ID A0A317SEH9_9PEZI Unreviewed; 1140 AA.
AC A0A317SEH9;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 08-NOV-2023, entry version 16.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=C7212DRAFT_285793 {ECO:0000313|EMBL:PWW72755.1};
OS Tuber magnatum (white Piedmont truffle).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Tuberaceae; Tuber.
OX NCBI_TaxID=42249 {ECO:0000313|EMBL:PWW72755.1, ECO:0000313|Proteomes:UP000246991};
RN [1] {ECO:0000313|EMBL:PWW72755.1, ECO:0000313|Proteomes:UP000246991}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=091103-1 {ECO:0000313|EMBL:PWW72755.1};
RA Murat C., Payen T., Noel B., Kuo A., Martin F.M.;
RT "Genomes of Pezizomycetes fungi and the evolution of truffles.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWW72755.1}.
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DR EMBL; PYWC01000094; PWW72755.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A317SEH9; -.
DR STRING; 42249.A0A317SEH9; -.
DR Proteomes; UP000246991; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR024729; USP7_ICP0-binding_dom.
DR InterPro; IPR029346; USP_C.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF644; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE K02C4.3-RELATED; 1.
DR Pfam; PF00917; MATH; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF14533; USP7_C2; 1.
DR Pfam; PF12436; USP7_ICP0_bdg; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000246991};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 73..201
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT DOMAIN 227..547
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
SQ SEQUENCE 1140 AA; 131526 MW; 9B0A88CA71DCA2D0 CRC64;
MGVIQEQPDD QAMVIDGLDQ DNGKTQDVTI ISPQQSIDSG SADDKDSIVL ADDHEAMKKI
LLPDIPDLET EDETTYTWKI ENWRKMERRS RGPVFHCGGA PWRVLFFPQG NNCDFTSFYL
EQGFDEKPPE NWYKCVQFGL VLWNPNDPSV HVTHQAHHRF TVDEGDWGFT KFYELRLLMS
PTKERARPLV EDESANLTAY VRVVKDPTGV LWHNFLNYDS KKETGYVGLK NQGATCYLNS
LLQSLYFTNS FRKAVYQIPT ENEPLSNSAL TLQRLFYLLQ TSNEAVGTYE LTRSFGWETQ
DIFAQQDVQE LNRILMESLE QKMKGTQAEN SLAKLFVGKT KTYIKCINVD YTSERIEDFW
DIQLNVRGFK NLDESFKDYI AVETMDGENK YFAEGHGLQD AKKGVIFESF PEVLHLHLKR
FEYDLNTYAM QKVNDHYEFP EEFDAAPYLS EDADQSEPYT YALHGVLVHS GDLNAGHYYA
FLRPEKDGRF LKFDDDRVTK ATLRETMDEN FGGDYGPATN GLPRNPQARA ISVKRSMNAY
MLVYLRKNKI DEILPAVTEE DTPPHLQKKL DEERATRELR KRERDEQHLY LNVKVITESQ
FKAHQGFDLT SWDDKDQPEE AQPRHYRVLK ASLVKDLVEK VAADICVDPC NVRLWIMVNR
QNKTVRPDQP LTIPEMSIED ASNKHNNKSS DFRLWAEVAT ENKPGKNLEP WAQARDSNSA
WIVVFLKRYD PGSQTLRGVG HLYMRKNDKV AELIPAILTE MNWPRDTPLK LYEEIKPQMI
EPMKPKQTFN QAEIQDGDII CFQKSYTEKE AQALFRESLI PDAKDFYDLL VNRIVIKFHP
KSSHIAEGKV FDLTLNKKMT YDQLAEKVGD FLDAPPTHLR FTTINAATGG ARSTIKRNPN
ATLHQMLTTT YYSNTTISPN SLYYEVLELS LTELETMKTL KLFWLPEGIV KEELVEILVP
KNGQVQDVAA ILQKKLELDD ETASKLRFYE SHLGRFYKEL EPAFNVAGIQ DYMNLLAERR
PNEELEMEEG DRFINAFHYH KEPSKAHAFG IPFRFVVKQG EIFEKTKERL QLRTGIKGKP
FEKIKFAVVR KSNVPKPIYL SDEDILADVA SETDDVLGLD HIDKNSRTWG RSGGPEIRIR
//