ID A0A327Z158_9ACTN Unreviewed; 683 AA.
AC A0A327Z158;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=RND superfamily putative drug exporter {ECO:0000313|EMBL:RAK28040.1};
GN ORFNames=B0I29_121136 {ECO:0000313|EMBL:RAK28040.1};
OS Actinoplanes lutulentus.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1287878 {ECO:0000313|EMBL:RAK28040.1, ECO:0000313|Proteomes:UP000249341};
RN [1] {ECO:0000313|EMBL:RAK28040.1, ECO:0000313|Proteomes:UP000249341}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.7090 {ECO:0000313|EMBL:RAK28040.1,
RC ECO:0000313|Proteomes:UP000249341};
RA Whitman W.;
RT "Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of
RT soil and plant-associated and newly described type strains.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RAK28040.1}.
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DR EMBL; QLMJ01000021; RAK28040.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A327Z158; -.
DR OrthoDB; 2365435at2; -.
DR Proteomes; UP000249341; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000249341};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..683
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016346586"
FT TRANSMEM 148..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 508..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 614..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 173..305
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT DOMAIN 511..639
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 650..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 71373 MW; 53EC479DDF33A0F5 CRC64;
MRRAWATLLL ALVIGGAILA FAGSTTTDND PTASLPSSAE STKVAQLQKE LPSGRTNPAL
IVIAKGGEAL TDADLAGVTK LGEPILSEDR KAAIITVPLA ATGNADETIT KVQELRDQLK
TDLPAGVTAQ VTGGAGFSAD LSDSFSGANT RLLLVTVIVV TVLLLITYRS PILWIVPLFV
VGLADQLAAK AIAIFSQHTD LAINGSTTGI VTVLVFGAGT NYALLLISRY REELHKHEDR
FEAMRKALRG AGPAILASSG TVVLALLTLL LASLKSNAAL GVTAAVGVAI ASLFALVVLP
AALVICGRKL FWPFIPKVGQ DGAESERGFW GKVGRTVVRR PVAVTAFAVV VLGILSLGAL
GTKVGLSQTE QFRVEAESVA GLETLSKYFP AGAAGPATVL TEPAKADQVV KILEDTPGVV
QVRIAEQNTD LASISAVMQA APDTAEAFDT IRAMRDNLNG EALVGGTVAT ALDTRDAARH
DLKMIVPVIL GVVFLVLVLL LRALVAPVLL MLTVVLSFMA SLGAGSWLFR HVFDYPALDN
SVPLFAFLFL VALGVDYNIF LVTRAKEETP ARGTRDGMVH ALAVTGAVIT SAGILLAAVF
AVLGVLPVVT LTQIGIIVGI GVLLDTLLVR TVLVPALATL TGDRFWWPGK PQAKTPPVDA
GGSRERTDWD SVNRSKLTTP ADS
//
