ID A0A319D726_9EURO Unreviewed; 491 AA.
AC A0A319D726;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Nuclear membrane fusion protein Kar5 {ECO:0008006|Google:ProtNLM};
GN ORFNames=BO71DRAFT_400031 {ECO:0000313|EMBL:PYH93030.1};
OS Aspergillus ellipticus CBS 707.79.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1448320 {ECO:0000313|EMBL:PYH93030.1, ECO:0000313|Proteomes:UP000247810};
RN [1] {ECO:0000313|EMBL:PYH93030.1, ECO:0000313|Proteomes:UP000247810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 707.79 {ECO:0000313|EMBL:PYH93030.1,
RC ECO:0000313|Proteomes:UP000247810};
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for nuclear membrane fusion during karyogamy.
CC {ECO:0000256|ARBA:ARBA00003389, ECO:0000256|RuleBase:RU368082}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU368082}. Nucleus membrane
CC {ECO:0000256|RuleBase:RU368082}.
CC -!- SIMILARITY: Belongs to the KAR5 family. {ECO:0000256|ARBA:ARBA00010473,
CC ECO:0000256|RuleBase:RU368082}.
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DR EMBL; KZ825901; PYH93030.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A319D726; -.
DR STRING; 1448320.A0A319D726; -.
DR Proteomes; UP000247810; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000742; P:karyogamy involved in conjugation with cellular fusion; IEA:UniProtKB-UniRule.
DR GO; GO:0048288; P:nuclear membrane fusion involved in karyogamy; IEA:UniProtKB-UniRule.
DR InterPro; IPR007292; Nuclear_fusion_Kar5.
DR PANTHER; PTHR28012; NUCLEAR FUSION PROTEIN KAR5; 1.
DR PANTHER; PTHR28012:SF1; NUCLEAR FUSION PROTEIN KAR5; 1.
DR Pfam; PF04163; Tht1; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU368082};
KW Karyogamy {ECO:0000256|ARBA:ARBA00022459, ECO:0000256|RuleBase:RU368082};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368082};
KW Nucleus {ECO:0000256|RuleBase:RU368082};
KW Reference proteome {ECO:0000313|Proteomes:UP000247810};
KW Signal {ECO:0000256|RuleBase:RU368082};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368082};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368082}.
FT TRANSMEM 473..490
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368082"
SQ SEQUENCE 491 AA; 54676 MW; E02EB4CBAE1A134E CRC64;
MDALSIPDKN SIGDVDLLSS LNKSNRKQDV LFQEALGLLE TMKSSPSCNR MAVSKMVTSC
QSIGGKPEKT NPDTHVTLEH IRSLYAARLA ICELNEAGAA VPSQCFSVAI SSPQKRRIFG
ISSHYNPRFN DVESIPKGQL ESCLNSLESR PQWWTSYSNS RQNAVVICQA ARIEIEKAEL
LELHKSIVQG SIKLDRGLQE AMELATAENT RHKEFVQSVE DMRGRLMQEM DNTELCLKAA
FQRVYHDAEA YVGGVMGSVS SAIQRVHDTT TLLEKDIENA SSEARSLRQS LQFLHDEAME
RNEQMVSTQY RDSLTNNELV LSLKSSLEAL LNGDLDKLSL TVQSFGSSLE WLSGRIIQIL
QQEHSLSERL QSLDISLSES QLIATELRRI QLQHNEAIQS NSQLQEHLQT NMRISQALLD
KIIATAANLQ TMVDETTSRY RSSPVFGGFL GSYSTWTIIS LLVGAIGALN PKLAIIMLIV
CIFHFSITKT L
//
