ID A0A319A021_ASPLB Unreviewed; 1161 AA.
AC A0A319A021;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Ras GEF {ECO:0000313|EMBL:PYH53097.1};
GN ORFNames=BO96DRAFT_426002 {ECO:0000313|EMBL:PYH53097.1};
OS Aspergillus lacticoffeatus (strain CBS 101883).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=1450533 {ECO:0000313|EMBL:PYH53097.1, ECO:0000313|Proteomes:UP000247441};
RN [1] {ECO:0000313|EMBL:PYH53097.1, ECO:0000313|Proteomes:UP000247441}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101883 {ECO:0000313|EMBL:PYH53097.1,
RC ECO:0000313|Proteomes:UP000247441};
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De Vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KZ821365; PYH53097.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A319A021; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000247441; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 61..127
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 696..816
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 876..1119
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 267..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1161 AA; 129489 MW; 7497B75F07F1F148 CRC64;
MESMKRHIAP LKIEKGNLNY HYDDQQQHYY YQQHNLEMSP PLTPYGNKDD SMEQSETPRA
VFHNYLRAFY PYHPSGNVSP STVTLPLDQG DIVLVHSVHT NGWADGTLLD TGARGWLPTN
YCEAYDQQPM RPLLKALTDF WDIIRGGCGF PLNDAGNQDL VRGLIAGVRY LLQKSECLTR
DCILVTSHDG LRRNRKALLA ELSSLVRTTK RFQEVASGNA TQDEIDYMVD EMLLKAFRIV
TRGVRFLDVW TEEVGLSRTI AELEQQSGYQ QGPLSTLSET RPISEAAGSE ADTERNESRL
MNRSRLDMSR ASTRLDDSQQ TRPVSVTTKR ISVSHRVSTS GPAAIARNPN LASERLNDAY
DAFLGVLGSF IGLHLQSRSS TELVVTTEQA VRSCRALLTV VEATCEHDPQ GSGHLEQARD
TMYERLSELV YAARDAFRPA HSPDDELVFL PDEGKRLVDA ATDCVRAAGS CLAKARLMLE
QCGDFELEAM PQDLPAATSA VTDANKTPQP PKTSTFAGHQ NRSQEASLRL PPPPLQIPNS
INNRYSPPTP GLTDDTTPSS FQSRGGASTP GTDMSSFPST NLLSSSLDKL SFSSHDTQPI
EIPPHRDSQA KSDVSESFGR GITSNGSSFT FNSRLRDSEM SGVSQTSTRA TSPDIGNHYQ
VPSLKGSISH STLAEETEEG EANILEKTYA HELIFKDGQI MGGSLRALVE KLTAHQSTPD
AMFVSTFYLT FRLFATPIEF AETLVDRFNY IGDTPHTAGP VRLRVYNVFK GWLESHWRHD
CDNSALEYIV NFASTILMNN LPSAGKRLVE LADKVSMVHG PVVPRLVSSM GKTNTATAQY
VHPDTPLPPP ILGKKEVNLL KQWKNGEGTI TILDFDPMEL ARQFTIKESR IFCAILPEEL
LATEWMKKSG SLAVNVRAMA TLSTDLTHLV ADSILQLEEP KKRAAIIKHW VKIANKCLEL
SNYDSLMAII CSLNSSMISR LKRTWEVVSQ KTKTTLEYLR GIVDVSRNYY VLRQRLQNRV
PPCLPFVGTY LTDLTFVDHG NQALRTLPTD EGDMAVINFD KHMKTAKIIS ELQRFQIPYR
LTEVPELQAW MQNELVRVRS SGEKSLQTFY RRSLVLEPRE VPQARMQPES SSSSILENAK
DKFDFLSWTH PSKSKSVATN G
//
