ID   A0A317WP08_9EURO        Unreviewed;      1280 AA.
AC   A0A317WP08;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 12.
DE   SubName: Full=5-oxo-L-prolinase {ECO:0000313|EMBL:PWY88224.1};
GN   ORFNames=BO70DRAFT_359691 {ECO:0000313|EMBL:PWY88224.1};
OS   Aspergillus heteromorphus CBS 117.55.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1448321 {ECO:0000313|EMBL:PWY88224.1, ECO:0000313|Proteomes:UP000247233};
RN   [1] {ECO:0000313|EMBL:PWY88224.1, ECO:0000313|Proteomes:UP000247233}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 117.55 {ECO:0000313|EMBL:PWY88224.1,
RC   ECO:0000313|Proteomes:UP000247233};
RG   DOE Joint Genome Institute;
RA   Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA   Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA   Salamov A., Henrissat B., Wiebenga A., De Vries R.P., Grigoriev I.V.,
RA   Mortensen U.H., Andersen M.R., Baker S.E.;
RT   "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT   speciation.";
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the oxoprolinase family.
CC       {ECO:0000256|ARBA:ARBA00010403}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWY88224.1}.
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DR   EMBL; MSFL01000005; PWY88224.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A317WP08; -.
DR   STRING; 1448321.A0A317WP08; -.
DR   VEuPathDB; FungiDB:BO70DRAFT_359691; -.
DR   OrthoDB; 674at2759; -.
DR   Proteomes; UP000247233; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR049517; ACX-like_C.
DR   InterPro; IPR008040; Hydant_A_N.
DR   InterPro; IPR002821; Hydantoinase_A.
DR   InterPro; IPR003692; Hydantoinase_B.
DR   InterPro; IPR045079; Oxoprolinase_fam.
DR   PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR   PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR   Pfam; PF19278; Hydant_A_C; 1.
DR   Pfam; PF05378; Hydant_A_N; 1.
DR   Pfam; PF01968; Hydantoinase_A; 1.
DR   Pfam; PF02538; Hydantoinase_B; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000247233}.
FT   DOMAIN          9..215
FT                   /note="Hydantoinase/oxoprolinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05378"
FT   DOMAIN          234..534
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          546..724
FT                   /note="Acetophenone carboxylase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19278"
FT   DOMAIN          740..1276
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
SQ   SEQUENCE   1280 AA;  138545 MW;  52C6B9F47B1D37D9 CRC64;
     MPGSEKITIS IDRGGTFTDV HAIVPGLPDI ILKLLSVDPG HYQDAPTEGI RQILELVTGE
     SHPRGKPLKL DRIGSLRMGT TVATNALLER KGARSVLLTT KGFRDLLKIG DQSRPNIFDL
     SMARPGVLPE QVVEVNERVV PCHPLADKDC FTEARIVEGT TGEKFRVVKE LDVEELRPVL
     QRLKEQGYQS LSVALVHSFA YPEHERQIGE LAQSMGFSVT LSSKLQPMIK VVPRGMSAAA
     DAYLTPVIKT YIDSISDSFE GGLEKQHECR FEFMQSDGGL VDFRRFSGLK AILSGPAAGV
     VGFAATSWDP TEKTPVIGFD MGGTSTDVSR FDGHLEHVFG SKVAGVLIQS PQLDINTVAA
     GGGSILSWRN GLFYVGPESA SAHPGPACYR KGGPLTVTDA NLFLGRLLPQ YFPHIFGPNE
     DQPLDLEVTT NLFNELTQKI NTERKEKGQS KFTAEEVALG FLKVADESMA RPIRNLTEAR
     GFETASHHLA CFGGAGGQHA CTVAASLGIS RIIIHKFSSV LSAYGLALAE VVKESQEPVS
     TDYSTSHSTL EKRFDGLKEA ATDDMKTQGF AADQVRHELY LNLRYEGSDT SLMILKPEDD
     SDFLEEFRAR HRREFGFNSD RPVLVDDIRV RTIASSKVRE EKSPLVQLRE ATLKDVTNGP
     DDTSKAYFDG YSERIDTPVY PLNKLDKNTR IHGPAVIIDE TQTVVVAPNA VASILETCIV
     IDLKELPGDS AVEAASSGID PIRLTIFGHR FMSIAEQMGR TLQKTSVSTN IKERLDFSCA
     LFSPDGGLVA NAPHVPVHLG SMQFAVRYQH QKWLGNLKDG DVLVANHPSC GGTHLPDITV
     ITPVFDRPGG TEIMFYVASR GHHADIGGIL PGSMPPKSTE LWQEGAAIEG DKIVTNGIFD
     EERMMELLVH KPAQYPGCSG ARCVSDNLSD LKAQIAANTR GITLIQALFA EYGVETVQKY
     MYAIQVTAET AVRNLLKDLH KKFGGQPLEA VDYMDDGTPI KLKVTINGDD GSATFDFAGT
     GPEVYGGWNA PIAITHSAII YCLRCMINAD MPLNQGCLAP INIEVPSPSI LSPTKSAAVV
     GGNVVTSQRI TDVVLKAFRA CAASQGCCNN LTFGTNSKTD PETGKTIPGF GYYETIAGGS
     GAGPTWNGES GIHVHMTNTR ITDPEILEKR YPTLLRQFTL REGSGGKGDH PGGDGVVRDI
     EFLSPMEVSI LSERRVYRPY GLEGGEDAQP GLNLWVTKDV DTGAERVVNI GGKNTVSMKT
     HDRIVINTAG GGGWGAAASA
//