ID A0A323VE40_9ACTN Unreviewed; 726 AA.
AC A0A323VE40;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=MMPL family transporter {ECO:0000313|EMBL:PZA22323.1};
DE SubName: Full=RND superfamily putative drug exporter {ECO:0000313|EMBL:MBB3676219.1};
GN ORFNames=DMO24_05615 {ECO:0000313|EMBL:PZA22323.1}, FHX36_001954
GN {ECO:0000313|EMBL:MBB3676219.1};
OS Modestobacter versicolor.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Modestobacter.
OX NCBI_TaxID=429133 {ECO:0000313|EMBL:PZA22323.1, ECO:0000313|Proteomes:UP000247602};
RN [1] {ECO:0000313|EMBL:PZA22323.1, ECO:0000313|Proteomes:UP000247602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CP153-2 {ECO:0000313|EMBL:PZA22323.1,
RC ECO:0000313|Proteomes:UP000247602};
RA Gundlapally S.R.;
RT "Draft genome sequence of Modestobacter versicolor CP153-2.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:MBB3676219.1, ECO:0000313|Proteomes:UP000580718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16678 {ECO:0000313|EMBL:MBB3676219.1,
RC ECO:0000313|Proteomes:UP000580718};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PZA22323.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JACIBU010000001; MBB3676219.1; -; Genomic_DNA.
DR EMBL; QKNV01000037; PZA22323.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A323VE40; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000247602; Unassembled WGS sequence.
DR Proteomes; UP000580718; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000247602};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 179..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 583..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 664..687
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 179..328
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT DOMAIN 521..686
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 726 AA; 74648 MW; 854F4CACB18EB110 CRC64;
MAGLLDRLGR FSFRRRWSVV VLWLLVLAGA VTAAVTSEGP VNTRATIPGI ESQDAFDLLA
ERFPDTPSDS ATATLVFVAP AGGQLDSPAN RAAVDTALAT VAASPQVARV TPPAAGTSIS
ADGSTGVASV TYDVPSAEVT DESRAVLEEA VDQARAAGLT AEMRGSALKS PTAMSATELL
GVAIAAVVLL MTFGSLVAAG LPLLTAVIGV AVSFLGVWAV AGPLGMAITS GMLALMLGLA
VGIDYAMFVV SRYQEERQKE DDAETAAGRA VGTAGSAVVF AGTTVVIALA GLSVVGIPSL
MKMGLAAAGA VVVAVLVALT LVPALLGMAP NRVRSRAQRR NGRTTPRVPV ARAWMRLVLR
RPLLVTVAGV AVLAAVAVPA LSLQLGTPGD ASLPTTATER RAYDLRAEAF GPGSNGPLTV
VVDARGASDP QTAVTAVADD LAATEGVASV SPPTFNEQGD TAVLTAVPTT GPTDERTEQV
VESLRDARPG VERDQGVSYE ITGTTALDID MAQKTQSALV PYVALVVGLA VLLLLVVFRS
IWVPVTAAAG FLLSLSASIG VIVAVFQWGW AGDLLGVEQT GPVMSLMPIL LVGIVFGLAM
DYEVFLVSRM REAHVHGVPA RQAISTGFAQ SSKVVVAAAV IMIAVFGGFA AASEPLIKMV
GLGLAAAVFF DAFVVRLTLV PAVLQLLGER AWELPRWLDR RLPQVDVDGA NLGPAEARPD
LALTSR
//
