ID   A0A327WK50_9ACTN        Unreviewed;      1020 AA.
AC   A0A327WK50;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:RAJ91893.1};
GN   ORFNames=K377_00662 {ECO:0000313|EMBL:RAJ91893.1};
OS   Streptomyces sp. PsTaAH-137.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1305830 {ECO:0000313|EMBL:RAJ91893.1, ECO:0000313|Proteomes:UP000249376};
RN   [1] {ECO:0000313|EMBL:RAJ91893.1, ECO:0000313|Proteomes:UP000249376}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PsTaAH-137 {ECO:0000313|EMBL:RAJ91893.1,
RC   ECO:0000313|Proteomes:UP000249376};
RA   Currie C.;
RT   "Biomass-degrading enzyme discovery via genome sequencing of insect-
RT   associated Streptomyces.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RAJ91893.1}.
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DR   EMBL; QLLY01000001; RAJ91893.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A327WK50; -.
DR   OrthoDB; 9772207at2; -.
DR   Proteomes; UP000249376; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          530..608
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1020 AA;  112124 MW;  11DBE532A40611BE CRC64;
     MHSDRDIVER RLRRVLDERI RPAVHAVSVP LEVGVWQVPG EPVPVADGLA ADYRPTAAGA
     HWGPAWTTSW FRLSGRVPEE WAGRRIEAVV DLGFDPSEPG FSAEGLAYRP DGTAVKALNP
     RNTWLPVTEQ AAGGEEFTCF VEAAANPLVM HSGPDNHTFA ITPLGGRAPW LDEPGAPGGE
     PLYRLRRLDL AVFDAEVYEL VHDMEVLDQL MRELPEQSPR RWQILRALSN ALDAVDLQDI
     GGTAPAAREI LAPALAAPAG AGEHRVSAIG HAHIDTAWLW PLRETVRKVA RTVSNVTQLM
     DERPEFRFVM SQAQQLAWLK EHRPEVYERA QEKAKTGQFV PTGSLWVEPD TNITGGEALA
     RQFIHGKRFY LEEFGVETED MWLPDTFGYN AAMPQLMKLA GVRWFLTQKI SWNTTNKFPH
     HTFWWEGIDG TRIFSHFPPV DTYNSDLSGA EVAHSVRNFQ DKGGANRSLA PFGYGDGGGG
     PTREMLARAE RLADLEGSAR VSIEKPGDFF ARALEEYPDA PVWVGELYLE FHRGTLTSQI
     ATKQGNRRSE HLLREAELWA ATAALRTGAE YPYEALDRLW KTVLLHQFHD ILPGTSIAWV
     HREAEETYRQ IAAELGELIG VAQAALAGPA GADGSEVVFN AAPHARGGAA ALGGAVRTRR
     EPATVTPVAD GAGHVLDNGL VRIAVDERGL VTSAYDIDAD REALPPGRVA NLLQLHQDFP
     NQWDAWDVDA FYRNTVTDLT DAESVTVVDG ALKVVRAFGA SRVEQTLSLA PGARRLDVDT
     VLDWHETEKM LKAAFPLDVR ASHSTAQVPF GHVERPTHTN TSWDAAKFEV CAHRFLHVGE
     RDWGAALVND STYGHDVTRD VREDGGTTTT VRLSLARAPR FPDPDTDQGT HRLRYALVIG
     AGVEDAIREG YHLNLPERTV PGSAEVKPLV SVGSPAVVVE TVKLADDRSG DVVVRLYEGH
     GGRATALLTP GFRIASATAT DLLERPRAAD EPSCSVTEEG VRLRLRPFQI LTVRLVPERS
//