ID   A0A318E4T3_9GAMM        Unreviewed;      1047 AA.
AC   A0A318E4T3;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Cu(I)/Ag(I) efflux system membrane protein CusA/SilA {ECO:0000313|EMBL:PXV63708.1};
GN   ORFNames=C8D93_11517 {ECO:0000313|EMBL:PXV63708.1};
OS   Sinimarinibacterium flocculans.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Nevskiales; Nevskiaceae;
OC   Sinimarinibacterium.
OX   NCBI_TaxID=985250 {ECO:0000313|EMBL:PXV63708.1, ECO:0000313|Proteomes:UP000248330};
RN   [1] {ECO:0000313|EMBL:PXV63708.1, ECO:0000313|Proteomes:UP000248330}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 104150 {ECO:0000313|EMBL:PXV63708.1,
RC   ECO:0000313|Proteomes:UP000248330};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT   most valuable type-strain genomes for metagenomic binning, comparative
RT   biology and taxonomic classification.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PXV63708.1}.
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DR   EMBL; QICN01000015; PXV63708.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A318E4T3; -.
DR   OrthoDB; 9758757at2; -.
DR   Proteomes; UP000248330; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004763; CusA-like.
DR   NCBIfam; TIGR00914; 2A0601; 1.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF19; CATION EFFLUX SYSTEM PROTEIN CUSA; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248330};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        342..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        363..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        390..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        446..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        486..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        528..552
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        874..891
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        898..918
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        924..948
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        983..1004
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1010..1036
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1047 AA;  113765 MW;  1B983289C2C85CAB CRC64;
     MIARLIHWSV HNRFLVLLAT AMLTAWGLYS AANTPLDAIP DLSDTQVIVR TVYPGQAPQV
     VEDQVTYPLT TTLLSVPYAK TVRGYSLFGE SFVYVLFEDG VDLYWARSRV LEYLSQVQGR
     LPPTARAELG PDATGVGWIY EYALVDRTGQ NDISQLRAIQ DWFLKYELKT VPNVAEVATL
     GGFNKQYQIV LDPDRLRAFK LPLETVMDAV QSANAEAGGS VLELAEAEYM VRARGYLKTL
     DDFRDIPVGL GEAGTPILLR DVATVQLGPE TRRGIAELDG EGEVVGGVIV LRSGENAQST
     IEAVKAKLET LKASLPPGVE IVETYDRSAL IERAVENLSH KLLEEFLVVA LICVIFLWHL
     RSALVAIITL PIGILAAFIV MHAQGINANI MSLGGIAIAI GAMVDAAVVM IENAHKKLEH
     WRHDHAGQEL EGEARLKLMA EAAAEVGPAL FFSLLIITVS FVPVFLLEAQ EGRLFTPLAY
     TKTYAMAAAA GLSVTLIPVL MVAFIRGKIV DETANPLNRL LIALYRPVIN QVLAFPRATL
     VIAVAAALAT LWPATRLGSE FMPPLDEGDL LYMPTALPGL AVGKGAQILQ QTDRILKTFP
     EVQRVFGKIG RAETATDPAP LEMVETTVML KPQSEWRAGM TTEKLIEEMD AALKIPGMGN
     VWVQPIRNRI DMLATGIKSP VGIKIAGPDL NVIQQIGNEI ESVVKQVPGT ASAFSERVSG
     GRYVEVVPDR IAAARYGLSI EDVQRIVSIA VGGQNIGETI EGLQRFPINL RYPRELRDSV
     QDLRELPIVT MRGETLTLGS IATVEIADGP PMIKSENARP NGWIYVDIRG RDLGGYVADA
     KRVVAEQVQL PPGYSVAWSG QFEYLERAAK RMKIVVPFTL AVIFLLLYLT FRSAASAALI
     MATLPFALVG GLWLIYALGH HLSVASGVGF IALAGVAAEF GVIMLIYLDN AIREREQRGQ
     MRTVADLREA LIEGAVLRVR PKAMTVAVII AGLLPLFIGA GTGSEVMQRI AAPMVGGMVT
     APLLSMIVLP AAYLLLRGRR LARQVLS
//