ID A0A319EU71_ASPSB Unreviewed; 912 AA.
AC A0A319EU71;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Ras guanyl-nucleotide exchange factor RasGEF {ECO:0000313|EMBL:PYI05009.1};
GN ORFNames=BO78DRAFT_318922 {ECO:0000313|EMBL:PYI05009.1};
OS Aspergillus sclerotiicarbonarius (strain CBS 121057 / IBT 28362).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1448318 {ECO:0000313|EMBL:PYI05009.1, ECO:0000313|Proteomes:UP000248423};
RN [1] {ECO:0000313|EMBL:PYI05009.1, ECO:0000313|Proteomes:UP000248423}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 121057 {ECO:0000313|EMBL:PYI05009.1,
RC ECO:0000313|Proteomes:UP000248423};
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KZ826362; PYI05009.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A319EU71; -.
DR STRING; 1448318.A0A319EU71; -.
DR Proteomes; UP000248423; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000248423}.
FT DOMAIN 406..531
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 659..897
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 893..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 912 AA; 100671 MW; 162ADC5E8CEFA056 CRC64;
MTSQSTRRER ASSDKAQAVP VPQRPGLPSR TISAPVGGLY RLESTRTAME SGNKVDRTLV
EEDESPPSAG GNGVPSSRDE TTPKPSFPHV SIAVVGPDHV GKSTFIETAL DMKHPLSSRS
TTKKMSLDGT VYLVRLMEID TLEVSIGSDG EVSWPLLGSD SPPTVDGVLV LHDVTQPASF
PEITGLLDSL TASGIPFTLV ASKCDIQPPD SPVEPVLGGY EIHRTSPDSP RSQKMCIALV
LRSVINSKYD FIDFPSNSDA TPDWHHSRAN SETPTAVFTG AAGGPITGAL DPGVDGYGVD
RQPTDPAPSA NLASNGQAFR YARSNSHPVR PHTPPSGPRL ASRKQSASGE SSPSKDLNRQ
HRLHTAWRNS GGSDAFSNFL EMGEEFDGPR SAPSSPGSKD QTPSEGSSHE TGLTFDELVD
RLVAQPMSKQ DSKFASIFLC LYRKFAAPST LLNALINRFE RNELDITDQL DRIAVQQRLL
GVMAQWVSEY PGDLAYPKTR KRITDFVTTL EKSHFYMFAA KEVGAYLEGN AEDDNIGWPY
RDGDVEEVDS ADPPFQFSGR SSPSIFLGAP PLGDEGEEEE EDPIYNMSAL DLSEGAAEPA
SRLSGSMSNS FTSDKPGTVA SQSFTHLNID SAQREAHSLD LTPRVPLTKV QWRLLMEIPD
EDFARELTRI DWIMFNSFRP RDLVRHVSIS GLEKDKIQSL KHVNRMIKQF NHVAFFVASV
ILLRDKPKHR AKALEKFMNI ALKLRRLNNY NSLGAVIAGI NGTPVHRLSQ TRDLVPVQTQ
KDFMRLVILM GTQKSHFAYR LAWDNSFAER IPFLPLHRRD LVSAEEGNRT FVGDTKTRIN
WRKFEVMGEV VLGIQRSQKT SYPLMAKYEE VERMILEIKL SGDDEDLYSR SMQVEPSAGG
DTGRKKFGWL RS
//
