ID   A0A319DQ56_9EURO        Unreviewed;       943 AA.
AC   A0A319DQ56;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Sodium/calcium exchanger protein {ECO:0000313|EMBL:PYH81392.1};
GN   ORFNames=BO82DRAFT_383687 {ECO:0000313|EMBL:PYH81392.1};
OS   Aspergillus uvarum CBS 121591.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1448315 {ECO:0000313|EMBL:PYH81392.1, ECO:0000313|Proteomes:UP000248340};
RN   [1] {ECO:0000313|EMBL:PYH81392.1, ECO:0000313|Proteomes:UP000248340}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 121591 {ECO:0000313|EMBL:PYH81392.1,
RC   ECO:0000313|Proteomes:UP000248340};
RG   DOE Joint Genome Institute;
RA   Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA   Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA   Salamov A., Henrissat B., Wiebenga A., De Vries R.P., Grigoriev I.V.,
RA   Mortensen U.H., Andersen M.R., Baker S.E.;
RT   "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT   speciation.";
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC       family. {ECO:0000256|ARBA:ARBA00008170}.
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DR   EMBL; KZ821702; PYH81392.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A319DQ56; -.
DR   STRING; 1448315.A0A319DQ56; -.
DR   VEuPathDB; FungiDB:BO82DRAFT_383687; -.
DR   OrthoDB; 5482417at2759; -.
DR   Proteomes; UP000248340; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR   PANTHER; PTHR12266:SF0; MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN; 1.
DR   PANTHER; PTHR12266; NA+/CA2+ K+ INDEPENDENT EXCHANGER; 1.
DR   Pfam; PF01699; Na_Ca_ex; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248340};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        105..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        136..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        175..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        208..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        239..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        711..729
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        741..763
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        775..795
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        807..824
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        844..870
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        891..915
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        921..942
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          113..251
FT                   /note="Sodium/calcium exchanger membrane region"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
FT   DOMAIN          780..934
FT                   /note="Sodium/calcium exchanger membrane region"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
SQ   SEQUENCE   943 AA;  103616 MW;  B97203940E0C7190 CRC64;
     MLSRLISRDN RISRQRRFSV RPFFWSIILL TFLGLSSWTL RRLTHEPAVP DLWRLRQRDN
     TVECRLVRQV QDQCSFIRTN CPDDQDGLIS YLELYYCTLA NAKPLALTVI ISWLSLLFST
     IGIAASDFLC IDLSTLASVL GLSESLTGVT FLAFGNGSPD VFSTFAAMRS NSGSLAIGEL
     LGAASFITSV VAGSMALVRP FKVARRSFVR DVGYFVVAVS FSMFLLADGR LHVWESATMV
     ALYCFYVVLV VTWHWYILRR RRAYERNLAA RSHFHIPENQ ELDIEEIEDD DPGIASESTS
     LLHGEDFNAL ERSDAGNWQG EEDDETRNRY LAEIRDNMRV FRPIARRRNT LNPIRPSLVG
     ALEFQSILTS LQKSRNLHSD APPVNLDQYS DNEEMATSYV YSDNVSVASH PHASRPLASD
     RLHPNQARVP TRTRAVSANA AVDLKLDTSI LESNSRQPLL TVRQPSVNSQ AIGDTHQPDC
     IPQSPTLLAP PELFHLPTYQ SSHSHPSSPL PISPRDSPIS PFPPLLDGMG PVSSRAPSIR
     LPPATSPTEP LYFQDGVEVN GDNQIKTSAT SWATSWSSFQ SIIAILFPTM VGWKYKSIWE
     RLLGVIAAPS VFLLTITLPV IEAAQSSPDA GGFSVVITPA DNVNNPAPLV ALPEDSPLLH
     ALDYEPRAED AIHSSRKSQC APPQSRLDSE IPVIEEGAGS CTTATKEWCS WLVWVQLFTG
     PFFVALITWT ALDPDLKLRS LLLPFLVSLL FSLVCCTALI ISTRHCSASQ PPKEWRPFLA
     LLGFVVAIFW IATIATEVVN LLKTLGVILN ISDSLLGLTV FAVGNSLGDL VADITVARLG
     YPVMALSACF GGPMLNILLG IGLGGLYMTV NARPGTMEAH GGSYEIEVSK VLVISGATLL
     ITLLGLLIVV PLNGWRMDRK IGWGLMVLWG ISTLGNVVAE ILS
//