ID   A0A328C2F2_9DELT        Unreviewed;       785 AA.
AC   A0A328C2F2;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=DL240_16365 {ECO:0000313|EMBL:RAL20604.1};
OS   Lujinxingia litoralis.
OC   Bacteria; Deltaproteobacteria; Bradymonadales; Lujinxingiaceae;
OC   Lujinxingia.
OX   NCBI_TaxID=2211119 {ECO:0000313|EMBL:RAL20604.1, ECO:0000313|Proteomes:UP000249169};
RN   [1] {ECO:0000313|EMBL:RAL20604.1, ECO:0000313|Proteomes:UP000249169}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B210 {ECO:0000313|EMBL:RAL20604.1,
RC   ECO:0000313|Proteomes:UP000249169};
RA   Li C.-M.;
RT   "Lujinxingia marina gen. nov. sp. nov., a new facultative anaerobic member
RT   of the class Deltaproteobacteria, and proposal of Lujinxingaceae fam.
RT   nov.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RAL20604.1}.
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DR   EMBL; QHKO01000009; RAL20604.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A328C2F2; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000249169; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 3.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:RAL20604.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000249169};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          8..468
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   COILED          433..460
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   785 AA;  87625 MW;  3D070C8805B87E51 CRC64;
     MPTQPIDVAL HKTTQERYLN YAMSVITSRA LPDVRDGLKP VQRRILYAMY TNLRLTHDAR
     FRKSAAIVGE VMGKYHPHGD QSIYDAMVRM AQNFSLRYPL VDGHGNFGSV DGDSAAAMRY
     TEARMMPLAS ELLDEIKKQT VPYRPNYDGT VQEPVVLPAQ VPNLLINGAT GIAVGMATNI
     PPHHLGEVVD ALIALIDSPS LTIDDIVGEI IQGPDFPTGG VLLNSREELR EIYHQGSGTL
     VTRAQWEVER DGARRFIVVT AIPYYVNKAT LIEKIAEHII QGKLPQVVDV RDESTADVRV
     VLELKRGASA DVAMAYLFKH TPLEDRFHVN LTCLVPSENP DVAQPAKVDL KMMLRYFLDF
     RMEVVTRRIE HELAQLLRRI HILEGFEAIF GDLDEAIRII RASEGKADAA KKLMAYFGID
     AEQTEAILET KLYRLAKLEI ELIRAELAEK RAEAARLQGL LGSEARRWDL IRRELVAIRG
     AYGDARRTLV DAPVKELEYS EEAYIIAERC WMMVSRQGRI KRQKSYTDLS TIRVREGDEM
     GWVLPGSTRD AVIFFTNMGR GYTMRIDDVP STTGYGDPVQ ASFDFADGER VVGVVTTDAR
     VLRKMTPDQP SLVGGGEEND EDDVQLVGIA RSGQAVRFSL ESYTEPSTVK GRLFMRLGRG
     DEVVNVENCD GSELVALASR DGRALMFPVR EISHVKGPAK GVRAITLEGK DQVLDFTLCR
     ERLDGLEVET NRGAREIIRA TKAQYAPSSR GNKGKLVIQR GHLIRAHRPP VEIIPGDEDE
     AGEEE
//