ID A0A317VEQ5_ASPEC Unreviewed; 836 AA.
AC A0A317VEQ5;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Lysophospholipase {ECO:0000256|ARBA:ARBA00013274, ECO:0000256|RuleBase:RU362103};
DE EC=3.1.1.5 {ECO:0000256|ARBA:ARBA00013274, ECO:0000256|RuleBase:RU362103};
GN ORFNames=BO83DRAFT_378914 {ECO:0000313|EMBL:PWY71929.1};
OS Aspergillus eucalypticola (strain CBS 122712 / IBT 29274).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1448314 {ECO:0000313|EMBL:PWY71929.1, ECO:0000313|Proteomes:UP000246171};
RN [1] {ECO:0000313|EMBL:PWY71929.1, ECO:0000313|Proteomes:UP000246171}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 122712 {ECO:0000313|EMBL:PWY71929.1,
RC ECO:0000313|Proteomes:UP000246171};
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De Vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the release of fatty acids from lysophospholipids.
CC {ECO:0000256|ARBA:ARBA00002169}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000960,
CC ECO:0000256|RuleBase:RU362103};
CC -!- SIMILARITY: Belongs to the lysophospholipase family.
CC {ECO:0000256|ARBA:ARBA00008780, ECO:0000256|RuleBase:RU362103}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWY71929.1}.
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DR EMBL; MSFU01000014; PWY71929.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A317VEQ5; -.
DR VEuPathDB; FungiDB:BO83DRAFT_378914; -.
DR OrthoDB; 1997175at2759; -.
DR Proteomes; UP000246171; Unassembled WGS sequence.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProtKB-EC.
DR GO; GO:0102545; F:phosphatidyl phospholipase B activity; IEA:UniProtKB-EC.
DR GO; GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
DR CDD; cd00147; cPLA2_like; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002642; LysoPLipase_cat_dom.
DR PANTHER; PTHR10728; CYTOSOLIC PHOSPHOLIPASE A2; 1.
DR PANTHER; PTHR10728:SF40; LYSOPHOSPHOLIPASE; 1.
DR Pfam; PF01735; PLA2_B; 1.
DR SMART; SM00022; PLAc; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51210; PLA2C; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963, ECO:0000256|PROSITE-
KW ProRule:PRU00555};
KW Lipid metabolism {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103}.
FT DOMAIN 159..700
FT /note="PLA2c"
FT /evidence="ECO:0000259|PROSITE:PS51210"
FT REGION 50..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 836 AA; 92764 MW; F7A9E7EC2DAF419B CRC64;
MGAAKALRLR WTVPPTLLIA LGGGLLYTTS GRTQSNKQLL LQTGPKGFFS TSLNPGSDKR
SDKSSGSSDW NPLGHGSKED PHHDAGSIWT NVLQKFEGVK QAVGTPDWIE LDNIKNYIIP
DWTRLLPLSV QKLQRELSMA PGSLADDIWH EAHDPDINPE ILRKAKVRVG DTLCNEELAY
RQKRQKYATA ALASYLDIPE DEIHPDDVPI IAMCGSGGGL RALVAGTGSY LATQEAGLWD
CVTYTAGVSG SCWLQTLYHS SITGRNFNKM VDHLKNRLGV HLAFPPAALK LLTNAPTNKY
LLSGLVEKLK GDPGADFGLV DIYGMLLAAR LLVPKGELGV CDRDLKLSNQ RYNLASGAHP
LPIYTAVRHE IPVLENQENP EKREKPEDLI KESKNEAWFQ WFEFTPYEFF CEELSAGIPT
WALGRHFHGG VNVKPEEISP IPELRVPALM GVWGSAFCAT LSHYYKEIRP VIKGITGLSG
IDSLIQGKTK DLVRVHPIDP ATIPNYVLGM KDQLPPSCPE SIFRSRHLRL MDAGMSNNLP
IYPLLRPGRD VDVIIAFDAS ADIKQENWLS VVDGYARQRG VKGWPIGAGW PREDEQLKQT
EEMLRQAQNI SQKELANKMA EAQDKSKPNS PTTNQNTTSN NTTTTPPTSA QNKTKNHPST
STDLDYCNIW VGTTQEMVSG QEPPPSKRLF HPQDTDHSES DFHLMRPDAG IAVVYFPLLP
NPSAPELPTS SSLQKSRTPA RKSENTSKAR VSDPAKPLTP YPGTINPDVD DFLSTWNFVY
TPEQIDSVVG LAKANFAQGE DQVKRVVRAV YERKKNDRLQ REERESRQRM EGFVPL
//
