ID A0A327ZAD2_9ACTN Unreviewed; 1150 AA.
AC A0A327ZAD2;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=WD40 repeat protein {ECO:0000313|EMBL:RAK35533.1};
GN ORFNames=B0I29_1096 {ECO:0000313|EMBL:RAK35533.1};
OS Actinoplanes lutulentus.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1287878 {ECO:0000313|EMBL:RAK35533.1, ECO:0000313|Proteomes:UP000249341};
RN [1] {ECO:0000313|EMBL:RAK35533.1, ECO:0000313|Proteomes:UP000249341}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.7090 {ECO:0000313|EMBL:RAK35533.1,
RC ECO:0000313|Proteomes:UP000249341};
RA Whitman W.;
RT "Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of
RT soil and plant-associated and newly described type strains.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RAK35533.1}.
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DR EMBL; QLMJ01000009; RAK35533.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A327ZAD2; -.
DR OrthoDB; 134501at2; -.
DR Proteomes; UP000249341; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 4.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19879:SF1; CANNONBALL-RELATED; 1.
DR PANTHER; PTHR19879; TRANSCRIPTION INITIATION FACTOR TFIID; 1.
DR Pfam; PF13676; TIR_2; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00255; TIR; 1.
DR SMART; SM00320; WD40; 12.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50104; TIR; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000249341};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT TRANSMEM 188..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..126
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REPEAT 594..626
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 766..800
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 232..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1150 AA; 124117 MW; 3E2921AF61B57B91 CRC64;
MPFDGFISYS HAADGRLAPA VQRGLHRLAR PWHRRRALWI FRDQTGLAVT PGLWSSIQTA
MDGSQYFVLL ASPEAARSPW VNKEIEHWVA TKSPQRILPV LTDGEWRWDS AIGDFTGDST
AVPEALRGVF VEEPLYLDLR WARDDLHLTL RHARFRDSIA QLAAPMHGVS KDELESEDVR
QHRRARRLWS AATAMVLVLA LVASLTGVLA MRNAGRANAS AVEARRQQQI AFEQRGSAER
ATEESLRQQE NAQTQEQRAQ TAAEETRRQG VLAGEQRALA DQAAADAALQ KGNAEQQQEY
ARREKENAQR SAEDARREQE DARRSAEDAR REKENARRQQ EDARRYAEDA QRQKENAQQQ
EENAQRSAED AQRSAEEAKR QQELADQAEG RARQQEQLAQ QYQEQAQLAI EERQRQEKIA
REQEQLAREA AEEARRQREE AALQRRIAIN QRLIDRARAM IEYDPQKALM LGVAAQRLHA
GALSGDQLSH LVMSTHYAGA LADVVEVAVV ANGVLAAAGP DGTVALWDIS RPARVVRLAA
VPTGGSAGKT LVASPDGRTL AVFEGLSPVV LWDVSDPARP ARLTELADAA GTVAVAFSPD
GRTVATSNRD KSTTLWDVVR GRAPAVLSTL PGTRSLTFGP DGKIAVTSGA TATVWNLADR
TAPVQLTTIS KALADGAVVF SPKLPVVVIE EIDGYVVPWD MRNPALPKRG SSLEAATGDA
ALSRLAFSAD GLMLALSDSS GTTRLRNLSL GAIAGQTSLI GRVATLTGRD GPIRSAALSA
DGKMLITSGE RRTATLWNTR GAFGRETIAA LVRPDPADVV GVAFGPDGRS VIAADAPGTT
VTWDLTDPAK PVQGAAVQLN SGRIQLMDQS RDGHTLAVGG MDEVVTLIDI SRPAEPAVLT
RITDPGDVST FTFSPDGSVL AVGRTNGRTS LYDMANPARP APLAELTDRG FLNGLSFSGD
GRTLAVAAGY NVSLWDLTDR SAPVRHTELS LGASTLAVAL SPDGRTLAAG VGWGGSASLW
DIADPARPHR LATMKDAESV VMWLGFSPDG TVLATGGISE AHLWEVTDRT SPVRFSTLVH
NQLRSRDLVF SSDGHTLAAA GSRSVTLWDY SVPKALSADP GTHACTLTGR GLNAEEWAQY
VPELPYQATC
//
