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Database: UniProt
Entry: A0A319ELI1_ASPSB
LinkDB: A0A319ELI1_ASPSB
Original site: A0A319ELI1_ASPSB 
ID   A0A319ELI1_ASPSB        Unreviewed;       854 AA.
AC   A0A319ELI1;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Protein arginine N-methyltransferase {ECO:0000256|PIRNR:PIRNR015894};
GN   ORFNames=BO78DRAFT_163738 {ECO:0000313|EMBL:PYI11177.1};
OS   Aspergillus sclerotiicarbonarius (strain CBS 121057 / IBT 28362).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1448318 {ECO:0000313|EMBL:PYI11177.1, ECO:0000313|Proteomes:UP000248423};
RN   [1] {ECO:0000313|EMBL:PYI11177.1, ECO:0000313|Proteomes:UP000248423}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 121057 {ECO:0000313|EMBL:PYI11177.1,
RC   ECO:0000313|Proteomes:UP000248423};
RG   DOE Joint Genome Institute;
RA   Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA   Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA   Salamov A., Henrissat B., Wiebenga A., De vries R.P., Grigoriev I.V.,
RA   Mortensen U.H., Andersen M.R., Baker S.E.;
RT   "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT   speciation.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. {ECO:0000256|PIRNR:PIRNR015894}.
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DR   EMBL; KZ826319; PYI11177.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A319ELI1; -.
DR   STRING; 1448318.A0A319ELI1; -.
DR   Proteomes; UP000248423; Unassembled WGS sequence.
DR   GO; GO:0016274; F:protein-arginine N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 1.
DR   Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR025799; Arg_MeTrfase.
DR   InterPro; IPR007857; Arg_MeTrfase_PRMT5.
DR   InterPro; IPR035075; PRMT5.
DR   InterPro; IPR035248; PRMT5_C.
DR   InterPro; IPR035247; PRMT5_TIM.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR10738; PROTEIN ARGININE N-METHYLTRANSFERASE 5; 1.
DR   PANTHER; PTHR10738:SF0; PROTEIN ARGININE N-METHYLTRANSFERASE 5; 1.
DR   Pfam; PF05185; PRMT5; 1.
DR   Pfam; PF17286; PRMT5_C; 1.
DR   Pfam; PF17285; PRMT5_TIM; 1.
DR   PIRSF; PIRSF015894; Skb1_MeTrfase; 2.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51678; SAM_MT_PRMT; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000256|PIRNR:PIRNR015894};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248423};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PIRNR:PIRNR015894};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR015894}.
FT   DOMAIN          39..365
FT                   /note="PRMT5 TIM barrel"
FT                   /evidence="ECO:0000259|Pfam:PF17285"
FT   DOMAIN          372..596
FT                   /note="PRMT5 arginine-N-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF05185"
FT   DOMAIN          599..852
FT                   /note="PRMT5 oligomerisation"
FT                   /evidence="ECO:0000259|Pfam:PF17286"
FT   REGION          651..674
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          817..840
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        821..835
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        566
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015894-1"
FT   ACT_SITE        575
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015894-1"
FT   BINDING         400
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015894-2"
FT   BINDING         409..410
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015894-2"
FT   BINDING         471
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015894-2"
FT   BINDING         498..499
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015894-2"
FT   SITE            403
FT                   /note="Critical for specifying symmetric addition of methyl
FT                   groups"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015894-3"
SQ   SEQUENCE   854 AA;  93854 MW;  C816A862C6DFA8B8 CRC64;
     MESFSNPEDM APSFCIGQHE SARKHPITAA IVQAAHESNY DMLTAPITTE AFHSRILTLL
     GSKPNAPLTP AANGTLMTTD NIRPLEIPPL TPADSHLTPD DTMSQLVGVT SSWIDLCSPD
     PLIADISRQV FMREVAYAAF CGLGYLLIPG PKLHHGDIHS EGVMYYARAI QDAINLAPYI
     QFHIWTTMVD SPDSEVDGIA DLSRLARPEF LGDPLAGQSS KVDPFGTWDA WDIIRRTCRY
     HSRLVVALSM PRHLPPMSVQ SRWYSEPVHL LTIDAQAFIK NQKGYPVLSK THQALIGRLM
     RLRTPPWILL CDVGQLPGVD GEETPGTKLP ALSGSDYPSL TQAAVSNKKH YDPTPHLSYL
     RNLQQRQPSR SAMERFGVGY QDYLQAPLQP LTVNLESITY EVFEKDPIKY KWYERAIAKA
     LSDWESEGKP TSNPDGRVVV VVVGAGRGPL VSRALQASVD TGVKIDLWAV EKNTNAFVLL
     QRHNEQKWGG QVKLVQSDMR SWKGPQVEKK DDSGVQTGPV GQTLGIEDSL LYNTNEEQGS
     AQAPQPAAAP PVTEFVPTTI DILVSELLGS FGDNELSPEC LDGVTHLLNP VHGISIPASY
     TAHLTPIAAP KLHADVMNQA VSNPAAPETP YVVMLHAIDF LSTNQPSAAA LMNSSHGGAR
     QSARDSISTL PGSGETPIPF VQTTWSFEHP NRHIPPQLPS TSTISNAHNV RRTRLSFPVY
     NRGVCHGLAG YFETVLYRDV ELSTNPVTMD TKSADMISWF PIYFPLKTPL NVPDNGEVVV
     TMYRQTDDRK VWYEWMVEVF AVEGSEEEVV MSGGKAVSPA AGSLHQQQQR SRGGRRVRVG
     TSELHSSIKE GCLM
//
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