ID A0A328PIA4_9EURY Unreviewed; 400 AA.
AC A0A328PIA4;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 10.
DE RecName: Full=Protein-export membrane protein SecD {ECO:0000256|HAMAP-Rule:MF_01463};
GN Name=secD {ECO:0000256|HAMAP-Rule:MF_01463};
GN ORFNames=DPC56_03570 {ECO:0000313|EMBL:RAO79396.1};
OS Methanothermobacter tenebrarum.
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX NCBI_TaxID=680118 {ECO:0000313|EMBL:RAO79396.1, ECO:0000313|Proteomes:UP000249782};
RN [1] {ECO:0000313|EMBL:RAO79396.1, ECO:0000313|Proteomes:UP000249782}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MCM B 1447 {ECO:0000313|EMBL:RAO79396.1,
RC ECO:0000313|Proteomes:UP000249782};
RA Pore S.D., Dagar S., Dhakephalkar P.K.;
RT "Draft genome sequence of hyperthermophilic methanogen Methanothermobacter
RT tenebrarum sp. MCM-B 1447.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in protein export. {ECO:0000256|HAMAP-
CC Rule:MF_01463}.
CC -!- SUBUNIT: Part of the protein translocation apparatus. Forms a complex
CC with SecF. {ECO:0000256|HAMAP-Rule:MF_01463}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01463};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01463}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SecD/SecF family. SecD subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01463}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_01463}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RAO79396.1}.
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DR EMBL; QLOE01000003; RAO79396.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A328PIA4; -.
DR OrthoDB; 146638at2157; -.
DR Proteomes; UP000249782; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0065002; P:intracellular protein transmembrane transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006605; P:protein targeting; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.3220; -; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR HAMAP; MF_01463_A; SecD_A; 1.
DR InterPro; IPR022813; SecD/SecF_arch_bac.
DR InterPro; IPR022646; SecD/SecF_CS.
DR InterPro; IPR048631; SecD_1st.
DR InterPro; IPR024912; SecD_arc.
DR InterPro; IPR048634; SecD_SecF_C.
DR PANTHER; PTHR30081:SF8; PROTEIN TRANSLOCASE SUBUNIT SECF; 1.
DR PANTHER; PTHR30081; PROTEIN-EXPORT MEMBRANE PROTEIN SEC; 1.
DR Pfam; PF07549; Sec_GG; 1.
DR Pfam; PF21760; SecD_1st; 1.
DR Pfam; PF02355; SecD_SecF; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_01463};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01463};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927, ECO:0000256|HAMAP-
KW Rule:MF_01463}; Reference proteome {ECO:0000313|Proteomes:UP000249782};
KW Translocation {ECO:0000256|ARBA:ARBA00023010, ECO:0000256|HAMAP-
KW Rule:MF_01463};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01463};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01463};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01463}.
FT TRANSMEM 238..259
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01463"
FT TRANSMEM 266..288
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01463"
FT TRANSMEM 294..315
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01463"
FT TRANSMEM 336..359
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01463"
FT TRANSMEM 365..386
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01463"
FT DOMAIN 59..110
FT /note="Protein translocase subunit SecDF P1"
FT /evidence="ECO:0000259|Pfam:PF21760"
FT DOMAIN 221..385
FT /note="Protein export membrane protein SecD/SecF C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF02355"
SQ SEQUENCE 400 AA; 42628 MW; 059259A6AB991D3C CRC64;
MRRGVSGFIR EPRTITLIIL VVISLAAIST LGIPQGLDLK GGSIIQIQLE KPVDSATMNT
ITSVLDKRLN IFGVKDVKVR ASGNQNIIIE IAGVKPEEVA KIVGSPGKFE AKIDNKTVLT
GADIVSVQSP IIRGNQWEVP FRISTDSAKR FAEAAEGKAG APVDMYLDDR LITSPEISPD
VAAGKPVTDV AITGAESTRE SAELKAKEVE TLLKSGSLPV KVKIVGVSSV SAELGGEFAK
GALIAGLLAI IAIIIILVAR YRTPILVLPI FFTTLAELIL ILGVAAIIRW NIDLAAIAGI
LAAIGTGVDD QIIITDEVLG EEKVKRRRRR FRIREAFFII FASAGTLIAA MLPLAYVGFA
RGATGIGMLA GFAFTTVLGV LIGVFITRPV YAKFMEYIIK
//
