ID A0A317K2T4_9ACTN Unreviewed; 790 AA.
AC A0A317K2T4;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Family 65 glycosyl hydrolase {ECO:0000313|EMBL:PWU47255.1};
GN ORFNames=DKL51_15470 {ECO:0000313|EMBL:RQW94896.1}, DLJ46_15300
GN {ECO:0000313|EMBL:PWU47255.1};
OS Micromonospora globispora.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=1450148 {ECO:0000313|EMBL:PWU47255.1, ECO:0000313|Proteomes:UP000245683};
RN [1] {ECO:0000313|EMBL:PWU47255.1, ECO:0000313|Proteomes:UP000280363}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S2901 {ECO:0000313|EMBL:RQW94896.1,
RC ECO:0000313|Proteomes:UP000280363}, and S2904
RC {ECO:0000313|EMBL:PWU47255.1};
RA Carro L., Veyisoglu A., Cetin D., Klenk H.-P., Trujillo M.E., Sahin N.;
RT "Micromonospora globispora sp. nov. and Micromonospora rugosa sp. nov.,
RT isolated from marine sediment.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000245683}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S2904 {ECO:0000313|Proteomes:UP000245683};
RA Carro L., Aysel V., Cetin D., Igual J.M., Klenk H.-P., Trujillo M.E.,
RA Sahin N.;
RT "Micromonospora globispora sp. nov. and Micromonospora rugosa sp. nov.,
RT isolated from marine sediment.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 65 family.
CC {ECO:0000256|ARBA:ARBA00006768}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWU47255.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; QGSV01000196; PWU47255.1; -; Genomic_DNA.
DR EMBL; QGGF01000313; RQW94896.1; -; Genomic_DNA.
DR OrthoDB; 9816160at2; -.
DR Proteomes; UP000245683; Unassembled WGS sequence.
DR Proteomes; UP000280363; Unassembled WGS sequence.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.70.98.40; Glycoside hydrolase, family 65, N-terminal domain; 1.
DR Gene3D; 2.60.420.10; Maltose phosphorylase, domain 3; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR005194; Glyco_hydro_65_C.
DR InterPro; IPR005195; Glyco_hydro_65_M.
DR InterPro; IPR005196; Glyco_hydro_65_N.
DR InterPro; IPR037018; Glyco_hydro_65_N_sf.
DR InterPro; IPR017045; Malt_Pase/Glycosyl_Hdrlase.
DR PANTHER; PTHR11051; GLYCOSYL HYDROLASE-RELATED; 1.
DR PANTHER; PTHR11051:SF13; GLYCOSYL TRANSFERASE-RELATED; 1.
DR Pfam; PF03633; Glyco_hydro_65C; 1.
DR Pfam; PF03632; Glyco_hydro_65m; 1.
DR Pfam; PF03636; Glyco_hydro_65N; 1.
DR PIRSF; PIRSF036289; Glycosyl_hydrolase_malt_phosph; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000313|EMBL:PWU47255.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245683}.
FT DOMAIN 16..270
FT /note="Glycoside hydrolase family 65 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03636"
FT DOMAIN 327..679
FT /note="Glycoside hydrolase family 65 central catalytic"
FT /evidence="ECO:0000259|Pfam:PF03632"
FT DOMAIN 689..753
FT /note="Glycoside hydrolase family 65 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03633"
FT REGION 759..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..780
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 488
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-50"
FT BINDING 361..362
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-51"
FT BINDING 592..593
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-51"
SQ SEQUENCE 790 AA; 88591 MW; 47F15EA5471A87C8 CRC64;
MIRERAYPVE PWHVRETRLD MDVLAQSESV FALSNGHVGL RGNLDEGEPH GLPGTYLNSF
YELRPLPYAE AGFGFPESGQ TIVNVTNGKL IRLLVDDEPL DVRYGELLFH ERILDLRAGT
LHREVHWRSP AGQQVKVRST RLVSFTQRSV AAIHYEVEAV DAPIRLILQS ELVANETLPA
QSRDPRVAAV LESPLQAEEE LTTDDGGLLI HSTKVSGLRV GAAMAHDVHG PERTTIESEG
YEDWVRTTVG CVLKPGQVLR VVKYLTYGWS SRRSLPALRD QVGAALAAAR LDGWDGLRRA
QREYLDEFWD AADVRVEGDP EVQQAVRFGL FHVLQAGARA ERRPISAKGL TGPGYDGHAF
WDTEMFVLPV LTYTQPSAAR DALYWRHSTL AQAHERARTL NLKGAAFPWR TIDGPESSAY
WPAGTAAFHI AADIADALRR YVLVTGDEAL EQEIGLELLV ETARLWRSLG HHDRNGQFHI
DGVTGPDEYT AVKNDNIYTN LMAQRNLLTA AECAMQYRDQ AADLGVSEEE AAAWRDAANA
MHIPYDEGLD VHEQVEGFPR LQEWDFEHTP PEKYPLLLHY PYFDLYRKQV VKQADLVLAM
HWRGDAFTGP QKLRNFQYYE RRTVRDSSLS ACTQAVMAAE VGFPELAHRY LREAALMDLH
DLNENTRDGV HMASLAGAWI ALVAGFGGLR DHDGTLSFSP RLSSRLSRLE FSLQWRSMHL
RVDVRPHQTT YQLRRGGPDT EVELRHHGEP IRVTCEQPVT VPVPPAHPSG PPPEQPPGRA
PLLHLPENSV
//
