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Database: UniProt
Entry: A0A317W537_9EURO
LinkDB: A0A317W537_9EURO
Original site: A0A317W537_9EURO 
ID   A0A317W537_9EURO        Unreviewed;      3889 AA.
AC   A0A317W537;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BO94DRAFT_537308 {ECO:0000313|EMBL:PWY80432.1};
OS   Aspergillus sclerotioniger CBS 115572.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1450535 {ECO:0000313|EMBL:PWY80432.1, ECO:0000313|Proteomes:UP000246702};
RN   [1] {ECO:0000313|EMBL:PWY80432.1, ECO:0000313|Proteomes:UP000246702}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 115572 {ECO:0000313|EMBL:PWY80432.1,
RC   ECO:0000313|Proteomes:UP000246702};
RG   DOE Joint Genome Institute;
RA   Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA   Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA   Salamov A., Henrissat B., Wiebenga A., De Vries R.P., Grigoriev I.V.,
RA   Mortensen U.H., Andersen M.R., Baker S.E.;
RT   "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT   speciation.";
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC       signaling upon genotoxic stresses such as ionizing radiation (IR),
CC       ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC       a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC       Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC       DNA damage, involved in the regulation of DNA damage response
CC       mechanism. Required for the control of telomere length and genome
CC       stability. {ECO:0000256|ARBA:ARBA00025079}.
CC   -!- SUBUNIT: Associates with DNA double-strand breaks.
CC       {ECO:0000256|ARBA:ARBA00011370}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWY80432.1}.
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DR   EMBL; MSFK01000022; PWY80432.1; -; Genomic_DNA.
DR   STRING; 1450535.A0A317W537; -.
DR   OrthoDB; 3666795at2759; -.
DR   Proteomes; UP000246702; Unassembled WGS sequence.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   CDD; cd05163; PIKK_TRRAP; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003152; FATC_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR003151; PIK-rel_kinase_FAT.
DR   InterPro; IPR014009; PIK_FAT.
DR   InterPro; IPR046807; Tra1_central.
DR   InterPro; IPR046805; Tra1_ring.
DR   PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR   PANTHER; PTHR11139:SF1; TRANSFORMATION/TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR   Pfam; PF02259; FAT; 1.
DR   Pfam; PF02260; FATC; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF20175; Tra1_central; 1.
DR   Pfam; PF20206; Tra1_ring; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 3.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51189; FAT; 1.
DR   PROSITE; PS51190; FATC; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE   4: Predicted;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Reference proteome {ECO:0000313|Proteomes:UP000246702}.
FT   DOMAIN          2651..3206
FT                   /note="FAT"
FT                   /evidence="ECO:0000259|PROSITE:PS51189"
FT   DOMAIN          3535..3860
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
FT   DOMAIN          3857..3889
FT                   /note="FATC"
FT                   /evidence="ECO:0000259|PROSITE:PS51190"
FT   REGION          173..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2022..2059
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2306..2326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3214..3360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3223..3258
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3265..3348
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3889 AA;  444357 MW;  65FB9C4C92B911B5 CRC64;
     MSSSEGPRGN MERNAERNID IYSTKLGDDK IDIKIRANVA VELRDNIEPL CSGASYPIFL
     SKLWPVFKHI LRGEPVFTNL SFEQKLRNCI LETLHRLPMA SPDVEPYADD MVDLLMDLVR
     IENEENAVLC MKTIMDLERN QAKATAARVQ PFLALIQEMF QMMEQVVRDT FDTPSQATPS
     VMPSTPSATA QTFQSPRPSS PATSVSDLAP DQQANNVLLK GMQSFKVLAE CPIIVVSIFQ
     THRTSVATNV KLFVPLIKSI LLLQAKPQEK AHTEAAAQGT IFTGVCKEIK NRAAFGEFIT
     AQVKTMSFLA YLLRMYAQQL QDFLPTLPSV VVRLLQDCPR EKSSARKELL VAIRHIINFN
     YRKIFLEKID ELLDERTLIG DGLTVYETMR PLAYSMLADL IHHVRDHLTR DQIRRTVEVY
     TKNLHDDFPG TSFQTMSAKL LLNMAERISR LDDKREGRYF LVMILDAIGD KFASMNYQFD
     NAVKVSKAYK ATRKDLEPSS ERYLAEREHP PDWDEIDIFS ASPIKTSNPR DRGGDPVSDN
     IFLFKNLING LKNIFHQLKN CNPDHIQIDP ASVPINWSEV SYGYNAEEVR VIKKLFHEGA
     RVFKYYGVDQ SPPEVNYSSP FDFLAGQYTA PMSREEKELL ESFGTVFHCI DTATFHEVFH
     SEIPYLHELM FEHGALLHLP QFFLASEATS PAFSGMVLQY LMDRIHEVGT SEMTKAKILL
     RMFKLSFMAV TLFSVQNEQV LHPHVTKIVT KCIELSVTAE EPMNYFLLLR SLFRSIGGGR
     FELLYKEILP LLEMLLETFN NLLLAARKPQ ERDLYVELTL TVPARLSHLL PHLSYLMRPI
     VVALRADSDL VGQGLRTLEL CVDNLTADYL DPIMAPIMDE LMTALWDHLR PHPYNHFHAH
     TTMRILGKLG GRNRKFLNHP PDLSFEQFAD DTPSFDIKLV GPSEKRPFPV EIGVDLAIGK
     LMEANKTPTA KSSDIYYKQQ AFRMLSSQLK LYIGSENLPE DLASLIRLHA NDLFESKTTA
     MPDILERSER SSSITKKLTQ EGSMKKLLKA CIFATTIPEL EQTASAFVAD VCKHFAVVEV
     GRALAQARHT RRPFDVSNGE GPVYLDSRVL AEALVESLSS DNAEVRDGAQ AAMQVMKDAA
     GIIFGTPERV AKLPFFQHLG RVFCHSCHSE EWFTKAGGSL GIHIFATKLD LGDSWLLDKQ
     VEFVRALMYV IKDTPCDLPA STRIRAQETL DLILRRCCKS LSLDDLKNEK SRMYSLCGHF
     VYELSHMNKQ VREASRRSFS TIAQVLGCQV HELILPVKDR LLQSIFNKPL RALPFPTQIG
     FIDAITYCLS LHNNIVTFND PLNRLMLESL ALADADDESL ASKPNEFKNA EMIVNLRVAC
     LRLLSMAMSF QEFGNTPQNT SRARIISVFF KSLYSRSPEV IEAANAGLRD VLTQTNKLPK
     DLLQNGLRPI LMNLQDPKRL SVAGLDGLAR LLTLLTNYFK VEIGARLLDH MKVIADDAVL
     QKVSFSLVEQ SPPMKIVAAI FNIFHLLPPA ATSFMEHLVN KVLDLEDKLR RTSNSPFRKP
     LVKYLNRYPK DSLTFFQSRF KDERFGRFFG QVLADPESEA LRSAVVADTE SFMNAAFGQE
     STDGKNTAAI NGIYVAHSIC MYDATKRWLV SHADLRTKLL SSGRDLEKKL RNDKLPANER
     LRVEQAEDQL MDIFTKYLTE SVQDLDFLFE VMDGLSADEL KRTLSFPKFI FRHIITNESI
     DYRRSVIMRC LDLYSQRACS QKMKTYAFRH LVNPIFAMDV QTTWNSPPNS PKLMDKSMTE
     FIQSRLWKPQ LADLSEESNQ AGVDHSRMEL LQLSALLIKY HHQTVQDSRK DIIKFAWNYI
     RLEDIINKYG AYVLISYFIA HYETPFKIVV QVYVALLRAH QNEGKALVTQ ALDVLAPVLP
     TRTYMANNNA QVQDPRYPLW AKWPRRILAE ETANLQQVMC IFQFLVRQPD LFYDSREHFV
     PLIVPSLIKI ASPMSSSNES KKLALNLISL IWHWEEKRVK ASSTPMPNGV HDSPNTKKRK
     LEEAQSTASP SPATGSSRDY LVPQDLRAAL TKYLISFITT IAERYPVPAS RIRELPSSKV
     PQPAPVPTGD MVKKAVHLLR NLLSQEYWAD LDIELYQKVT EPILAGEKAD KPEEKHVTSM
     VNALQVVRVL LASKPDDWIM ARLPLIQKLF EKPLRSDNPE IQDCLHGEED EIDISPKLLP
     PVRRVLDALP DDQPEEEDAM DVENSPSEFV TYLSAIATET LSSNNHVSSL NVLWTLSKNK
     PAEMDTHIPQ VMKAFSQKLA KEHVAASTAN QGQYTPGTKP PEGVPDQQEY ELGVDLIFKT
     IELISVRMSH LGEQRRPFLS VLAQLVERSQ NIKLCSKVLG MVESWIFHST ESWPTLKEKT
     AVLHKMLLFE SRQDQTMLKK FLDLVIRIYE DSKITRTELT VRLEHAFLIG TRAQDVEMRN
     RFMNIFDRSL TRLASSRLSY VLTCQNWDTL ADSFWLAQAA HLVLGCVDMG SSVRLHPDDF
     TVYPVSFLYG NADKDARKAD VMVDIQLEAF VSERKRFIGE IGDVKARDLI EPLCQLQHTD
     PNVSYKLWTT LFPIFWSTLS KEDRIDLEKG MVTLITREYH QRQLDKRPNV VQALLEGVVR
     ATPRFKIPPH VMKYLSRTYD AWYTAATYLE ETAISPIIDT PTVRESNLDA LVEVYAGLQE
     DDFFYGTWRR RCKFVETNAA LSYEQQGMWD KAQQLYENAQ IKARSGAMPF SQGEYYLWED
     HWLICAQKLQ QWEILSDFAK HENLNDLLLE SAWRNIENWQ SEGSREQLES LIKSVSDAPT
     PRRTFFQAFM ALLQFHIKKE NIQEFNGVCD ESIQLSIRKW LQLPKRITNA HIPILQHFQL
     LVELHDASHI CASLSQTNER NLDTKSAELK LLLGTWRDRL PNLWDDINAW QDLVTWRQHI
     FQLINATYLS LLPPQTNNVA SNSYAYRGYH ETAWIINRFA HVARKHQMPE VCINQLSRIY
     TLPNIEIQEA FLKLREQAKC HYQNPKELNS GLDVINNTNL NYFGAQQKAE FYTLKGMFLA
     KLNHVNEANE AFGVALYYEL RLAKAWSEWG QYSDQRFKAD PTDYELASNA VSCYLEAAGL
     YKNAKSRKLL SRILWLLSLD NEEGQIARAF ESFKGDTPVW YWITYIPQLL TSLSHREARL
     CKAVLVKIAK LFPQALFFLL RTNREDMLNI KKQHDQKQEK LNRVRQQQQQ QQQQASPRPK
     ASPATASPLQ NSQSANPSPP TSVPAPSGQQ AVQNQAQPQP QTTPGQVPNA GQVNNQNGPQ
     QTPVQGQGQV QAPGQGQVPN QGQPQIQPQG QQGLLQVPGQ NGVAQPNQNA AGAEVEKEPL
     KKPWEYSDEI MSGLKTAFPL LALSMETMVD QIHKNFKCPP DEDAYRLIVA LLNDGLAYVG
     RMPGSYAQDF KLPPATEANI TRFAETILPA HIRKSFEADF VVKKPTMYEY IQKLRRWRDK
     FEEKLDRRPQ SQFLETYSPH LSEFRFLKFD EVEVPGQYLL HKDKNQDFVR IDRFLPDIDL
     VRGIGVCHRR LKIRGHDGSV HPFAVQHPAA RHCRREERIL QLFRIFNGLL GKRKESRRRN
     LYFHLPLMVP LAPHIRLVRD DPSYISMQGI YEDYCRRVGI NKDEPVMFTM EKMRSLAETK
     QNRTNDQQQV LRTEMLTAIQ EKWVPSTIVL DYFQRMYPNF ADFWLFRRQF AYQYAAIAFM
     TYVMHMGNRY PNKILISRLT GDIWGSELIP TINPTKAFFY NPEQVPFRFT PNIQTLLGPI
     ATEGLFACAL MAIARCLTEP RHELEQQLSV FVRDEMMFWA TAQHRAPLGP PQLRDLVYNN
     SDVIVNRAVS LASPPEGNLP ANQTTIDLIS KAVNPQHLAA CDALWMPYL
//
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