ID A0A318ACN3_9MICC Unreviewed; 650 AA.
AC A0A318ACN3;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203};
GN ORFNames=DCC25_06375 {ECO:0000313|EMBL:PXA80387.1};
OS Auritidibacter sp. NML120636.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Auritidibacter.
OX NCBI_TaxID=2170743 {ECO:0000313|EMBL:PXA80387.1, ECO:0000313|Proteomes:UP000247286};
RN [1] {ECO:0000313|EMBL:PXA80387.1, ECO:0000313|Proteomes:UP000247286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NML120636 {ECO:0000313|EMBL:PXA80387.1,
RC ECO:0000313|Proteomes:UP000247286};
RA Bernard K., Pacheco A.L., Burdz T., Wiebe D., Beniac D., Booth T.,
RA Goldenberger D., Seth-Smith H., Egli A., Bernier A.-M.;
RT "Auritidibacter winnipegensis sp. nov. recovered from Human Clinical
RT Materials and Emendation of the Genus Auritidibacter (Yassin et al 2011).";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PXA80387.1}.
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DR EMBL; QHLO01000005; PXA80387.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A318ACN3; -.
DR Proteomes; UP000247286; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00203}; Reference proteome {ECO:0000313|Proteomes:UP000247286};
KW SOS response {ECO:0000256|HAMAP-Rule:MF_00203}.
FT DOMAIN 16..95
FT /note="GIY-YIG"
FT /evidence="ECO:0000259|PROSITE:PS50164"
FT DOMAIN 208..243
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT DOMAIN 259..517
FT /note="UvrC family homology region profile"
FT /evidence="ECO:0000259|PROSITE:PS50165"
FT REGION 468..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 650 AA; 72888 MW; 227F133BDEBE6A69 CRC64;
MADPATYRPR TGDIPTDPGV YRFKDATGRI IYVGKAKNLR NRLTSYFASP HQLSPKTRAM
VTSASGVEWT IVASEQEAIQ LEYTWIKQFT PRYNIMYRDD KSYPYLAVTI NERFPRVMVM
RGDKRPGVKY FGPFHPVKAI RETMDLLLRV FPVRTCSAGV FRRAELSGRS CLMGYIDKCS
APCVGNISEA DHRQLAHDFI SFMNGNIRPY VRELETKMAE AVAELRYEDA ARYRDDIAAL
NKVFERNAVV LPENTQADIF AFADDELEAA FQVFHIRDGR IRGQRGWVVE KVEDVSEQDL
IEQLLQQVYG QLDDQDRIPA EVLVPVLPGE VSGLESWLEE RRGAHVNLRV PQRGAKKDLM
HTVKDNAVEA LRLHKSRRSG DITARSAALK ELQQALGLHE PLLRIECYDI SHTQGTNVVG
SMVVFEDGLP KKRDYRLFNV TGEAARDDTR AMDDVLTRRF KKYLQEQANT PEPFSGQLDP
AELAAEDDQD RQRFSYPPSL VVVDGGPAQV ASAAQALADL GIDDIPVVGL AKRLEELRVP
GDDFPLVLPR SSEGLYLLQR LRDESHRFAI TAHRKRRAKA MTHSALDDIA GLGPAKRKAL
LAEFGSVKKI TAATVDQLQN AQGIGPALAE TIYTALHPDE TQQAEGSQDS
//
