ID A0A319AXL9_ASPLB Unreviewed; 1060 AA.
AC A0A319AXL9;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Protein HIR {ECO:0000256|RuleBase:RU364014};
GN ORFNames=BO96DRAFT_366936 {ECO:0000313|EMBL:PYH56258.1};
OS Aspergillus lacticoffeatus (strain CBS 101883).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=1450533 {ECO:0000313|EMBL:PYH56258.1, ECO:0000313|Proteomes:UP000247441};
RN [1] {ECO:0000313|EMBL:PYH56258.1, ECO:0000313|Proteomes:UP000247441}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101883 {ECO:0000313|EMBL:PYH56258.1,
RC ECO:0000313|Proteomes:UP000247441};
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De Vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|ARBA:ARBA00002677,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
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DR EMBL; KZ821350; PYH56258.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A319AXL9; -.
DR OrthoDB; 5478541at2759; -.
DR Proteomes; UP000247441; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 20..47
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 67..108
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 128..169
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 170..211
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 747..979
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 440..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1060 AA; 114501 MW; 8D4901672EE6DEED CRC64;
MHIIKPVWLT HGGERKDFEV YSCDVSPDGS RLVTAAGDGY VRIWSTEAIC NTDDPENASK
PKQLASMSNH SGTIHTVRFS PNGKYLASGA DDKIVCIYTL DANPPSHAST FGSNEAPPVE
NWRTIRRLIG HDNDVQDLGW SYDSSILVSV GLDSKVVVWS GTTFEKLKTL SIHQSHVKGI
TFDPANKYFA TASDDRTVRI FRFTSPAPNS SAHDQMNNFI LEQTISAPFS NSPLTAYFRR
CSWSPDGMHI AAANAVNGPV SSVAIINRGS WDGDINLIGH EAPVEVCAFS PRLYSPQPIT
KPTVDSQGHA VHNSVTVIAC AGGDKSLSIW ITSNPRPIVV AQELAAKSIS DLAWSPDGKC
LYATALDGTI LAVRFEDGDL GYAMEMEENE RSLTKFGTNR KGAGITETTD GLLLEEMSKA
GEIKGVEGRM GALMGDDHAA ADSKVNGKPG SGASNGVTPA PAPSPTPDTQ KSQPNGTAGT
PAAQEPEKPD PYQAKLERLK QRPTYTKDGK KRIAPLLVSG AGAAESSLPQ ARLMASVSSQ
VKADTPQSIV DLSKPFDGLP KGGLAALLFG NKRKLAQLEG DDDGHVEKRV ALASQNGATP
ILASTPDGLL PAQPQPAPTG QQQTPEFIRP AVMNPCMAIS QLRLAVPKVR SQIVRAIDPT
GKPTEPNASG ESNKSRVDVV FEARNPSPAS LTGRAVDREP VRLTLFRGEQ PLWQDFLPRT
VLLVTGNLSM WAAACEDGSV YIWTPAGRRL VSALVLEAQP VILECNGPWI LCISAVGMCY
VWNVKHLSSP HPPISLQPVL DAAVHTLGAH PSAAPAITNA RINSEGRVVV ALSNGEGYSY
SPSMYTWQRI SESWWAVGSQ YWNTTEAPVG NLQSTDSQDK DAKAAVSAGI VPFLERNTTN
ETLLRGRAYF LQRLIKVLLS REGYESFESS VSIAHLENRL AAALSLGAKE EFRLYLSMYA
KRIGAEGLKM KVEELLKGLI GGLFEEEDAD AIRRLQDNEQ DDRNWRESSE TLCGWPREVL
LKEVILALGK HRDLQRVTVP YAKLLGVVDN ESEAGDAMET
//
