ID A0A319CD86_9EURO Unreviewed; 627 AA.
AC A0A319CD86;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=MATE efflux family protein {ECO:0000313|EMBL:PYH83124.1};
GN ORFNames=BO82DRAFT_46305 {ECO:0000313|EMBL:PYH83124.1};
OS Aspergillus uvarum CBS 121591.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1448315 {ECO:0000313|EMBL:PYH83124.1, ECO:0000313|Proteomes:UP000248340};
RN [1] {ECO:0000313|EMBL:PYH83124.1, ECO:0000313|Proteomes:UP000248340}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 121591 {ECO:0000313|EMBL:PYH83124.1,
RC ECO:0000313|Proteomes:UP000248340};
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De Vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199}.
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DR EMBL; KZ821691; PYH83124.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A319CD86; -.
DR STRING; 1448315.A0A319CD86; -.
DR VEuPathDB; FungiDB:BO82DRAFT_46305; -.
DR OrthoDB; 661905at2759; -.
DR Proteomes; UP000248340; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR11206:SF153; ETHIONINE RESISTANCE-CONFERRING PROTEIN 1; 1.
DR PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR Pfam; PF01554; MatE; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248340};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 194..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 558..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 587..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 627 AA; 68676 MW; F1D68A7E18B4ABB2 CRC64;
MTPRDSDFHS PRMSDEHHYL SRSPLARSAI ARDLEDYADD EGSMLTTDDD DDASETSTIR
AIGSQPGTRA HSLAGSYQRP SYFTTVSRAT VVPYRPEQEG LTRRERDQAI EDERNLLTDN
HFIEPSRKKS RRSASESAPS TEETALLGGE GSSRAPQYDS VDSEEIDRKW EEAVTAGLIQ
TTWKREAQVI GKNAAPLVFT FLLQYSLTVA SIFTLGHLGK KELGAVSLAS MSANITGYAI
YQGLATSLDT LCAQAYGSGK KKLVGLQMQK MVFFLWTISI PIVILWFFAD KVLVRIVPER
EVAELAGLYL KVVALGAPGY ACFESGKRFV QAQGLFSASL YVLLVCAPLN AVMNYVFVWQ
FGWGFVGAPI AVAITDNLMP LFLFLYVYFV AGSECWNGVT RRALRNWGPM IKLALPGLLM
VEAECLAFEV LTLASSYLGT TPLAAQSILS TISSITFQIP FPVSISGSTR VANLIGATLV
NAAKTSAKVT MVGAVIVGLL NMLLLSSLRY YIPRLFTSED EVIELVAQVL PLCAAFQLFD
ALAANCNGIL RGIGRQEIGG YVQLFCYYAI AMPISFGTTF ALDWGLFGLW SGVALALMLV
SIIEGFFLTQ TNWNRSVEDA LKRNSMN
//
