ID A0A329ZFT6_9HELI Unreviewed; 232 AA.
AC A0A329ZFT6;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=Cytolethal distending toxin subunit A {ECO:0000256|ARBA:ARBA00016112};
GN ORFNames=CCY97_07115 {ECO:0000313|EMBL:RAX53232.1};
OS Helicobacter sp. 10-6591.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=2004998 {ECO:0000313|EMBL:RAX53232.1, ECO:0000313|Proteomes:UP000251062};
RN [1] {ECO:0000313|EMBL:RAX53232.1, ECO:0000313|Proteomes:UP000251062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10-6591 {ECO:0000313|EMBL:RAX53232.1,
RC ECO:0000313|Proteomes:UP000251062};
RX PubMed=29225701; DOI=10.1186/s13099-017-0220-y;
RA Feng Y., Mannion A., Madden C.M., Swennes A.G., Townes C., Byrd C.,
RA Marini R.P., Fox J.G.;
RT "Cytotoxic Escherichia coli strains encoding colibactin and cytotoxic
RT necrotizing factor (CNF) colonize laboratory macaques.";
RL Gut Pathog. 9:71-71(2017).
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|ARBA:ARBA00004459}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004459}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RAX53232.1}.
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DR EMBL; NHYK01000022; RAX53232.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A329ZFT6; -.
DR OrthoDB; 5353389at2; -.
DR Proteomes; UP000251062; Unassembled WGS sequence.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR015957; CDtoxinA.
DR InterPro; IPR003558; CDtoxinA/C.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR Pfam; PF03498; CDtoxinA; 1.
DR PRINTS; PR01387; CDTOXINA.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 4: Predicted;
KW Cell outer membrane {ECO:0000256|ARBA:ARBA00023237};
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000251062};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Toxin {ECO:0000256|ARBA:ARBA00022656};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..232
FT /note="Cytolethal distending toxin subunit A"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016280347"
SQ SEQUENCE 232 AA; 25453 MW; 6631867E006BE613 CRC64;
MIRNILLVAF LVFFSSCSSK KDVLGIGKSP NPPTKSKGLK LVSGPNLSAK LQHLNTDNKA
SDTSTPNLLL FANDAASKSS TSDPLSIMSP EGGVLTLWAL NPGNWVWGYS LNDSIDFGSA
RIWRIHTDSN GNSIIENVKK KTCLTAYANG VVHTYCDSKN TKQLWKFNLF DNQAVQIQNV
GTQQCLQTPS KASDPYFFIY LTDCVKSGKK NSDQQWIIIA EPLDADIVFS VN
//
