ID   A0A317SK25_9PEZI        Unreviewed;       975 AA.
AC   A0A317SK25;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=Pro-apoptotic serine protease NMA111 {ECO:0000256|ARBA:ARBA00020338};
DE   AltName: Full=Pro-apoptotic serine protease nma111 {ECO:0000256|ARBA:ARBA00021524};
GN   ORFNames=C7212DRAFT_353401 {ECO:0000313|EMBL:PWW74779.1};
OS   Tuber magnatum (white Piedmont truffle).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC   Pezizales; Tuberaceae; Tuber.
OX   NCBI_TaxID=42249 {ECO:0000313|EMBL:PWW74779.1, ECO:0000313|Proteomes:UP000246991};
RN   [1] {ECO:0000313|EMBL:PWW74779.1, ECO:0000313|Proteomes:UP000246991}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=091103-1 {ECO:0000313|EMBL:PWW74779.1};
RA   Murat C., Payen T., Noel B., Kuo A., Martin F.M.;
RT   "Genomes of Pezizomycetes fungi and the evolution of truffles.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000256|ARBA:ARBA00002558}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family.
CC       {ECO:0000256|ARBA:ARBA00010541}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWW74779.1}.
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DR   EMBL; PYWC01000057; PWW74779.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A317SK25; -.
DR   STRING; 42249.A0A317SK25; -.
DR   Proteomes; UP000246991; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00987; PDZ_serine_protease; 1.
DR   Gene3D; 2.30.42.10; -; 2.
DR   Gene3D; 2.40.10.120; -; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   PANTHER; PTHR46366; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR   PANTHER; PTHR46366:SF8; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR   Pfam; PF12812; PDZ_1; 2.
DR   Pfam; PF13365; Trypsin_2; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022825};
KW   Protease {ECO:0000313|EMBL:PWW74779.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000246991};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT   DOMAIN          276..348
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|SMART:SM00228"
FT   DOMAIN          840..921
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|SMART:SM00228"
SQ   SEQUENCE   975 AA;  108313 MW;  7F9E75ADC38B03FE CRC64;
     MEMNGDSRAK RNKDDIHLPG DAEQGFVALE TRLLPSAVAT HDSAEWQKTI EEVVRNVVSI
     RFCQTCSFDT ESAITSEATG FIVDAERGYI LTNRHVVCAG PFWGYCVFDN HEECDVYPVY
     RDPIHDFGIL RFDPKAIKYM PVGALQLRPD LARVGAEIRV VGNDAGEKLS ILSGVISRVD
     RNAPDYGDGY NDFNTNYIQA AASASGGSSG SPVVNIDGYA VALQAGGTAT DYFLPLDRPL
     RALECIRNGR PVTRGTIQTQ WLTKPFDECR RVGLSPEWEA AVRKGFPKEI GMLVAEVVLP
     EGPAHGHIEE GDILIKVNGA LITKFVDLDE ILDNSVGKGV KMLVERGGKA MDIELDVGDL
     HAITPDRFLT VCGASFHDLS YQSARLYAIP VRGVYVCEPA GSFRFDGMDK GWIIESLDNK
     KTPNLNEFIE VVKNIPDRSR VVATYRHLRD LHTMHTSILY IDRHWTAKMR MAIRNDVAGL
     WDFSDIAEPK PPVPLAPSSA QFIRLDNVGY PAASDLVRSF VRISCVMPIK LDGFPRARKT
     GFGLVVDAEK GLVVVSRAVV PYDLCDISIT VAESIVVEGK VLFLHPLQNY AVVQYDPTLV
     KAPVLSARLS SEHITQGASA MFLGFNQNLR VVVAKTSVTD ITTVAVPANS SAPRYRAINV
     DAITVDTSLS GQCGSGVLAD ADGTVQALWL TYLGERTHSN KDVEYHLGLA TPSLLPVIRQ
     LQNGIIPKLR MLNVELHLVH MSQVRIMGVS EEWIRRVEQD NPERHQLFMV RKVECGHSQT
     LEEGDVILSI NGKVMTRITE LDVMYDHEHL DMVVVRNCEE MTLRVPTVPT DDLETDRAVI
     FCGAVLHRPH HAVRQQISTI HSEIYVSART RGSPAYQYQL VPTNFIVGVN GVKTSDLDSF
     LHEVSKIPDN TYLRLRIITF DNIPFVITIK KNEHYFPTME FIKDPSEPCG WRRQTYEGKF
     THAGIKTHMD ELGGE
//