ID A0A317WPP5_9EURO Unreviewed; 1192 AA.
AC A0A317WPP5;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Ras GEF {ECO:0000313|EMBL:PWY86260.1};
GN ORFNames=BO70DRAFT_224527 {ECO:0000313|EMBL:PWY86260.1};
OS Aspergillus heteromorphus CBS 117.55.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1448321 {ECO:0000313|EMBL:PWY86260.1, ECO:0000313|Proteomes:UP000247233};
RN [1] {ECO:0000313|EMBL:PWY86260.1, ECO:0000313|Proteomes:UP000247233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 117.55 {ECO:0000313|EMBL:PWY86260.1,
RC ECO:0000313|Proteomes:UP000247233};
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De Vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWY86260.1}.
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DR EMBL; MSFL01000008; PWY86260.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A317WPP5; -.
DR STRING; 1448321.A0A317WPP5; -.
DR VEuPathDB; FungiDB:BO70DRAFT_224527; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000247233; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000247233};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 57..123
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 725..845
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 905..1148
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 281..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..303
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..542
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1192 AA; 132447 MW; F1A63798A3E61C8E CRC64;
MDPMKRHIAP LKIEKGNFNF HTDRYHHAQH HLEMSPPLTP YNSKDNNMEP TETPRAVFHN
YLRAFYPYHP SGNLSPSTVT LPLDQGDVIL VHSVHTNGWA DGTLLDTGAR GWLPTNYCEA
YDQQPMRPLL KALTDFWDII RGGCGFPLNN AGNQDLVRGL IAGVRYLLQK SECLTRDCML
VTGHDGLRRN RKALLADLSS LVRTTKKFQE VGTGAAMQDD IDYMVDEMLL KAFRIVTRGV
RFLDVWNEDV GLSRTIAELE QQSAQHQQDQ VPLGTETCPI AEPAPSEADT ERNESRLLNR
SRLDMSRAST RLDDALPPRP VSVTTKRISI SHRVSCSAPA AAVRNPNLAS ERLNAAYDAF
LGVLGSFIGL HLHSRSSTEL VVTTEQAVRS CRALLTVVEA TCEHDPQGSG LLEHARDTMY
ERLSELVYAA RDAFRPAHSP DDELVFLPDE GKRLVDAATD CVRAAGNCLA KARLMLEQCG
DFELEAMPQD VAPVAPVAAS PLPDANKTPK SPKTSTFAGD QPPRSQEASL RLPPPPIQIP
KTNNRYSPPT PGLTEDNTPS SFQSFQSRGG AGTPVTANTD QSSFPSTFCT DQSSFPSTIN
TDMSSFPSTT NLCTSLDKLS FSSHDTQPIE ATPHRDSQPK SEFGESFGRG VTSNGSSFTF
NSRLRDSEMS GVSQTSTRAT SPDIGNHYQV PSLKGSISHS TLAEENEETE ANILEKTYAH
ELIFKDGAVM GGSLRALVEK LTAHQSTPDA LFVSTFYLTF RLFATPLDFA ETLVDRFNYI
GDTPHAAGPV RLRVYNVFKG WLESHWRHDC DNNTLEYIVH FANTTLMYNL PSAGRRLAEL
AEKVSMVHGP VVPRLVSSMG KTNTATAQYV HPDTPLPPPI LGKKEINLLK QWKNGDGTIT
ILDFDPMELA RQFTIKESRI FCTILPEELL ATEWMKKSGS LAVNVRAMST LSTDLAHLVA
DSILQLEEPK KRAAIIKHWV KIANKCLELS NYDSLMAIIC SLNSSMISRL KRTWEVVSQK
TKTILEFLRG IVDVSRNYAV LRQRLQNHVP PCLPFVGTYL TDLTFVDHGN QPLRNLPTDE
GEMAVINFDK HVKTAKIISE LQRFQIPYRL AEVPELQAWM QNELIRVRSS GEKGAQTFYR
RSLVLEPREA PQQRNIQPES SSSSILENAK DKFDFLSWTH PSSKAKSVAT NG
//
