
EALVLTEPGH KGMGNALGNA ITGTSGADTL DGAGGADTLA GGAGDDVYVV DSGADAIVED
AAGGHDLVRS AVTYVLGAEL EDLVLTTPGV SGTGNAGNNA LTGTAGGDTL DGAGGDDTMT
GGGGNDAYRV DGAGDMIVEA AGGGADTVFA SFDTTLAADV EVLALEGEAH HATGNEGDNR
LIGGVGEDSL EALGGADTLD GGAGADTMAG GLGDDTYVIS DPGDVVLELP GEGFDTVVVS
TDWVLADGIE GVQLVGSGHV LTGNAGANTL SGNSGDDTLD GASGDDILLG GDGNDVLVGD
DGLDTLSGGS GDDRFELHGS AAHVEDFLGE DTIDASDALG DSYIDLSGDT QTEIEDQLCD
FGQGGSTAGP LDLQFLQDLT GSFGDDIAMV RSLVPQIVLA LQTVQPNSTY GVSSFRDKAF
GGFGNVGDWV YRQETALAND TAALLASYTA MAAGGGADGS EAQIEALMQL ALHVTDVGFR
TNSARFVVLF TDASYHAAGD GLAAGIPLPN NGDGVLDGTP PGTGEDYPAI AQVKAALEAA
NIIPIFAVAG GFVGDYQNLV TQLGRGAAVT LSADSSNVVS AITTGLTAVT QTRIEDAWGG
EGADTLKGNS AANELRGAAG NDSLDGGEND DTLIGGDGAD TMAGGGGIDM ACFDLDWKEY
EIGRDSVSGA WSLTHAGLTA VVTSDVETLR FGAGPAALVV DLVAAADAVA SAAPVIATVT
EAGTDEDADP ATLQLAENLP AGTVVALLVA TDANLPMGDA LSAALVLGDG TPDLASPFEL
VAVAGGWELR STAPLDFETS PGFTLRLAVT DLAGHVATQD VTVGVLDVEE GIFGTADADS
LAGTALDDLM RGLGGGDTLV GQAGADTLDG GTGADRMAGG AGNDEYRVDD IADRVLETRT
GGADTVCSAL SWTLGAHQED LVLTGDAAID GTGNDLANVI TGNDAANVLT GAGRADTMAG
GGGDDLYLVD ATDLLVEQPG GGHDTVVANA TFALADNIED LRFNGSANVR GDGNAENNSI
RGNVGNNRLV GYDGDDTLFG SLGNDTLQGG EGADSLVGSE GVDRLDGGNG DDTYVIADAD
LVVELPNAGI DTVLSAISYV LPGAVENLSL LGTHDLSGIG NALANVLNGN SGANLLRGLG
EADRVSGGGG ADTMDGGLGA DTLTGGGGFD RFLWQDPGEG ADIVTDFRSG EDHVAFRTGG
FGGLAVGALD PAHFAKDAPG AALPQFVYEE TTGTLTWDAD GTDVGEAFTI AVFANLPILG
AADIQLIA
//
