ID A0A329SC39_9STRA Unreviewed; 508 AA.
AC A0A329SC39;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Presenilin {ECO:0000256|RuleBase:RU361148};
DE EC=3.4.23.- {ECO:0000256|RuleBase:RU361148};
GN ORFNames=JG687_00009763 {ECO:0000313|EMBL:KAG6957778.1}, PC110_g10449
GN {ECO:0000313|EMBL:RAW33208.1}, PC113_g10846
GN {ECO:0000313|EMBL:KAG2857266.1}, PC115_g9516
GN {ECO:0000313|EMBL:KAG2921495.1}, PC117_g11341
GN {ECO:0000313|EMBL:KAG2938164.1}, PC118_g10382
GN {ECO:0000313|EMBL:KAG2981802.1}, PC129_g10296
GN {ECO:0000313|EMBL:KAG3218908.1};
OS Phytophthora cactorum.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=29920 {ECO:0000313|EMBL:RAW33208.1, ECO:0000313|Proteomes:UP000251314};
RN [1] {ECO:0000313|EMBL:RAW33208.1, ECO:0000313|Proteomes:UP000251314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10300 {ECO:0000313|EMBL:RAW33208.1,
RC ECO:0000313|Proteomes:UP000251314};
RA Armitage A.D., Lysoe E., Nellist C.F., Harrison R.J., Brurberg M.B.;
RT "Draft genome of the strawberry crown rot pathogen Phytophthora cactorum.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAG3218908.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=15-7 {ECO:0000313|EMBL:KAG2857266.1}, 4032
RC {ECO:0000313|EMBL:KAG2921495.1}, 4040 {ECO:0000313|EMBL:KAG2938164.1},
RC P415 {ECO:0000313|EMBL:KAG2981802.1}, and P421
RC {ECO:0000313|EMBL:KAG3218908.1};
RA Armitage A.D., Nellist C.F., Bates H., Vickerstaff R.J., Harrison R.J.;
RT "Effector identification in a new, highly contiguous assembly of the
RT strawberry crown rot pathogen Phytophthora cactorum.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAG6957778.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NZFS 3830 {ECO:0000313|EMBL:KAG6957778.1};
RA Mcdougal R., Panda P., Williams N., Studholme D.J.;
RT "Phytophthora aleatoria, a newly-described species from Pinus radiata is
RT distinct from Phytophthora cactorum isolates based on comparative
RT genomics.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable subunit of the gamma-secretase complex, an
CC endoprotease complex that catalyzes the intramembrane cleavage of
CC integral membrane proteins such as Notch receptors.
CC {ECO:0000256|RuleBase:RU361148}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU361148}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU361148}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU361148}. Golgi apparatus membrane
CC {ECO:0000256|RuleBase:RU361148}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU361148}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The PAL motif is required for normal active site conformation.
CC {ECO:0000256|RuleBase:RU361148}.
CC -!- SIMILARITY: Belongs to the peptidase A22A family.
CC {ECO:0000256|ARBA:ARBA00008604, ECO:0000256|RuleBase:RU361148}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RAW33208.1}.
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DR EMBL; RCMG01000297; KAG2857266.1; -; Genomic_DNA.
DR EMBL; RCMI01000263; KAG2921495.1; -; Genomic_DNA.
DR EMBL; RCMK01000291; KAG2938164.1; -; Genomic_DNA.
DR EMBL; RCML01000297; KAG2981802.1; -; Genomic_DNA.
DR EMBL; RCMV01000336; KAG3218908.1; -; Genomic_DNA.
DR EMBL; JAENGZ010000523; KAG6957778.1; -; Genomic_DNA.
DR EMBL; MJFZ01000245; RAW33208.1; -; Genomic_DNA.
DR STRING; 29920.A0A329SC39; -.
DR Proteomes; UP000251314; Unassembled WGS sequence.
DR Proteomes; UP000688947; Unassembled WGS sequence.
DR Proteomes; UP000697107; Unassembled WGS sequence.
DR Proteomes; UP000735874; Unassembled WGS sequence.
DR Proteomes; UP000736787; Unassembled WGS sequence.
DR Proteomes; UP000760860; Unassembled WGS sequence.
DR Proteomes; UP000774804; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR Gene3D; 1.10.472.100; Presenilin; 1.
DR InterPro; IPR001108; Peptidase_A22A.
DR InterPro; IPR006639; Preselin/SPP.
DR InterPro; IPR042524; Presenilin_C.
DR PANTHER; PTHR10202; PRESENILIN; 1.
DR PANTHER; PTHR10202:SF13; PRESENILIN-2; 1.
DR Pfam; PF01080; Presenilin; 1.
DR PRINTS; PR01072; PRESENILIN.
DR SMART; SM00730; PSN; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU361148};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU361148}; Hydrolase {ECO:0000256|RuleBase:RU361148};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361148};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976,
KW ECO:0000256|RuleBase:RU361148}; Protease {ECO:0000256|RuleBase:RU361148};
KW Reference proteome {ECO:0000313|Proteomes:UP000251314};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361148};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361148}.
FT TRANSMEM 68..89
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361148"
FT TRANSMEM 121..143
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361148"
FT TRANSMEM 150..174
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361148"
FT TRANSMEM 186..205
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361148"
FT TRANSMEM 212..229
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361148"
FT TRANSMEM 235..253
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361148"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361148"
FT TRANSMEM 479..497
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361148"
SQ SEQUENCE 508 AA; 57120 MW; A1A7CD1D7337EA14 CRC64;
MGNARSDTRS LASVHYLSVS GDESNSTMYE EPLLDKTRVY DAPRKEWQLQ QESEKVDLGA
VIHQLNSFFA VIWPVSNAII CSSLAASYIS DPVMTQAMKT YMYYQDIDSS ELSTAEKTEE
ALLNALLVIV FIAFLTFGIV LLYKCNGMHL FAWYCMLYSA ALLGLMGSKL VVIVLCGNLH
WVVDRISLTI VMYNFAMVGV LSIFYQKGIP GILERGYLIA TSVIVAWQLA QLPEWSVWML
LLLLGFWDLF AVLTPVGPLR CLVDLVQEKG TPIPGLLFEA DVEKAHVGGN TNTQNAQRRR
FATRDTIPEE VFMQRLLLAG QSENELQDHG PVNAALFRRQ VQVFLYDQNS QCQNHSEELA
QKFERNQLRL WRNLYTYYCV DYVSKQQLYP GIQAVFATSM DTYPAYASGG PNYSHEDSED
KSIKLGLGDF IFYSVLVARA SLHGFDVFAA CFLSILVGLG ITLYLLARFD ALPALPISLF
LGIITYLFMI TIISPLLNEL QAGNIFFI
//
