ID A0A318JHV7_9BURK Unreviewed; 4271 AA.
AC A0A318JHV7;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:PXX46802.1};
GN ORFNames=DFR42_101378 {ECO:0000313|EMBL:PXX46802.1};
OS Undibacterium pigrum.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Undibacterium.
OX NCBI_TaxID=401470 {ECO:0000313|EMBL:PXX46802.1, ECO:0000313|Proteomes:UP000247792};
RN [1] {ECO:0000313|EMBL:PXX46802.1, ECO:0000313|Proteomes:UP000247792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19792 {ECO:0000313|EMBL:PXX46802.1,
RC ECO:0000313|Proteomes:UP000247792};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PXX46802.1}.
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DR EMBL; QJKB01000001; PXX46802.1; -; Genomic_DNA.
DR Proteomes; UP000247792; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19535; Cyc_NRPS; 2.
DR CDD; cd05931; FAAL; 1.
DR CDD; cd05274; KR_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR040097; FAAL/FAAC.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF00550; PP-binding; 4.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 4.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 254..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 658..733
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 767..1186
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2151..2225
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3605..3680
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4159..4235
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 4236..4271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4236..4265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4271 AA; 465453 MW; F68881A03C17025A CRC64;
MLMRKAYKRT GKQGQFPPCQ LILRETMTNT PAISLSQHPT LVDWIEHHAQ HQPDAEALCF
IGQRTGSTDT SADVRLTYAA LSRRVRNCAA SLQACTNPGD SALILFPSGI DYVVALLACF
YAGVTGVPVN LPGAARVKRV LPKLGDITRD CSPALIISNQ QVTDASGSDL QAFANEHGLR
LLQLEEMQEE NSQTWQRPVI NGAALAFLQY TSGSTGQPKG VINRHGPLLH NLEFLGRLTA
VNTRQASDTV IASWLPLFHD LGLIMGILLP LAYGGRAVYM APMAFAADPL RWLELATRER
ATALPCPSFA LRLCTDEAKT AALRLKDINL ASVTCLMPAA EPVLPAQIES FYTTFAANGL
RRTAIKPAYG LAEATLLVTA HVDDHDPYFI DVDKAKLERG YAVVNPAHNE NTNTGMRRYT
SNGNDFGGQD VRIVDPDTHA ALAEDQVGEI WINGPAVAGG YWNKPELNRD IFSACIASIN
INEEDCKPYL RTGDMGFMHE GHLFVTGRLK DMLLFRGQCH YPNDIEVTSG RSHAAAVPES
GAAFSITLRD EQTEHLVIVQ EVLKQTGGSY QHIVDTIRAS VAEEHQLSSH AIVLIRKGTL
PRTTSGKVRR ATVRQAYLDG SLPVLHQHVL DAQQITEAPA DTALLDTLRP LSLAQRHQHL
RNWLANEAAT ILGTVTARAI HPEASLFNYG LDSMSAARMV ASAAKSLGMS LPDNVIFDHP
SLTELAVHLQ TVLVTQARLP LAADNSSSVS ATPDRDTGKA VPASTDKEAI AVIGMAFRLP
GQDGQDANSD ETFWDMLEQG GCAIRPAPSE RFRTREDIPG FGAYLNHVDQ FDAAFFGMSP
REAMNTDPQQ RLLLEVAWHA LEDAGQRPAA LRGSDTGVFV GIGTGDYGHL PFISGEPSHF
DAYWGTGTSF AAACGRLSFS FGWEGPSMAV DTACSASHSA LHLAVQSLRA RESGLSLAAG
VKLQLLPEVD LVLHKAGMLA LDGRCKTLDA RADGYVRGEG CVVLVLKRLS DALADGDVIR
AVIRDTMVRQ DGAGSSLSAP NGAAQQRLLS LALKKAGLTP TDIDYIELHG TGTRLGDPIE
YQSVADVFRG RDLDDPLWLG SVKTNIGHLE AAAGAAGLVK TILAIEHGKL PPAVELQEVN
PLIDLDIIPA RVPAQTINWP MRQALRRAGV TSYGFAGTIA HVLLEQAPVM ASGKTSEKIT
APQLFLLSAR SAESLRMLAS SHAENLAGCD NLPALARGMA RQREHHNLRA AVLASSFEEL
ASGLQQLIAP GYTATEAIRN PRIGFLFTGQ GSQYSGMARE LYAQQRDFRQ ALDAVDAALA
ADLGMSVITL MHDDAQNERL QQTAFAQPAL FALGYALAKM WQAFGVQPII VLGHSIGEFA
AMVIAGSLTL EQAARLIVKR GALMQALPAG GAMLAARSTP EQALAVLAEL QADHGDEIAI
AAFNGPQDVV FSGSVAAIEA VQALLTAQQL YARPLQVSHA FHSPLLDPML AAWESECARY
VMQAPRIAVC SSLTGELLTQ APDASYWKNH ARQPVRFDQA LQNAASACDI LLEIGPNAIL
SAVAQRNQAA QDWPHAVNCL ASLRRGGSDL VAIGDACAAL YVAGQDFHWD HVFAGSLPSP
RILPRYPFER QSYWLDYDDD APRLPLQLQP QPERAAAKPV DLYIMQWESF TLAENGTHAS
RYFLLGGDLT HTATLAAGLA ATGASTYSLT AGEWPLTATQ LEDSDVVIYL DGWHAQVECA
ALADQQGWQL TEFVKVLQHL QKKPRILLPT NAGQAIAGTS GNPLQASLWG AARALALEYP
GPRWLMADSD AGLLPFASAL PALLPLFGNE EAVALRNGLW LHPRLEPVSA QAHEVAEPPA
LKRDGIYLVA GAYGALGRHA TDWLASRGAR HLVLLARRSA PSGWQARMDL LKAQGIQITH
IDADVADADD MARVFANITS MEQDSGLSLA GVFHCAGTSR FNDLATITNE DYQTVSRAKI
QGAWLLHEHT RSRELDYFVC FTSISGIWGS RLQIPYGAAN AYQDALARMR RHQGLPALAI
AWGPWGGGAG MSEVDEDLLQ LLRAAGIRRL APARYLATLD KLLSGEYITD NGTCVAVDVD
WQQFVPLYAL YNPANTFERC LSASQANTIA VSATADTPSA LHDLDEQARQ AAVHAFVIAE
LARTLRVTPA QLTPDIQLLK LGMDSILVMD FSRRCEAGLG VKCELKAIFE RNTPQGLTDY
LLEQLGKQLP DSQPQKEAEQ IIADPANANT PFPLTELQHA YWIGRHSHYG LGGVACHAYL
EADAPKGLDL DLLERCWNML VARHGALRLV IAEDGQQRVL PKVPDYVLRV ADLTDADQTT
ADAHCTAWRE TMSHQVMDAA QWPLFDLRAS RLPGGAVRLH IGIDMLINDA TSGQIIWEEL
AALYQAKADM QLAGLLPFQI SFRDYVLAKY VHSKQRHTER ESAKAFWLER IPVLPPAPQL
PLRAEALRQT SPTFSRRQQQ LAAPLWQSLR DQAAQAGCTP ASLLITVFAE VLAAWSAEPQ
FTLNLTIFDR LPWHADVPRL LGDFTAVTLL PLDCSEALPF GQRAAAVNGT VLEHLQHRAF
SAVDVMREWN RGRERQDAIA MPVVFTSQLG MNDPTKGAAP DSALGNVVYG ISQTPQVWLD
HQACELDGAL IYNWDAVDAL FQPGTLDAMF NAYHGLLEKL ATQPQSWQEA LPVLLPPSQQ
AIRAQVNASA APMSDFCLDQ LFFEQAQSSP QAIAMIAHEQ QWSYAELADW SLRLTNALLQ
YGAKRSDRVA VVMRKGPEQI AACLGILAAS CVYVPVDADV PAARLQAILD GSHIKLVLTQ
ADCLPIVQEM CAGREVTVLD ASQAATQTWP ASLQQVERAV PDHAYVIYTS GSTGIPKGVL
IDHRGAVNTV LDINRRFDIG HTDRVLGLSS LYFDLSVYDL FGIFAAGAAL VLPAASGTRD
PAHWLDLLLR HRVTVWNSVP ALLELLLDEA EAAGASLAGL RQVFLSGDWI ALGLPARLRT
QAPQARLVAM GGATEASIWS NWFIVPEVLP TQWRSIPYGY PLANQHYRVL DTRLRDCPDH
VSGDLYIGGT GLAIAYENDA AKTAASFITH PVHGERLYRT GDLARYWCDG TLEFLGRRDF
QVKIAGNRIE LGEIESALLS HPGVREAVAD AVGPARGNKR LAAWVVPNAA DTSLYDAFSG
NPVLNNDRWV AVEQAGSQTF AQTYSTQQTE RLEQFWSLMD HIGLCMMRDT LLAAGATSGD
HGQILQMLAP APDLVVLAQR WLNTLDLNAQ YDSESAWNNL TPTALDFGLS RAVLQRLRSG
ATQRLEVLRG QVSALEVFYG ADDTLAPEQM TRMNPLSSLC TSALAAAIRS LTQHLGRPLR
ILEIGARSGA ATRDLLAQLS DCAIDYTLTD PARSLVEQAE QAFAIQDSNP LHSIHCRVFE
HERAAATQGV PEYEFDLLIA FNALHRSRNI PALLHRLRSL LNAGGMLIAP EITRNSDFQL
ATVALLEGGY TQFEDRRKLN GNALLAADAW LDELVQAGFV ASAESGIGSN AGMHLLAARQ
KDTVLRFAPR RLVEHLTTLL PAYMVPQTIL ELDALPLSAT GKVMRQQLPR PEMGGSRRIS
RQAGNDAMPP ANDLVRIWQE LLGVADLHGD DDFFDLGGDS LIAVRLIERV RHGMNAHVAL
SDLFDASSLS AFAERVAKAS PYEDSLPPLL PDVAARYAPF PLTDVQQAYW IGRDESFELG
GVSTHLYAEI EVENLALADL ERGWQQVVTR HDMLRAVINA DGMQQVVQDL PAYHLASHDL
RAASASEVSE WLEITRLELS HEVFDTARWP LFTVRAAQMT DSRVRLFVSL DNLVCDGRSM
RTLLAEWSQF ARNPALQLPP LTASFRDYVM LTQQIELLPS YQRSLAYWHD KLSTLAPAPA
LPLTQYAPED VSPPHFTRRE ASLTAQDTLA LQAQAAAHGV TVNAVLLAAY GEVLANWSAI
PRFTLNLTLF NRPPVHQEID ALVGDFTSLV LLGFDAGITA SFAERAFSMQ RQIWADLEHM
QVSAVRVLRE AARRNRRLNQ VAMPIVFTSG LGVASDGAAE LDWLGEFVYG ISQTPQVWID
QQVVERDGAM VFNWDSVDAL FPEGLLDEMF QAYHGLLLNL AQDSDAWQSR VAMPVNRWPA
STFKSVGDVS TATLPNTSPV IDDKLLRMVS NRLAALLGHD ELAPQTNFFE LGATSLDLIR
LRQQLQADTG LVLSITEVFQ HTSIAALAAH LRSRDQSLES EDISSDEAGQ ARKRQRLDND
RRRKRGQQSK A
//
