ID   A0A319AUA8_ASPLB        Unreviewed;      1054 AA.
AC   A0A319AUA8;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   22-FEB-2023, entry version 12.
DE   RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN   ORFNames=BO96DRAFT_356731 {ECO:0000313|EMBL:PYH61280.1};
OS   Aspergillus lacticoffeatus (strain CBS 101883).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=1450533 {ECO:0000313|EMBL:PYH61280.1, ECO:0000313|Proteomes:UP000247441};
RN   [1] {ECO:0000313|EMBL:PYH61280.1, ECO:0000313|Proteomes:UP000247441}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 101883 {ECO:0000313|EMBL:PYH61280.1,
RC   ECO:0000313|Proteomes:UP000247441};
RG   DOE Joint Genome Institute;
RA   Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA   Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA   Salamov A., Henrissat B., Wiebenga A., De Vries R.P., Grigoriev I.V.,
RA   Mortensen U.H., Andersen M.R., Baker S.E.;
RT   "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT   speciation.";
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC       (CIA) complex, a multiprotein complex that mediates the incorporation
CC       of iron-sulfur cluster into apoproteins specifically involved in DNA
CC       metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC       adapter between early-acting CIA components and a subset of cellular
CC       target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU367072}.
CC   -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC       {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR   EMBL; KZ821339; PYH61280.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A319AUA8; -.
DR   OrthoDB; 38995at2759; -.
DR   Proteomes; UP000247441; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039920; MET18/MMS19.
DR   InterPro; IPR024687; MMS19_C.
DR   InterPro; IPR029240; MMS19_N.
DR   PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR   PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR   Pfam; PF12460; MMS19_C; 1.
DR   Pfam; PF14500; MMS19_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU367072};
KW   DNA repair {ECO:0000256|RuleBase:RU367072};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          40..297
FT                   /note="MMS19 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14500"
FT   DOMAIN          545..988
FT                   /note="MMS19 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12460"
SQ   SEQUENCE   1054 AA;  116583 MW;  76B4B4F3D5323AA8 CRC64;
     MSALQTFLLV VDHDKQEAKQ IAERIAQDVE TKKTTLIEVV QSLGEYINDE DSILRGKAVS
     YLTAVIRALP PKFLSRQQIQ VLTTFFCERI EDGGAVPGLE TLQKLDRFNK ALAEEVAQAI
     FERFEELQSR SQSQRFQVYQ LLNELMINHR AALHDMGDES LVGIVNLMTG EKDPRNLMLV
     FSILKVVMVE WDVSNHAEAL FDSVYNYFPI TFRPPPNDPY GITAQDLKDR LQDCISANSL
     FAPHAVPSLL DKLDSTSPNV KKDALNALIA CVKLYDPNTV SKYSITIWET LKFEILNAQE
     EFLSELSLQV LSSIAQRLSE GVTQISDQLP LAQFLRPITK ECSEQLQEPQ QKQAKPAQQI
     LSSTSAASAA SFTLIVQTVV APLLTIYQEA DGIAKQRALL DTLTVLFDSA IQVFGAWTSR
     DSEPSLSNPL LEFKDQFSDI FGQALMGVIK EEVLFRISAL KGFLRLSTLR NYFQDNEVGL
     FVQYLDEILL KEESVGRDDL KKEAIAALTE ISKYKPRLIL DITFPAFVAT LPDSDDGSNP
     EYITTLETLA QISVERDIFD TLVRRLLSKL SILLQKDDPG SVDYPRAILL TILYVMNQRK
     LDETPNLDLY YDKIVVSLCR SAATAALGKA PNNILTDATV LDVLGRLCNV IIRSLPQSKH
     DEVVSNIYTL FASADGFQQV PFTPSPTDSH RRTMILSTYL LASLPRDTKN LPPCTPPVMS
     DLLTDIATRC TTETETATQL AFLRHLALYI NKHLSKEDLD LATTLFDSLL PQTTQDPHLT
     TSTIKTLFWI SKALILRLSP KTTQILTTLL NLLSSSSEAT STTAARGFAI LLKDDEVLSP
     TNHANVRLLS KQRVFTTLTP LISARIREVN VAGTASTTHI KPAHLTALSG ILSTIPPTLI
     MPELPTLLPL LLQSLDLQSA DSQPVRAATL ETLAVIIRDN GVSVIEECGH VQSLVTRLLK
     TAEHAPTTGA INGPRLRVDA LKCLFLLAQT PDSGAADAPK VAKAGKLSPL LPVKNQVLRA
     LRMVLDDPKR DVRKAAVDAR GAWLRGVDDA AEDD
//