ID A0A329N038_9FLAO Unreviewed; 928 AA.
AC A0A329N038;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Insulinase family protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DN748_11195 {ECO:0000313|EMBL:RAV28949.1};
OS Sinomicrobium sp. N-1-3-6.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Sinomicrobium.
OX NCBI_TaxID=2219864 {ECO:0000313|EMBL:RAV28949.1, ECO:0000313|Proteomes:UP000250485};
RN [1] {ECO:0000313|EMBL:RAV28949.1, ECO:0000313|Proteomes:UP000250485}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N-1-3-6 {ECO:0000313|EMBL:RAV28949.1,
RC ECO:0000313|Proteomes:UP000250485};
RA Liu X., Lai Q., Shao Z.;
RT "Sinomicrobium soli sp. nov., isolated from arctic soil.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RAV28949.1}.
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DR EMBL; QLNV01000007; RAV28949.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A329N038; -.
DR OrthoDB; 9811314at2; -.
DR Proteomes; UP000250485; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR PANTHER; PTHR43690:SF34; ZINC PROTEASE PQQL-LIKE; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000250485};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 47..166
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 205..383
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 682..859
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 928 AA; 105270 MW; 891A407385D80E59 CRC64;
MKIITTVSLF LWSGILLNAQ DKGEVPFDPS VRHGVLPNGM TYYIKHNEEP KERASFYFAQ
NVGSILEKES QRGLAHFLEH MAFNGTEHYP EKSMLQYLEK NGIKFGAEIN AFTSFDETVY
NISKVPVTNR KLLDSTLLVL HDWSGYLSLT DEEIDAERGV INEEWRTRNT PSFRVAEKVW
TRGILKGSLY GERMPIGLMS VVNNFEYDEL RDYYRQWYRP DQQAVIVVGD VDVDDMEAKI
KDVFSPVPLK KGLPERKPFS AKMNGDITFI ESLDKEVGST RIEFSVKNEA RRLKGYDYLD
DNLVKGIASY VLNNRFKEQT VKKTCPALSA GYSYSNFVRP LDVMGLAVQP KTDKELESFE
FALTELLRFV RYGATDSELE RAKLSIKNSN LSYLKNKDKI SSDSYAESIY QHFFTGDPLP
DVTWNVNYRV DRLETITNED ILNYMAGVYK KEDIVIAVKG TSDKTYPEKE QFVDIFNKVN
AMKLEPYEDT VDDKPLIAET LEEQPVTGKT DIPGMDARKY ELGNGARVVV FPTPYDKDKI
YLSAYSPGGN SLLGKDLLPS ANVATYVASQ SGLGDFDEIE LGKKLAGTNT SLGLDINELS
ESMSGQSTRS DLEVLFQKIY LSFEAPRFDR EAYDLARERF SKSLEQKQKN KKSILQDSMS
MALTSHNERT LLFTPEFIDE IDLGKIEKVY KERFQGIDDF TFVFIGDIDE AQLVELARKY
IGNISAGKGK EDYVDHNYNP AKGKTVVRVT EEMETPQATV NVVYKGEMPY SYSNSIKVYM
AGQLLQKSCH DVIREEEGGS YGVGASASLG DRPREAFSMS VGFDCNPEMA DKLVQVVYNE
IEKLTGTIDA EDFREVKESM IKSRKEAVNN NNYWMSVLSS HVFYGKEIHT LDDYINTVNA
ITAEDIKETV RNMEKKADIV EGVLLPKS
//
