ID A0A319BIE6_ASPLB Unreviewed; 1479 AA.
AC A0A319BIE6;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
DE AltName: Full=Mediator complex subunit 13 {ECO:0000256|ARBA:ARBA00032008, ECO:0000256|RuleBase:RU364134};
GN ORFNames=BO96DRAFT_366049 {ECO:0000313|EMBL:PYH57062.1};
OS Aspergillus lacticoffeatus (strain CBS 101883).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=1450533 {ECO:0000313|EMBL:PYH57062.1, ECO:0000313|Proteomes:UP000247441};
RN [1] {ECO:0000313|EMBL:PYH57062.1, ECO:0000313|Proteomes:UP000247441}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101883 {ECO:0000313|EMBL:PYH57062.1,
RC ECO:0000313|Proteomes:UP000247441};
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De Vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex.
CC {ECO:0000256|ARBA:ARBA00025661, ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
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DR EMBL; KZ821348; PYH57062.1; -; Genomic_DNA.
DR OrthoDB; 9289at2759; -.
DR Proteomes; UP000247441; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF11597; Med13_N; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 1..359
FT /note="Mediator complex subunit Med13 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11597"
FT DOMAIN 974..1144
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1154..1468
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 397..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1314..1356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..771
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..930
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1314..1337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1479 AA; 160731 MW; 6D30098273C15756 CRC64;
MDFPGGSITN IRAIDGFSHI YWRIYTDDPG ESPTNGYAIL KHLSRLKDLE LQLRDRNCLV
SSYPRRLCLW VFSATPGFES LSPLSPNNGK DDSGRLAIGS ATLKVSSSGN VSSLELVKNL
STETQNAPGA AGSQRPNAIT PFATIYASFI SAVSGAVSLQ LIRQRNAIPL GSRTLFTVVE
KDGCDNSHVT ENDVVLAPSL TTLQVQLTSA GKLTVALQTV SQAGLTRLLI PEDDPAGIHD
TPPGTDLWLS PSGSIARLVA ANPSRLNAAS PYPSNVGGPG NEKSSPATRK QWKVNVLWWL
SNFGLPVDGI DDEAWVEVEV WEPFYSRLAG EVWRPNDEGA SVLPLKRILW PAIYCFRRTK
SASSEFYGEM EGVSSIAGDP LDFAEKWRVT EKLSFAEASP KPPSVHQEPP TRDQDASSPD
LLNLPEGIES LSRASQYPDL QTASLVYPTP PDGATATGLN PMVTSDTFAE EIEQNSNFMQ
QDRQNHHRQL SKERIGTDVI SFGPSAGLVV GSGLYDTNDD DDLFGEINEK DFGAKGITDA
DFSFFDDPDF DRGGVGEQAE PVQELSGFMD TDEPEIQPTV DSQASPEHTP AMNIASAQLS
PVVETADLQH EKTPQEAKAP VFTPQEDKPR TISPPLSPVE VKKILFPESV PESPRLAKKG
QGPGYYSAVA FKQNMSLWDQ KYGADGKFGF NIRGIERKKG PDTVTSDIPT VGLPRHSGKV
KSGTSKDPDS YGSPYSEEMQ DSSSDSDMSS SASADSDESA SESGLSPATF STRKRKRTRS
NSGTSLALSQ DKTIIRTDQE TSAQRPEDSV FLGNFLSTFS DWSMAGYFSV AQNQVSPLLI
RKDIQVQIAQ LLVDQVTQSS LHHRIDGTLG LLDYADQGCS PETFRGDAAF MSGMERLDLN
SFVSLQDSNA LSPSSSNGSN SRQSAQRRET GKGTIVKIPP PHLRVRRGKD FLETLPPAIS
FWETFGLEPA HGQKDILAYC IHPHFAAGAA DTFLERLGLV YSGCNLGEHC RGESSNVFDR
GLGSWNTSPS ADSRYSEAIQ SLKSICGVLG SAFLSTPPSK DSNIVVYIVN PFTHAAALVD
ICAAFWSLFQ QYVAEADKQQ TRQLNELVLQ IIPLDFVTSA ESLVVPPQAE YLNLALEVYS
RCPPKSSEVG PVNCAPPVLL AEPIPRSIGF KLSSEGSSPL QEGKHLHIAC SRSLDQRWLS
VAWSDNFGAL QRNMSYCLRY RNSVAARPLP EVRGEIWKAT RDIMDTIQTR WKIIIVSTDP
VDQDEVDTWT NFADQYGKAR STTLDLAILG ANIPSDLHLE PPYLPIPLSM FNQQPSSTPV
ATPNLGGGVS SPDQFGTAPT PPGGWGGPAS ASTPTDALPE VESESLLTDI YDETWGVVLS
HRLNSSPHQT EYRPALASGY LLRRKGSTDG DGLYTMSVNI LFARRSPSSY DALLREILGM
YRDLATLARA RGTRTVQQGT LPWHVATAIN AQSLLSYAL
//