ID A0A329N597_9FLAO Unreviewed; 603 AA.
AC A0A329N597;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203};
GN ORFNames=DN748_08470 {ECO:0000313|EMBL:RAV29518.1};
OS Sinomicrobium sp. N-1-3-6.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Sinomicrobium.
OX NCBI_TaxID=2219864 {ECO:0000313|EMBL:RAV29518.1, ECO:0000313|Proteomes:UP000250485};
RN [1] {ECO:0000313|EMBL:RAV29518.1, ECO:0000313|Proteomes:UP000250485}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N-1-3-6 {ECO:0000313|EMBL:RAV29518.1,
RC ECO:0000313|Proteomes:UP000250485};
RA Liu X., Lai Q., Shao Z.;
RT "Sinomicrobium soli sp. nov., isolated from arctic soil.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RAV29518.1}.
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DR EMBL; QLNV01000005; RAV29518.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A329N597; -.
DR OrthoDB; 9804933at2; -.
DR Proteomes; UP000250485; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SMART; SM00278; HhH1; 1.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00203}; Reference proteome {ECO:0000313|Proteomes:UP000250485};
KW SOS response {ECO:0000256|HAMAP-Rule:MF_00203}.
FT DOMAIN 15..93
FT /note="GIY-YIG"
FT /evidence="ECO:0000259|PROSITE:PS50164"
FT DOMAIN 262..476
FT /note="UvrC family homology region profile"
FT /evidence="ECO:0000259|PROSITE:PS50165"
SQ SEQUENCE 603 AA; 69859 MW; 47CF95F8104C772F CRC64;
MSTTSVEILL QTLPDSPGVY QFYDKDGRIL YVGKAKNLKK RVSSYFHKHH DYGKTRVLVK
KIADIRHIVV PTETDALLLE NNLIKKYQPR YNVLLKDDKS YPWICIKKER FPRIFSTRRV
VRDGSEYFGP YTNMKTIRTL LELIKGLYPL RTCNYDLSKA KVDSGKYKVC LEYHLGNCKG
PCEDYQSEEE YNAQVRAIRE IIKGNFKDSL QGFRKQMKVY AAEMRFEDAQ KMKERIEVLE
NYQAKSTIVN PRISNVDVFS IVSDDSYGYV NFLQLSYGAI IRAHTVEMKK KLDESDRELL
ELAITEIRQR FHSLSREVYV PFDVEVPEGI KVTIPKLGDK KRLLELSERN AKFYRQERFK
QVKITDPDRH VKRIMEQMKK DLRLKEEPRH IECFDNSNIQ GTHPVAACVV FKDGKPSKKD
YRHFNIRTVE GPDDFASMEE VVFRRYKRLL TEGEPLPQLI VIDGGKGQLS SALKSLEVLG
LRGKIAIIGI AKRLEEIYYP GDSVPMYLDK KSETLKIIQH LRNEAHRFGI TFHRNKRSNA
AIDSELTNIE GIGEKTAEEL LKAFRSVRRV KEAGIEEISG VVGLSKARRI HDYFHPGTGE
KGK
//
