ID A0A323V8K1_9ACTN Unreviewed; 519 AA.
AC A0A323V8K1;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=Bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase {ECO:0000313|EMBL:PZA20891.1};
DE SubName: Full=Uroporphyrinogen III methyltransferase/synthase {ECO:0000313|EMBL:MBB3677987.1};
DE EC=2.1.1.107 {ECO:0000313|EMBL:MBB3677987.1};
DE EC=4.2.1.75 {ECO:0000313|EMBL:MBB3677987.1};
GN ORFNames=DMO24_13140 {ECO:0000313|EMBL:PZA20891.1}, FHX36_003722
GN {ECO:0000313|EMBL:MBB3677987.1};
OS Modestobacter versicolor.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Modestobacter.
OX NCBI_TaxID=429133 {ECO:0000313|EMBL:PZA20891.1, ECO:0000313|Proteomes:UP000247602};
RN [1] {ECO:0000313|EMBL:PZA20891.1, ECO:0000313|Proteomes:UP000247602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CP153-2 {ECO:0000313|EMBL:PZA20891.1,
RC ECO:0000313|Proteomes:UP000247602};
RA Gundlapally S.R.;
RT "Draft genome sequence of Modestobacter versicolor CP153-2.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:MBB3677987.1, ECO:0000313|Proteomes:UP000580718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16678 {ECO:0000313|EMBL:MBB3677987.1,
RC ECO:0000313|Proteomes:UP000580718};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PZA20891.1}.
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DR EMBL; JACIBU010000001; MBB3677987.1; -; Genomic_DNA.
DR EMBL; QKNV01000134; PZA20891.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A323V8K1; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000247602; Unassembled WGS sequence.
DR Proteomes; UP000580718; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:MBB3677987.1};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:PZA20891.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000247602};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:PZA20891.1}.
FT DOMAIN 14..217
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 269..499
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 519 AA; 52893 MW; 9B1226D7B2C2E931 CRC64;
MTRSRKQNGN GKGTVVFVGA GPGDPELLTG RATAAIAGAD QVLVDADVAA AVVEAVREAH
PDLELTTVTG EPAEVAKGAV AAAKNGNVVV RLVAGDPFTS DAVVKEALAV TRTSVAFDVV
PGVAVGTAVP AYAGVPLGAS SVHADLRPVD AAVDLAALAA AATGTGSPLV LQANAEQLAT
TAAALVDGGL SGNTSVVVTT EGTGTAQKSV AGKLSAVAEK TAGLDALTGP VVVTVGAVVD
KRAKLSWWES RPLFGWRVLV PRTKEQAGDM SERLRAYGAV PVEVPTIAVE PPRSPAQMDR
AVKGLVTGRY GWIVFTSTNA VRAVREKFAE LGLDARAFAG VKVACVGQQT ADAVREFGIV
PELVPTGEQS SEGLLADFPP YDDVFDPIDR VLLPRADIAT ETLAAGLKER GWEIDDVTAY
RTVRAAPPAA AVREAIKGGG FDAVCFTSSS TVRNLVGIAG KPHARTVVSV IGPATAASAT
EFGLRVDVQP EIAAVGPLVD ALAEFAQARR AEAEGGEGQ
//
