ID A0A317V9Y4_9EURO Unreviewed; 1417 AA.
AC A0A317V9Y4;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Pre-mRNA-splicing factor {ECO:0000256|PIRNR:PIRNR038901};
GN ORFNames=BO94DRAFT_291870 {ECO:0000313|EMBL:PWY69848.1};
OS Aspergillus sclerotioniger CBS 115572.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1450535 {ECO:0000313|EMBL:PWY69848.1, ECO:0000313|Proteomes:UP000246702};
RN [1] {ECO:0000313|EMBL:PWY69848.1, ECO:0000313|Proteomes:UP000246702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 115572 {ECO:0000313|EMBL:PWY69848.1,
RC ECO:0000313|Proteomes:UP000246702};
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De Vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in mRNA splicing where it associates with cdc5 and
CC the other cwf proteins as part of the spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBUNIT: Belongs to the 40S cdc5-associated complex (or cwf complex), a
CC spliceosome sub-complex reminiscent of a late-stage spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SIMILARITY: Belongs to the CWF11 family.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWY69848.1}.
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DR EMBL; MSFK01000040; PWY69848.1; -; Genomic_DNA.
DR STRING; 1450535.A0A317V9Y4; -.
DR OrthoDB; 7041at2759; -.
DR Proteomes; UP000246702; Unassembled WGS sequence.
DR GO; GO:0005684; C:U2-type spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd17935; EEXXQc_AQR; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR048966; Aquarius_b-barrel.
DR InterPro; IPR048967; Aquarius_insert.
DR InterPro; IPR032174; Aquarius_N.
DR InterPro; IPR026300; CWF11_fam.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF5; RNA HELICASE AQUARIUS; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF16399; Aquarius_N_1st; 1.
DR Pfam; PF21143; Aquarius_N_2nd; 1.
DR Pfam; PF21144; Aquarius_N_3rd; 1.
DR PIRSF; PIRSF038901; AQR_cwf11; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:PWY69848.1};
KW Helicase {ECO:0000313|EMBL:PWY69848.1};
KW Hydrolase {ECO:0000313|EMBL:PWY69848.1};
KW mRNA processing {ECO:0000256|PIRNR:PIRNR038901};
KW mRNA splicing {ECO:0000256|PIRNR:PIRNR038901};
KW Nucleotide-binding {ECO:0000313|EMBL:PWY69848.1};
KW Nucleus {ECO:0000256|PIRNR:PIRNR038901};
KW Reference proteome {ECO:0000313|Proteomes:UP000246702}.
FT DOMAIN 28..412
FT /note="RNA helicase aquarius N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16399"
FT DOMAIN 491..657
FT /note="RNA helicase aquarius beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF21143"
FT DOMAIN 705..796
FT /note="RNA helicase aquarius insertion"
FT /evidence="ECO:0000259|Pfam:PF21144"
FT DOMAIN 808..1105
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 1116..1307
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 752..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..774
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1417 AA; 161252 MW; 57389C8934F1C966 CRC64;
MGLQSRQAMA QGLDSRPTVE DFREDNTWVR LAKTHWLEGS KARKVKQDVI KKDLWDPLEA
ENFSFRSLLT LENLNVLEKF LWPTYTEDAS NYHVLLLALL VSVKQREHLP IWGIFSDRPA
DFSNLFHRIL SMSVDPSLGT SSRLSIVSFI IGSFQSVENP LIRKECAPLV SISIWHNLSS
EEARERLLTK SPGLKKAWRA AAKRYDAGDD AAKARMRYER SWLYTMLLDF LRRLNGPEKD
QADNLRYCER LLEFLVDLES QPPTRRYVNT LLKDLNFLSV IRLSQLYRSP DSALFRDLCS
LLKHFSAFAV DDFTGEALSP QVIYDTHCQE LARLQRTCMK YFKDKLMILA LSNYGSIEQR
SELEGQLATL EESELQSLCS HLGFRTDYPK QCQITPDRHL YMEVLLSFYE RKTTFQEAAS
QLSIVPTDEN LYDPTLLRNE TYDGSRPLAI PKLNLQYLSL GDFLWRSFLL YRSEAFFQIR
KDMESVVKRM QPRASRDGKT LAFDGFSRMA IPITKPAIIE VAPPKVGSAK PAFVRAEIAI
EVGRLADHIR MEWESLRPDD VVFLLAVQSD GASKSGLRDP ESPSLKHLRT AEIVQVLDEN
GRPLREPVSG QSNGHRYRPR VRKLLVNLDP AAFKADKDSL TQGKPDVYPL INVIARRKGR
ENNFRSILDT MQKLIVSDIT LPSWIQDIFL GYGDPAGARY TQLPNRLRSV DFRDTFLDWQ
HLIESFPGLT IEPPKEETSS FGPPYILEYV EEPSKVPSAE TSKKRRREQA EKGTAPKSLR
VSTYKPPNPG PYPIDAPKLN AVRFTPAQVE AITSGTQPGL TVIVGPPGTG KTDVATQIIN
NIYHDFPNER TLLIAHSNQA LNQLFQKIVS LDIDERHLLR LGHGEEELET ETSYSKYGRV
ESFLENRNYF LGEVTRLAAS IGAQGAHGNS CETAGYFNTV YIQPAWAKFW DQARSETAST
EEIIATFPFH TYFTDAPQPV LDPNATKDTL LDVAEGCQRH IDKIFSELED IRPFEILRQP
KDKANYLLVK EARIIAMTST HAAMRRQEIA NLGFHYDNVI VEEAAQITEI ESFIPAALQN
MKNGELPLKR VVLCGDHLQN SPIIQNMAFR QYAHFEQSLF LRLVRLGVPV VTLDQQGRAR
PSIAELFRWR YQQLGDLPAV ETAPEFKRAN AGFQFEYQFI NVPDYQGTGE REPTPHFIQN
LGEAEYAVAI YQYMRLLGYP ASKISILATY AGQTALIKDV LNHRCAKNSL FGMPKIVTTV
DKYQGEQNDY VILSLTRTRT VGYLRDVRRL TVALSRARLG LYILGRREVF ESCYELKPAF
DLLLQRPDKL MLAPGEMFPS ARSLEDEVQG TPMESVEHLG QYVFEMTQTK LKAMGEESVV
DNEMYVGDED IALDEDEVML GAGEEGDDDP LHEHTFP
//
