ID A0A328RXB5_9EURY Unreviewed; 2945 AA.
AC A0A328RXB5;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=Peptidase C1A papain C-terminal domain-containing protein {ECO:0000259|SMART:SM00645};
GN ORFNames=BZ136_09000 {ECO:0000313|EMBL:RAP44264.1};
OS Methanosphaera sp. rholeuAM74.
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanosphaera.
OX NCBI_TaxID=1945579 {ECO:0000313|EMBL:RAP44264.1, ECO:0000313|Proteomes:UP000248971};
RN [1] {ECO:0000313|EMBL:RAP44264.1, ECO:0000313|Proteomes:UP000248971}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RholeuAM74 {ECO:0000313|EMBL:RAP44264.1};
RA Hoedt E.C., Parks D.H., Rosewarne C.P., Denman S.E., Mcsweeney C.S.,
RA O Cuiv P., Hugenholtz P., Tyson G.W., Morrison M.;
RT "Culture- and metagenomics-based expansion of the genus Methanosphaera
RT reveals their evolutionary depth and metabolic versatility.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RAP44264.1}.
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DR EMBL; MUZZ01000280; RAP44264.1; -; Genomic_DNA.
DR Proteomes; UP000248971; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02619; Peptidase_C1; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR PANTHER; PTHR12411:SF741; CATHEPSIN K; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF13290; CHB_HEX_C_1; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00710; PbH1; 9.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF51126; Pectin lyase-like; 5.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000248971}.
FT DOMAIN 1134..1337
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 2945 AA; 331484 MW; A8D8565420DB0076 CRC64;
MSFEDTFYLY TGIIQYLYLN DELPDYYLVE DYRQIKHINV NNYAQLRTAI SNLNSQHIAA
IINLNGDNVY NIDTPIRFEN QLIYNITING NERILDGDNQ YSLMVIYGND YNVTLNNLTI
RNNYNYGYGS INNRGILQIY NSIFENNIGY FYSGIIMNHG TLFIKNTEIK NNYGHLISNI
ANFGNTTLIR NSIHHNHGNM GGLIWSNGTL TLEENSIKFN NANNGGAIFN NNSLSINGDS
IYNNTAIHGG AIDSTGNLTI LDANLTSNHA SSSGGALYLS NPTYIKNTFI HDNWAPQGGA
IFNTNNLTLI KNSIRNNMAT VSTPDTITIG GAVYSTGNTT LTENSVKFNS AVVGAVIYTT
DSTLSLNGDT IYNNTANTGA AINNQNSTIT SNATIFHDNK ARYGGVINNN GSYTSSHDYY
YNNTAVVLGG VILNMDNTLI ENSNFTQNTA KTRVNLTIDD NLTQVDGAYG GVIYNEGYIQ
IQASNFESNQ AQTEIISNPH NTYLNIGHGG VIYNDGICQL NNNAFNNNTA EKTAGVISNK
NTITATHNNF TNNKATITGG AIVNDYNANL TNNIFDNNTA NNMAGAVYNM ANITLNNNNF
TSNLAGSGSA ITTTNGKTNI SHNTFKNNYA PISGGAIQIN NEIDTIIEYN KFTNNNAEVG
ATIYADTSKI FSNNNNYTSN GYNNPIRIIT TIYGQYNTSN ITLIGGGIYL NKSILKNDDD
YFYNNKAEIH GAGIAAFNSL VSTNNTRFTN NNNTNGMGGA IYSDNSTIYI ESTKFTNNKA
LCGAAITHVG DTHLLVNNSN FTNNKASKTY AVLYSVKSTI NIENSTFNNN PSNNTPLIGI
YESKLTRIQS NLFKNSNPSI HINSSNLLLN NNLFTQGATH VLKTEAMGYY NIDNNYWGTN
TPNFSQKTYN ITPETIITQH NAHNYRMYLA MPTHTKNNST TQINLIITNS SHKIITPNGT
VSIQINNNES ITLNQQNNTF TYTYSIPAQY INVDTITITY NDDLTSTIIT ANKQLNITDN
AYFIVESPET AYPNEQILLK TKLINSFNNL RSDGQITAKF DNTNMGTFTK VGEKYQLTYS
IPSTALGIHT IQVIFTDSEN NIITQNHTIN ILNNKTIINV PGNNVIDDDE TITITSSYDL
RDYTWTTPVQ SQGDSGSCWA FATTASLESS ILKTQDNTYN FSENNLKNMV SSNSQLNTDL
TVNTGSDLLQ AASYYNSWTG PVTEDKDKYY AYSSLSLLQE KDYKVQNIVF IPNRQNTMDN
TQIKSAIMKY GAVTTTTYLN DDNNNGYNDE LHTPNHAVSI IGWDDNYDKN NFANTPPGDG
AFLVEDSTTN TQYYYISYYD VNFAGLYSAT ANNGLYVNNI AFDTREDNRY DNIYQQSVLA
YDGYATLDSQ DLWINNTYTI TANQTITAIG TYFLNQSQYQ ADIYKNNHKV YTQTGNINTL
GYRTIPLNYH IQCNKNDEIN IIVKITSNTQ NTTGYILERT LSTYSQEGLS QISQNGINWT
DLYYYPQFYD RYSHSASLKL YTNNTTTQEY RLNITSEIYQ NNPLKIRITD DNGLNLINKE
LNITLDGITQ TFTTDTQSTI SINTANLEIG SHCIVINSFN EFNIDTTITV LNDTTTSLES
DEINIDVLTD TLYLSDTNNI LTHTYYDDYV NVNVGKIVLK LNGKTLKDAQ NNKLYANVVN
GTTNSQYYIN GVTQGNHTLK IIYSHGSTQK TLNKTIRVLK QDVILGVNPV EAFIGDTLSV
TANVTYSNGT TITNKPLSFK VNGVTLATQT ITDGQATLNT NVPGTWKKGE YELELVVGET
STSNSIRYKT ILTIYDSRNT GNVNDYSTYY PVYGETQHTN GLITINPTEV DISTSIKKVK
INITTVDNLT MYYTTDGTMP TYNSGSLTEN AEIYIRLQST SGKTVNHDLH STAQTFKPYI
FKYFYVYNGL ESEVFYHQIT TTLHTMDNEY PSYYAQVNIM PDTDYRTPDI GYNIIETSTV
QKIVLTANKL GTINYHINNN NTQTYTPHTL LTVHNGDILH TTFTDTLTTT VSEEISIDYP
SYTPLVVVKP LSDLVDGQQN ITFTSDDEDI TIYYTRDGSD PHNTTNLRTA DLTTKLTLNN
LTQLKYYAED ANTHIQSEVT LYRTPKNEVI QPTITIKSED SIDNTERLII QTDKIYNIHI
TTDGTVPDEN NIEYDYHEIR MHNSNTLNIA LVDQNKHYYY YQYHNGELTR YTPINYTIIL
PNYHNITLPN VNKYNDPMDD YILEEGENGT IMLPFIRLTS ININNNIYYF TDFPLNGVND
LNNNIYHISS DGTIKTTTTL NKPQTTGITI YKQDNTTVIT YNDKVYNSIN QFNVEYTTRP
DISGEEIKLI DSINFNIDDY STAIIETNTV PYEELSYTTT SDIGIRNQLA KQNNYNGNIL
TSTYAQICNN NIPTITYTKN HNNIHYNTNG EPDYNYFINN PNIYKTIVTI NNKQNTRTFT
LSHQDQETIL KNNTLTQTQK IQQLQNMTLK YTGTLESYAI VNKKITQTDI NILLNNVGGY
NLSARDAYFL SALKIVEMYD SHAEYKAYTY NLSWNRTSTI TTSIYVNASH IITHTFTPDM
GMEVQETIFS TAFTFETTIS LNYYESKMLN IIRNRTGNRT IPSNIETILS KLNTNSIQVY
TNNNHIIIMD PENNITLIID TLTGIVTDIT ISEDGNYHGI ETICLNCEFN PSDNSSTIIN
ILSSFDVYYD DSFNLTVGGY IINALVQSYI NRPPFLDCVF SGMKISKTEI YLFIMDTILH
TWIIHNNMVV SDEFNNDEMF FLKNQKEYYL LDAFYESSYI FLNTIYSHLN LGGKLFGTDD
VHDIHVNYGP KLKTTPVMPS LYDGYYTITL PKQPAGEVNS TNVFYNNYPP YVTIKINTNV
VGFGQYDYTR AYYIDPVKGE KRNLSESEAK QYFKNSFIED NNPFQHFLQS PLDGVDLHEF
YEEYP
//
