ID A0A329SI58_9STRA Unreviewed; 792 AA.
AC A0A329SI58;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Twinkle protein {ECO:0000313|EMBL:RAW36474.1};
GN ORFNames=PC110_g7246 {ECO:0000313|EMBL:RAW36474.1}, PC117_g4982
GN {ECO:0000313|EMBL:KAG2949780.1};
OS Phytophthora cactorum.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=29920 {ECO:0000313|EMBL:RAW36474.1, ECO:0000313|Proteomes:UP000251314};
RN [1] {ECO:0000313|EMBL:RAW36474.1, ECO:0000313|Proteomes:UP000251314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10300 {ECO:0000313|EMBL:RAW36474.1,
RC ECO:0000313|Proteomes:UP000251314};
RA Armitage A.D., Lysoe E., Nellist C.F., Harrison R.J., Brurberg M.B.;
RT "Draft genome of the strawberry crown rot pathogen Phytophthora cactorum.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAG2949780.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=4040 {ECO:0000313|EMBL:KAG2949780.1};
RA Armitage A.D., Nellist C.F., Bates H., Vickerstaff R.J., Harrison R.J.;
RT "Effector identification in a new, highly contiguous assembly of the
RT strawberry crown rot pathogen Phytophthora cactorum.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RAW36474.1}.
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DR EMBL; RCMK01000084; KAG2949780.1; -; Genomic_DNA.
DR EMBL; MJFZ01000138; RAW36474.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A329SI58; -.
DR STRING; 29920.A0A329SI58; -.
DR Proteomes; UP000251314; Unassembled WGS sequence.
DR Proteomes; UP000736787; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-KW.
DR CDD; cd01029; TOPRIM_primases; 1.
DR CDD; cd01122; Twinkle_C; 1.
DR Gene3D; 3.40.1360.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.90.580.10; Zinc finger, CHC2-type domain; 1.
DR InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR InterPro; IPR036977; DNA_primase_Znf_CHC2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR034154; TOPRIM_DnaG/twinkle.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR027032; Twinkle-like.
DR PANTHER; PTHR12873; T7-LIKE MITOCHONDRIAL DNA HELICASE; 1.
DR PANTHER; PTHR12873:SF0; TWINKLE MTDNA HELICASE; 1.
DR Pfam; PF13481; AAA_25; 1.
DR Pfam; PF13155; Toprim_2; 1.
DR SUPFAM; SSF56731; DNA primase core; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR PROSITE; PS51199; SF4_HELICASE; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Primosome {ECO:0000256|ARBA:ARBA00022515};
KW Reference proteome {ECO:0000313|Proteomes:UP000251314};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 283..365
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT DOMAIN 414..660
FT /note="SF4 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51199"
FT REGION 679..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..700
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..775
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 792 AA; 87507 MW; 5F13996B8545DDCF CRC64;
MRVFSRLVAT GRAVRRSNVP LMVSSSSSSR RCLATEAFVS RHYQMQDPKD VAEFLQRKSL
SVRETDSHFV VRDCPFCHAT HGKTDNLFKM YVHKTQGVYK CHRCGAAGSW FDFKRKLQGS
VGVASSSSAL YGGSNAGAPR ASAEVKVIQA LDNEKAMAIQ KNLLDDPEFQ PVLKYLTDIR
GLSKEVLQKY CVGAIEQPFW DHDAGERVNA QCISFPWMAR QMDMDAMGVV CQDEKRQTTE
DKNLYDVVRL KLRAMDDKAK QQLVPKGGSW GLFGWNTVPT TAQDLVLTEG EFDAIAVHQA
TGMAAVSLPN GCQSLPPSVL PLLERFKRIY LWMDNDASGQ SNVEKFAAKL GMARCYIVRL
PANAASSSIK DANDALRAGL DLTAIVNGAE RIPHSQITTF EELRRDVYEE IVNPLKACGV
QSRAFPSLNR LMKGHRMGEV TVLTGPTGCG KTTLLSQLSL DLCGQGVSTL WGSFEIKNTR
LLHKMLTQLA QRNLSGDVKA FEAAADRFEA LPMHFLRFFG STNVDEVLDA MEYAVYAYDV
QHILLDNVQF MMAGQGRGFD KFERQDAALD KFRKFASSKN VHLTLVIHPR KEQEDQDLTL
SSVFGTAKAT QEADNVLILQ RTRGESKLDI RKNRFDGTLG SIPLKFEPDS ASLREVGTES
MSEGVAAVDI EAEMELAQRR RMQKNSRTQE HLHPEPLDVD PQEDSSSQAF QYVAAAASDS
LNGHEHNGSY SFKVNGSCLP RLNGEDDHDL NGGSSGLNGN SRSNSPGSNL NGNGPRPSRG
EPFAAFTPII TR
//
