ID   A0A327QVK3_9BACT        Unreviewed;       348 AA.
AC   A0A327QVK3;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Membrane fusion protein (Multidrug efflux system) {ECO:0000313|EMBL:RAJ08361.1};
GN   ORFNames=LX64_01009 {ECO:0000313|EMBL:RAJ08361.1};
OS   Chitinophaga skermanii.
OC   Bacteria; Bacteroidota; Chitinophagia; Chitinophagales; Chitinophagaceae;
OC   Chitinophaga.
OX   NCBI_TaxID=331697 {ECO:0000313|EMBL:RAJ08361.1, ECO:0000313|Proteomes:UP000249547};
RN   [1] {ECO:0000313|EMBL:RAJ08361.1, ECO:0000313|Proteomes:UP000249547}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23857 {ECO:0000313|EMBL:RAJ08361.1,
RC   ECO:0000313|Proteomes:UP000249547};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT   (KMG-II): from individual species to whole genera.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000256|ARBA:ARBA00009477}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RAJ08361.1}.
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DR   EMBL; QLLL01000002; RAJ08361.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A327QVK3; -.
DR   OrthoDB; 9811754at2; -.
DR   Proteomes; UP000249547; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 2.40.30.170; -; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR   InterPro; IPR043602; CusB_dom_1.
DR   InterPro; IPR032317; HlyD_D23.
DR   PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR   PANTHER; PTHR30386:SF26; TRANSPORT PROTEIN COMB; 1.
DR   Pfam; PF00529; CusB_dom_1; 1.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000249547};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          51..296
FT                   /note="RND efflux pump membrane fusion protein barrel-
FT                   sandwich"
FT                   /evidence="ECO:0000259|Pfam:PF16576"
FT   DOMAIN          297..342
FT                   /note="Cation efflux system protein CusB"
FT                   /evidence="ECO:0000259|Pfam:PF00529"
SQ   SEQUENCE   348 AA;  38535 MW;  B4C9D9337517590C CRC64;
     MKKNNADKFI VTLTKWLSII LLIAMIVWGG IYFFNGYRYI QTNDAQVDAY LSPVNAKVGG
     YISRIYYKDN QQVHKGDTLV LIELDEYALK RNAASAELMS AQAKMSILAA NEATQLKSIE
     VIKAQLPGAK AKHDQLQSEF NRYKRLLAEE ATTPQKFENI STSLAITQSD FNQTKAALQV
     AESTLKYLGA QRLAIQAEIK TKEALLERQE LDIKYTVITA PFDGQVGKKS IQEGQLIQPG
     QTVAFLVNQS EEKWIIANFK ETQVSHFEIG QPVTIAVDAF PGESFSGAIE SISPTTGARY
     SLLPPDNATG NFVKIIQRIP VRIKLTGIQG SLTKLSAGMN AHVYVLKD
//