ID A0A330L2T4_9BACT Unreviewed; 724 AA.
AC A0A330L2T4;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Squalene--hopene cyclase {ECO:0000313|EMBL:SPP63513.1};
DE EC=4.2.1.129 {ECO:0000313|EMBL:SPP63513.1};
DE EC=5.4.99.17 {ECO:0000313|EMBL:SPP63513.1};
GN Name=shc {ECO:0000313|EMBL:SPP63513.1};
GN ORFNames=NITLEN_10599 {ECO:0000313|EMBL:SPP63513.1};
OS Nitrospira lenta.
OC Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC Nitrospira.
OX NCBI_TaxID=1436998 {ECO:0000313|EMBL:SPP63513.1, ECO:0000313|Proteomes:UP000248168};
RN [1] {ECO:0000313|Proteomes:UP000248168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucker S., Sakoula D.;
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004999}.
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755}.
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DR EMBL; OUNR01000001; SPP63513.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A330L2T4; -.
DR InParanoid; A0A330L2T4; -.
DR OrthoDB; 9758578at2; -.
DR UniPathway; UPA00337; -.
DR Proteomes; UP000248168; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0051007; F:squalene-hopene cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR006400; Hopene-cyclase.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01507; hopene_cyclase; 1.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:SPP63513.1};
KW Lyase {ECO:0000313|EMBL:SPP63513.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248168};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 69..361
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 381..698
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 724 AA; 81764 MW; 061B8187104E7F67 CRC64;
MKLFRTLFDR ISSSLLATIP GKYNPAIGYA QAPPLRLVSD KITPLAAPDL SRRPSAHTVS
QPDAIDDAIR RSQSWFLSKQ DPAEGFWVAE LEADTTLTSE YLMLRRFLDC VDPVKEERAV
KYLRTMQLPD GGWPIHYGGP AEISASVKAY FALKLSGVPA TDPCLLRAHE RIMVMGGVVQ
ANVFTKIALA LFDQYDWEGV PHMPVEIMLL PKRFYFSIYA ISYWSRAVLI PLLIVFAHQP
VCRIPREQGI EELYLVPRGQ VPYWKYPPFN KDQAWFTPHN FFVMLDAVLK LYDRMPLLWL
REKAMHKAAT WMLDHLKGSG GLGAIYPAMA NSVLALRCLG YEMDDPLVQK ALREIEELEV
YDTATLDGQR VATLHLQPCH SPIWDTALLM NALSEAGMPQ DHPALVKAGA YLMSRQTKAV
GDWTISSPQA EPGGWYFQFE NELYPDVDDS AVVLMALAKL KMPEPADLRE SIRRGMQWVL
AMQSSDGGWG AYDKDNNRVV FNYIPFADHK ALLDPSTADL TGRCLEMLGA LGYDRSHPAA
QSALAFIKKE QEADGSWYGR WGVNYIYGTW SVLAGLRAIG EDVSSPYIRR AVSWLESKQN
PDGGWGEACH SYAEEAHSGK GQSTPSQTAW ALMALMSAGV TESLSIARGV QFLLRHQLKD
GSWEEVMHTG TGFPRVFYLR YHWYCQYFPL WALAMYRNLR SRGRMRSEEL QEQVESSGCY
RFDH
//
