ID A0A337RTY8_FELCA Unreviewed; 982 AA.
AC A0A337RTY8;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Rho guanine nucleotide exchange factor 1 {ECO:0000313|Ensembl:ENSFCAP00000040334.2};
GN Name=ARHGEF1 {ECO:0000313|VGNC:VGNC:107050};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000040334.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000040334.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000040334.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000040334.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000040334.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000040334.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000040334.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AANG04000747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A337RTY8; -.
DR Ensembl; ENSFCAT00000062432.2; ENSFCAP00000040334.2; ENSFCAG00000008128.6.
DR VGNC; VGNC:107050; ARHGEF1.
DR GeneTree; ENSGT00940000161180; -.
DR Proteomes; UP000011712; Chromosome E2.
DR Bgee; ENSFCAG00000008128; Expressed in spleen and 10 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd14679; PH_p115RhoGEF; 1.
DR CDD; cd08755; RGS_p115RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR037887; p115RhoGEF_RGS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015212; RGS-like_dom.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR45872:SF4; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF09128; RGS-like; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 417..606
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 648..761
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 234..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..359
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..794
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 982 AA; 109600 MW; 51C8E13CCAD0BF70 CRC64;
MEADDIARGL APGPPRPGLV PVSIIGAEDE DFENELETNA EEQNSQFQSL EQVKRRPAHL
MAFLQHVALQ FEPGPLLCCL HADMLGSLGP KEARKAFLDF CHSFLEKTAV LRVPVPPTVA
FELDRTRPDL LSEDLQRQFV QEVVQSQQAT VSQLLEDFRS KRLMGMTPWE HDLTQLEAWV
GRDRASFEAR ERHLAERLLT HLEEMQHTIS TDEEKSAAVV NAISLYMRHL GVRTKSGDKK
SGRNFFRKKM IGNRRSDEPT KTKKGLSIFL DAARWNRGEP QAPDFRHLKV EADAEKPGLT
ERKGGLGVPS RDRNTGAAGQ DIAGVSLHPL SGDSPDREPG VDAPPELGDP PPQGPASLEP
VVPPENTEEG AETESPEPGD EGDPGRSGLE LEPEEPPGWR ELVPPGTLHS LPKSQVKRQE
VISELLVTEA AHVRMLRVLH DLFYQPMAEG GFFPLEELQY IFPSLDELIE VHSQFLDQLM
KRRQDSGYLI EEIGDVLLAR FDGAEGSWFQ KISSRFCSHQ SFALEQLKAK QRKEPRFCAF
VQEAESRPRC RRLQLKDMIP TEMQRLTKYP LLLQSIGQNT EELAEREKVE RAAECCREIL
HHVNQAVRDM EDLLRLKDYQ KRLDLSHLRQ SSDPMLNEFK NLDITRRKLV HEGPLTWRVT
KDKAVEVHVL LLDDLLLLLQ RQDERLLLKS HSRTLTPTPD GKTMLRPVLR LTSAMTREVA
TDHKAFYVIF TWDQEAQIYE LVAQTVSERK NWCALITETA GSLKVPAPAS RPKPRPSPSS
TREPLLSSSD NGNCGGREMP PADGRMERIF STLLPYCRPG PEGQLAAKAL EKGGGRGILS
CTTPPVSAWG KPCPPAWLYL RLPAPGSPQA FRKTEGHPPP PHSCRSISNP KGLRRGSQAC
LGGPAGITAS PQPPIGLGLL SLLPSAWGTQ GFIPGRTHSD LPFPGPALYC LGLGHPSIPP
PPSAFALFLY PELEVYFLIY IT
//
