ID A0A317W537_9EURO Unreviewed; 3889 AA.
AC A0A317W537;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=BO94DRAFT_537308 {ECO:0000313|EMBL:PWY80432.1};
OS Aspergillus sclerotioniger CBS 115572.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1450535 {ECO:0000313|EMBL:PWY80432.1, ECO:0000313|Proteomes:UP000246702};
RN [1] {ECO:0000313|EMBL:PWY80432.1, ECO:0000313|Proteomes:UP000246702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 115572 {ECO:0000313|EMBL:PWY80432.1,
RC ECO:0000313|Proteomes:UP000246702};
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De Vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC signaling upon genotoxic stresses such as ionizing radiation (IR),
CC ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC DNA damage, involved in the regulation of DNA damage response
CC mechanism. Required for the control of telomere length and genome
CC stability. {ECO:0000256|ARBA:ARBA00025079}.
CC -!- SUBUNIT: Associates with DNA double-strand breaks.
CC {ECO:0000256|ARBA:ARBA00011370}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWY80432.1}.
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DR EMBL; MSFK01000022; PWY80432.1; -; Genomic_DNA.
DR STRING; 1450535.A0A317W537; -.
DR OrthoDB; 3666795at2759; -.
DR Proteomes; UP000246702; Unassembled WGS sequence.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION/TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000246702}.
FT DOMAIN 2651..3206
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3535..3860
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3857..3889
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 173..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2022..2059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2306..2326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3214..3360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3223..3258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3265..3348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3889 AA; 444357 MW; 65FB9C4C92B911B5 CRC64;
MSSSEGPRGN MERNAERNID IYSTKLGDDK IDIKIRANVA VELRDNIEPL CSGASYPIFL
SKLWPVFKHI LRGEPVFTNL SFEQKLRNCI LETLHRLPMA SPDVEPYADD MVDLLMDLVR
IENEENAVLC MKTIMDLERN QAKATAARVQ PFLALIQEMF QMMEQVVRDT FDTPSQATPS
VMPSTPSATA QTFQSPRPSS PATSVSDLAP DQQANNVLLK GMQSFKVLAE CPIIVVSIFQ
THRTSVATNV KLFVPLIKSI LLLQAKPQEK AHTEAAAQGT IFTGVCKEIK NRAAFGEFIT
AQVKTMSFLA YLLRMYAQQL QDFLPTLPSV VVRLLQDCPR EKSSARKELL VAIRHIINFN
YRKIFLEKID ELLDERTLIG DGLTVYETMR PLAYSMLADL IHHVRDHLTR DQIRRTVEVY
TKNLHDDFPG TSFQTMSAKL LLNMAERISR LDDKREGRYF LVMILDAIGD KFASMNYQFD
NAVKVSKAYK ATRKDLEPSS ERYLAEREHP PDWDEIDIFS ASPIKTSNPR DRGGDPVSDN
IFLFKNLING LKNIFHQLKN CNPDHIQIDP ASVPINWSEV SYGYNAEEVR VIKKLFHEGA
RVFKYYGVDQ SPPEVNYSSP FDFLAGQYTA PMSREEKELL ESFGTVFHCI DTATFHEVFH
SEIPYLHELM FEHGALLHLP QFFLASEATS PAFSGMVLQY LMDRIHEVGT SEMTKAKILL
RMFKLSFMAV TLFSVQNEQV LHPHVTKIVT KCIELSVTAE EPMNYFLLLR SLFRSIGGGR
FELLYKEILP LLEMLLETFN NLLLAARKPQ ERDLYVELTL TVPARLSHLL PHLSYLMRPI
VVALRADSDL VGQGLRTLEL CVDNLTADYL DPIMAPIMDE LMTALWDHLR PHPYNHFHAH
TTMRILGKLG GRNRKFLNHP PDLSFEQFAD DTPSFDIKLV GPSEKRPFPV EIGVDLAIGK
LMEANKTPTA KSSDIYYKQQ AFRMLSSQLK LYIGSENLPE DLASLIRLHA NDLFESKTTA
MPDILERSER SSSITKKLTQ EGSMKKLLKA CIFATTIPEL EQTASAFVAD VCKHFAVVEV
GRALAQARHT RRPFDVSNGE GPVYLDSRVL AEALVESLSS DNAEVRDGAQ AAMQVMKDAA
GIIFGTPERV AKLPFFQHLG RVFCHSCHSE EWFTKAGGSL GIHIFATKLD LGDSWLLDKQ
VEFVRALMYV IKDTPCDLPA STRIRAQETL DLILRRCCKS LSLDDLKNEK SRMYSLCGHF
VYELSHMNKQ VREASRRSFS TIAQVLGCQV HELILPVKDR LLQSIFNKPL RALPFPTQIG
FIDAITYCLS LHNNIVTFND PLNRLMLESL ALADADDESL ASKPNEFKNA EMIVNLRVAC
LRLLSMAMSF QEFGNTPQNT SRARIISVFF KSLYSRSPEV IEAANAGLRD VLTQTNKLPK
DLLQNGLRPI LMNLQDPKRL SVAGLDGLAR LLTLLTNYFK VEIGARLLDH MKVIADDAVL
QKVSFSLVEQ SPPMKIVAAI FNIFHLLPPA ATSFMEHLVN KVLDLEDKLR RTSNSPFRKP
LVKYLNRYPK DSLTFFQSRF KDERFGRFFG QVLADPESEA LRSAVVADTE SFMNAAFGQE
STDGKNTAAI NGIYVAHSIC MYDATKRWLV SHADLRTKLL SSGRDLEKKL RNDKLPANER
LRVEQAEDQL MDIFTKYLTE SVQDLDFLFE VMDGLSADEL KRTLSFPKFI FRHIITNESI
DYRRSVIMRC LDLYSQRACS QKMKTYAFRH LVNPIFAMDV QTTWNSPPNS PKLMDKSMTE
FIQSRLWKPQ LADLSEESNQ AGVDHSRMEL LQLSALLIKY HHQTVQDSRK DIIKFAWNYI
RLEDIINKYG AYVLISYFIA HYETPFKIVV QVYVALLRAH QNEGKALVTQ ALDVLAPVLP
TRTYMANNNA QVQDPRYPLW AKWPRRILAE ETANLQQVMC IFQFLVRQPD LFYDSREHFV
PLIVPSLIKI ASPMSSSNES KKLALNLISL IWHWEEKRVK ASSTPMPNGV HDSPNTKKRK
LEEAQSTASP SPATGSSRDY LVPQDLRAAL TKYLISFITT IAERYPVPAS RIRELPSSKV
PQPAPVPTGD MVKKAVHLLR NLLSQEYWAD LDIELYQKVT EPILAGEKAD KPEEKHVTSM
VNALQVVRVL LASKPDDWIM ARLPLIQKLF EKPLRSDNPE IQDCLHGEED EIDISPKLLP
PVRRVLDALP DDQPEEEDAM DVENSPSEFV TYLSAIATET LSSNNHVSSL NVLWTLSKNK
PAEMDTHIPQ VMKAFSQKLA KEHVAASTAN QGQYTPGTKP PEGVPDQQEY ELGVDLIFKT
IELISVRMSH LGEQRRPFLS VLAQLVERSQ NIKLCSKVLG MVESWIFHST ESWPTLKEKT
AVLHKMLLFE SRQDQTMLKK FLDLVIRIYE DSKITRTELT VRLEHAFLIG TRAQDVEMRN
RFMNIFDRSL TRLASSRLSY VLTCQNWDTL ADSFWLAQAA HLVLGCVDMG SSVRLHPDDF
TVYPVSFLYG NADKDARKAD VMVDIQLEAF VSERKRFIGE IGDVKARDLI EPLCQLQHTD
PNVSYKLWTT LFPIFWSTLS KEDRIDLEKG MVTLITREYH QRQLDKRPNV VQALLEGVVR
ATPRFKIPPH VMKYLSRTYD AWYTAATYLE ETAISPIIDT PTVRESNLDA LVEVYAGLQE
DDFFYGTWRR RCKFVETNAA LSYEQQGMWD KAQQLYENAQ IKARSGAMPF SQGEYYLWED
HWLICAQKLQ QWEILSDFAK HENLNDLLLE SAWRNIENWQ SEGSREQLES LIKSVSDAPT
PRRTFFQAFM ALLQFHIKKE NIQEFNGVCD ESIQLSIRKW LQLPKRITNA HIPILQHFQL
LVELHDASHI CASLSQTNER NLDTKSAELK LLLGTWRDRL PNLWDDINAW QDLVTWRQHI
FQLINATYLS LLPPQTNNVA SNSYAYRGYH ETAWIINRFA HVARKHQMPE VCINQLSRIY
TLPNIEIQEA FLKLREQAKC HYQNPKELNS GLDVINNTNL NYFGAQQKAE FYTLKGMFLA
KLNHVNEANE AFGVALYYEL RLAKAWSEWG QYSDQRFKAD PTDYELASNA VSCYLEAAGL
YKNAKSRKLL SRILWLLSLD NEEGQIARAF ESFKGDTPVW YWITYIPQLL TSLSHREARL
CKAVLVKIAK LFPQALFFLL RTNREDMLNI KKQHDQKQEK LNRVRQQQQQ QQQQASPRPK
ASPATASPLQ NSQSANPSPP TSVPAPSGQQ AVQNQAQPQP QTTPGQVPNA GQVNNQNGPQ
QTPVQGQGQV QAPGQGQVPN QGQPQIQPQG QQGLLQVPGQ NGVAQPNQNA AGAEVEKEPL
KKPWEYSDEI MSGLKTAFPL LALSMETMVD QIHKNFKCPP DEDAYRLIVA LLNDGLAYVG
RMPGSYAQDF KLPPATEANI TRFAETILPA HIRKSFEADF VVKKPTMYEY IQKLRRWRDK
FEEKLDRRPQ SQFLETYSPH LSEFRFLKFD EVEVPGQYLL HKDKNQDFVR IDRFLPDIDL
VRGIGVCHRR LKIRGHDGSV HPFAVQHPAA RHCRREERIL QLFRIFNGLL GKRKESRRRN
LYFHLPLMVP LAPHIRLVRD DPSYISMQGI YEDYCRRVGI NKDEPVMFTM EKMRSLAETK
QNRTNDQQQV LRTEMLTAIQ EKWVPSTIVL DYFQRMYPNF ADFWLFRRQF AYQYAAIAFM
TYVMHMGNRY PNKILISRLT GDIWGSELIP TINPTKAFFY NPEQVPFRFT PNIQTLLGPI
ATEGLFACAL MAIARCLTEP RHELEQQLSV FVRDEMMFWA TAQHRAPLGP PQLRDLVYNN
SDVIVNRAVS LASPPEGNLP ANQTTIDLIS KAVNPQHLAA CDALWMPYL
//